會(huì)計(jì)學(xué)1FabricationofMiniaturizedAcousticalLensesforHigh高的微型聲學(xué)透鏡制造MaterialsCharacterization-FacilitiesEquipment&TechniquesUHVSurfaceAnalysisSystem(XPS,UPS,Auger,…)surfacechemistryandelectronicbandstructure,in-situsurfacemodificationUltrafast(femto-sec)TransientAbsorptionSpectroscopyFieldEmissionGunTransmissionElectronMicroscope(FEGTEM)high-resolutionimaging,diffraction,andchemistryScanningElectronMicroscope(SEM)morphologyandelementalanalysisX-RayDiffraction(XRD)bulkphaseidentification,crystallography,phasetransformationsThermalAnalysis–DSC&TGAheatcapacity,meltingpoint,freezingpoint,etc.Photoluminescence/RamanSpectrometer(PL/Raman)emissionefficiency,band-gap,Ramanshifts(sensitivetobonding)FourierTransformIRSpectrometer(FTIR)localvibrationalmodes(sensitivetoimpuritiesandbonging)ParticleSizeDistribution(PSD)TeamJacekJasinski–ThemeLeaderRodicaMcCoy–LabManagerTimothyGutu–Post-doctoralScholarMeysamAtkhar–Grad.Student(Physics)RodicaJacekTimMeysam第1頁(yè)/共14頁(yè)THENANO-LABORATORY

ElectronMicroscopewithjoystickcontrolNanoneedlesshownontopmonitorsNanofiberair-bridgesspanmicropillarsonbottommonitorsTheHusonNanotechnologyCoreFacilitypursuescollaborativeresearchinelectrooptics&nanotechnology.Membersuseuniquetoolsforreal-timefab&characterizationofnanostructures.第2頁(yè)/共14頁(yè)TheJohnJ.HusonandMariaMeekHusonNanotechnologyCoreFacility(HNCF)Contacts:R.W.CohnorJ.P.Williams(SRB106)HNCFhousesacompletesuiteofnanotoolsforimaging,manipulation,probing,fabricationandmaterialsanalysisofnanostructureddevicesandmaterials.HNCFisashareduserfacilityopentostudentsandfacultyuponcompletionoftraining.Majorequipmentincludes:ScanningElectronMicroscopes(1nmresolution)+accessories:

EnergyDispersiveX-RaySpectroscopy—AtomiccompositionanalysesScanningTransmissionMicroscopy—ImagingthroughthinsamplesVariablePressure–ForstudyingwetsamplesandchangeswithhumidityNanomanipulators–Electrical/mechanicalprobing&fabofnanostructuredmatterAtomicForceMicroscopes(AFM)+options:

Atomicscaletopography,viscoelasticmappingofsoftmatter&polymers,conductivemapping,measurementsofadhesion,friction,wetting,anti-bodybindingandproteinunfoldingforces BIO-AFM:CombinedAFMandfluorescentimagingwithabiologicalmicroscope

AutomatedChemicalPress(5nmresolution)withcontrollableUV,thermalandpressureEllipsometer–Measurerefractiveindex&thicknessofsingle&multilayerfilms&coatingsNon-contactopticalprofilingmicroscope(1nmverticalresolution)ExtensionalRheometer–Measuresextensionalviscosityofpolymericliquids第3頁(yè)/共14頁(yè)LoDIExpertiseIntelligent-agentbased,real-timedecisionsupportsystemsforAS/RSandHealthcareLogisticsERprocessimprovementFacilityLocationforPediatricsPhysiciansSchedulingDeterministicandstochasticoptimizationfor:EmergencycallcenterplanningSkillsManagement/WorkforcePlanningSupplychainmanagement,logistics,layout,location,orderpicking,warehouselayoutDesignandAnalysisofAutomatedStorage&RetrievalSystemsApplicationofRFIDtoimproveintra-andinter-plantlogisticsIntegrationofdesignandplanninginadvancedlogisticalsystemsSimulationmodelsforwarehouseperformanceanalysisOptimalgoodsdistributionDesignofnextgenerationfactorylayouts第4頁(yè)/共14頁(yè)HospitalPatientAllocation第5頁(yè)/共14頁(yè)第6頁(yè)/共14頁(yè)MicroNanoTechnologyCleanroom(MNTC)

$30M,10,000sqftstate-of-the-artfacilityDr.KevinWalsh,FoundingDirectorClass100/1000,OpenedSummer2006Rankedtop10inUSAbySmallTimesMagazineMicro/nano/bioresearchthrustOver100usersfrom8Depts$5Mofresearchayear(1/3ofSpeedtotal)Produced5Startupsandover25PatentsUsedby5classestotrainU/GstudentsOutreach–500kidsayrtourcleanroomAdvancedModelingandPackagingLabsHomeforInterdisciplinaryResearchEngineeringPhysicsChemistryBiologyMedicine

SUMMARY第7頁(yè)/共14頁(yè)SamplePrototypeDevices(Wecanmakeanythingyoucanimagine)Micro-NeedlesMicroCagesforCellsLab-on-a-ChipSystemsImplantablePressureSensorsRFTemperatureSensorforAircraftTiresMicro-hotplateExplosivePreconcentratorWirelessGlaucomaSensorFlowSensorGasSensorThermalActuatorMEMSAccelerometer第8頁(yè)/共14頁(yè)WallaceH.CoulterTranslationalPartnershipAwardAwardedtotheUniversityofLouisvilleDepartmentofBioengineeringin2011$5Milliongrantprogram(over5years)Programgoals:AddresssignificantunmetclinicalneedorcostreductionProvides“gapfunding”fortranslationalresearchAwardsaretypically~$100,000PromotemedicalinnovationthroughEngineer-PhysicianPartnershipProvidearoadmapforcommercializationofUniversitytechnologyMilestonedrivenProprietarytechnology/Technologydevelopmentstage/businessplanFollow-onfundingpotentialExpectedoutcomes:Inventions,patents,improveddiagnosisandtreatmentofdisease,commercialproducts,licenses,partnershipsandstart-upcompanies第9頁(yè)/共14頁(yè)TimelinePre-proposalsdue:November16,2012Fullproposalinvitations:December14,2012Fullproposalsdue:February1,2013AnnouncementofProjectsInvitedforPresentation:TBD(April2013)PresentationstoOversightCommittee:TBD

(May/June2013)FundingStartDate:July1,2013第10頁(yè)/共14頁(yè)VentureCapitalandEntrepreneurMembersGeorgeEmont(Triathlon/KYSeedCapitalFund)StevenGailar(MetaCyte/KYSeedCapitalFund)CarterMcNabb(RiverCityCapital)PaulSpence,MD(SCR,Inc)SchoolofMedicineMembers/ClinicalHenryKaplan,MD(Ophthalmology)CraigMcClain,MD,PhD(GI)DonaldMiller,MD,PhD(Oncology)MarkSlaughter,MD(Cardiovascular)OTTHollySymondsClark,PhDMeleaEast,JDCoulterPrincipalInvestigatorRobertKeynton,PhDCoulterFoundationmemberMikeGara

TranslationalResearchPartnershipOversightCommittee第11頁(yè)/共14頁(yè)BioengineeringPrincipalInvestigatorRobertKeynton,PhDChair,ProfessorandLutzEndowedChairofBiomechanicalDevicesDepartmentofBioengineering,SpeedSchoolofEngineeringSchoolofMedicineMarkSlaughter,MDProfessorandChief DivisionofThoracicandCardiovascularSurgery

UniversityofLouisvilleSchoolofMedicine

CoulterTeamUofLOfficeofTechnol