Hotline:400-820-3792Inhibitors?Agonists?ScreeningLibrarieswww.MedChemEClobetasonebutyrateCat.No.:HY-B1616CASNo.:25122-57-0分?式:C??H??ClFO?分?量:478.98作?靶點:GlucocorticoidReceptor作?通路:GPCR/GProtein儲存?式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性數據體外實驗DMSO:≥250mg/mL(521.94mM)*"≥"meanssoluble,butsaturationunknown.MassSolvent1mg5mg10mgConcentration制備儲備液1mM2.0878mL10.4388mL20.8777mL5mM0.4176mL2.0878mL4.1755mL10mM0.2088mL1.0439mL2.0878mL請根據產品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存?式和期限。體內實驗請根據您的實驗動物和給藥?式選擇適當的溶解?案，配制前請先配制澄的儲備液，再依次添加助溶劑(為保證實驗結果的可靠性，體內實驗的?作液，建議您現(xiàn)?現(xiàn)配，當天使?；澄的儲備液可以根據儲存條件，適當保存；以下溶劑前的百分?指該溶劑在您配制終溶液中的體積占?)：1.請依序添加每種溶劑：10%DMSO>>90%cornoilSolubility:≥6.25mg/mL(13.05mM);ClearsolutionBIOLOGICALACTIVITY1/2MasterofSmallMolecules—您?邊的抑制劑?師www.MedChemE?物活性Clobetasonebutyrate?種糖?質類醇(glucocorticoid)，具有局部抗炎活性，尤其在?膚上。Clobetasonebutyrate可?于緩解?質類醇反應性癥狀，包括特應性?炎和??癬。IC50&TargetIC50:glucocorticoid[1]體內研究Clobetasonebutyrate(applicationontheskin;0.05%;7weeks)inducesepidermalthinninginskin,Clobetasonebutyrate7weekscausesmuchlessepidermalthinninginthepigthanflurandrenolone(0.05%)orfluocinoloneacetonide(0.025%),bothofwhichcausessevereatrophy[1].AnimalModel:Largewhitedomesticpig[1]Dosage:0.5%applicationontheskinAdministration:7weeksResult:Causedmoderatetoslightatrophy.REFERENCES[1].MunroDD,etal.Clobetasonebutyrate,anewtopicalcorticosteroid:clinicalactivityandeffectsonpituitary-adrenalaxisfunctionandmodelofepidermalatrophy.[2].MichaelStewart,etal.Clobetasonebutyrateforinflammatoryskinconditions.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792