第1題Whichofthefollowingiscorrectaboutthemorphologicalfeaturesofapoptosis?ACellshrinksBChromatincondensesCTheplasmamembraneisblebbingDAlloftheabove第2題Which

descriptionabouttheapoptosisisnotcorrectACaspase8isinvolvedinextrinsicpathwayofapoptosisBCaspse9isrelatedtoextrinsicpathwayofapoptosisCCytochromeCisinvolvedinintrinsicpathwayofapoptosisDCaspase3isapoptosis

effector第3題Whichofthefollowingiscorrectabouttheapoptosis?AApoptosisisessentialforthematureorgansBApoptosisisessentialfornormaldevelopmentCApoptosiscandestroycellsthatdoharmtohomeostasisDAlloftheabove第4題Whichofthefollowingiscorrectaboutpro-oncogene?AItisanormalcellulargeneBTheyarenormallyinvolvedinthecontrolofthecellcycleCWhenmutatedorinappropriatelyexpressed,cancauseacelltobecomemalignantDAlloftheabove第5題WhichofthefollowingiscorrectaboutBcl-2family?AItisahumanpro-oncogeneBBcl-2proteinisfoundintheendoplasmicreticulumCBcl-2proteinisalsodetectedinthemitochondriaDAlloftheabove第6題WhichofthefollowingiscorrectaboutIAPs?AIAPsmeaninhibitorsofapoptosisproteinsBTheycandirectlyinhibitcaspaseactivityCTheycandirectlyinteractwithcaspase3DAlloftheabove第7題Whichofthefollowingiscorrectaboutp53?ATargetgenesincludeBax/BakandBidunderDNAdamage.BCytoplasmicp53suppressesBcl-2/Bcl-xLresultinginthedissociationofBax/BakfromBcl-2/Bcl-xL.Cp53caninduceoligomerizationofBax/BakDAlloftheabove第8題WhichofthefollowingiswrongaboutNF-kB?ABcl-2candownregulatethetranscriptionfactorNF-kBBInhibitorsofNF-kBcanleadtoapoptosisviaderegulationofbalancebetweenantiapoptoticandproapoptoticfactors.CNF-kBcanserveasatargetofanti-tumordrug.DNF-kBcanbeupregulatedbyBcl-XL.第9題Whichofthefollowingiscorrectabout

apoptosis?AInnormalcells,phosphatidylcholineandsphingomyelinareonexternalleafandphosphatidylserineareintheinnerleaflet.BPhosphatidylserineistranslocatedtoexternalleafinanearlyapoptoticchange.CAnnexinVcanbindtoexposedPSinCa-dependentmanner.DAlloftheabove第10題Whichofthefollowingiscorrectaboutapoptosis?ACellshrinkageBMembraneintegritymaintainedinearlystepsCChromatincondensationandDNAladderingDAlloftheabove第1題Whichofthefollowingiscorrectaboutautophagy?AAutophagyisacellularprocessofself-eatingBIntracellularcomponentsaredegradedwithinthelysosomeduringautophagyCItisanevolutionarilyconservedresponsetodifferentstresses.DAlloftheabove第2題WhichofthefollowingiscorrectaboutAtg1/ULKcomplex?AAfterinductionofautophagy,theATG-ULKcomplextranslocatestotheendoplasmicreticulumBAtg1/ULKcomplexcantriggeractivationofPI3kinasecomplexCAtg1/ULKcomplexcaninduceformationofPI3PphospholipidDAlloftheabove第3題Themembranesourceofautophagosome

isviewedtobeAEndoplasmicreticulumBGolgicomplexCEndosomesDAlloftheabove第4題Whichofthefollowingiscorrectabout

Atg9?AInmammals,mAtg9traffickedbetweentheGolgiandendosomesinthepresenceofnutrientsBmAtg9isalsofoundinreservoir-likestructuresclosetoGolgiandendosomesCUponautophagyinduction,mAtg9distributestoendosomalcompartmentsDAlloftheabove第5題Whichofthefollowingiscorrectabout

PtdIns3Kcomplex?AActivationoftheATG1complexintheinitiationstageresultsinphosphorylationofATG6(Beclin1)ofthePtdIns3KcomplexBThesignallipidPtdIns3PisgeneratedbythePtdIns3KcomplexCItisrequiredforbindingofotherautophagyproteinstothemembranesuchasATG18andATG2DAlloftheabove第6題Whichofthefollowingiscorrectaboutubiquitin-likeconjugationsystems?ATheATG12~5/16complexregulatestheconjugationofATG8(LC3inmammals)tophosphatidylethanolamine(PE)attheisolationmembrane.BATG8bjoinsthegrowingautophagosomebeforeATG8a.CATG8bismainlylocalisedattheoutsideandATG8aattheinsideoftheautophagosomeDAlloftheabove第7題TheprocessoftheautophagyincludesACytoplasmicmaterialistargetedbyanisolationmembrane(phagophore)BThatmembraneelongatestoformanautophagosomeCTheoutermembraneoftheautophagosomefuseswiththelysosometoformanautolysosomeanddegradetheenclosedmaterialDAlloftheabove第8題Whichofthefollowingiscorrectabout

autophagy?AMicroautophagyreferstothesequestrationofcytosoliccomponentsdirectlybylysosomesthroughinvaginationsintheirlimitingmembraneBInthecaseofmacroautophagy,thecargoesaresequesteredwithinauniquedouble-membranecytosolicvesicle,anautophagosomeCChaperone-mediatedautophagyinvolvesdirecttranslocationofunfoldedsubstrateproteinsacrossthelysosomemembranethroughtheactionofacytosolicandlysosomalchaperonehsc70andtheintegralmembranereceptorLAMP-2ADAlloftheabove第9題Whatistherelationshipbetweenautophagyanddiseases?AAutophagyplaydistinctrolesdependingonspecificorgansBAutohpghagymaybeprotectiveinthedevelopmentofcancerCAutophagymaybeinvolvedinvasculardiseasesDAlloftheabove第10題Howtodetectautophagy?AAutophagosomescanbefoundinthecellsunderelectronmicroscopeBMembraneproteinofautophagosomeLC3-IIisupregulatedduringautophagyCp62degradationcanbeusedtomeasuretheautophagicfluxDAlloftheabove細胞鐵死亡練習(xí)題Exercisesofcellferroptosis第1題Whichofthefollowingiswrongaboutferroptosis?AFerroptsis

isaniron-dependentformofcelldeathBFerroptosisissimilartoclassicalnecrosisCFerroptosisischaracterizedbytoxiclipidROSDFerroptosiscanbesuppressedbyironchelator第2題Whichofthefollowingiscorrectaboutmorphalogicalfeaturesofferroptosis?AFerroptosisdisplaysasshrinkageofmitochondriawithincreaesedmembranedensityBFerroptosis

hasnoDNAcondensationCAutophagosomeisabsentinthecellsundergoingferroptosisDAlloftheabove第3題Howtodetectferroptosis?AFerrousironcontentcanbemeasuredBPhenGreenSKisusedtomeasureferroptosisCROScanbemeasuredincellsundergoingferroptosisDAlloftheabove第4題Whichofthefollowingiscorrectaboutferroptosis?AFerroptosiscanbeinducedbyinhibitionofglutathionebiosynthesis.BFerroptosiscanbetriggeredbysuppressionofGSH-dependentantioxidantenzymeglutathioneperoxidase4(GPX4)CFerroptosisisadistinctformofcelldeathDAlloftheabove第5題ComponentsinvolvedinferroptosisincludesASystemX-cBGPX4andGSHCIronDAlloftheabove第6題WhichofthefollowingiscorrectaboutSystemX-c?ASystemx-cisthecystine/glutamateantiporterBItisaheterodimercomposedofthelightchainsubunitSLC7A11andheavychainsubunitSLC3A2.CSLC3A2regulatestraffickingofSLC7A11totheplasmamembraneDAlloftheabove第7題WhichofthefollowingiscorrectaboutSystemX-c?ASystemXc-modulatesintracellularglutathione(GSH)contenttobalancecellularredoxBItimportsonemoleculeofcystineinexchangeforonemoleculeofintracellularglutamateCSLC7A11mediatestransportactivityofsystemx-c

DAlloftheabove第8題InhibitorsofSystemX-cincludesAErastinBSulfasalazineCSorafenibDAlloftheabove第9題WhichofthefollowingiscorrectaboutGPX4?ATheselenoproteinglutathioneperoxidase4(GPX4,PHGPx)servesasacandidatetargetofRSL3BTherearethreetypesofGPx4,nucleolar(nGPX4),mitochondrial(mGPX4)andnon-mitochondrial(cGPX4)isoformsCNon-mitochondrialGPX4thatplaysimportantrolesinferroptosisprocessDAlloftheabove第10題WhichofthefollowingiscorrectaboutGPX4?AGPX4isaGSH-dependentenzymeBGPX4reducesfromlipidhydroperoxides(LOOH)tolipidalcohols(L-OH).CGPX4decreasesleveloflipidROS.DAlloftheabove第11題WhichofthefollowingiscorrectaboutGSH?AGSHisthereducingsubstrateofGPx4BFerroptosiscanbetriggeredbydeprivingcellsoftheessentialGSHprecursor,cysteineCInhibitionofglutamate-cysteineligasecaninducecelldeathDAlloftheabove細胞重生練習(xí)題Exercisesofcellanastasis第1題Whichofthefollowingiscorrectaboutcelldeath？AActivationofexecutionercaspasesisan“allornone”eventBAfterinitiationofapoptosis,onceexecutionercaspasesareactivated,cellswilldefinitelydieCCellscansurvivesomeextentofexecutionercaspaseactivationunderstressDAlloftheabove第2題Howtomonitortheexecutionercaspaseactivityduringanastasis？AAfluorescentreporterforexecutionercaspaseactivityisused.BInthisreporter,thefluorescentproteinYFPisfusedwithanuclearlocalizationsignalatoneendandanuclearexportsignalandalinkerthatisspecificallyrecognizedandcleavedbycaspase3or7.COncecaspase3or7isactivated,thenuclearexportsignalwillberemovedandYFPwilltranslocateintonucleusDAlloftheabove第3題Whichofthefollowingiscorrectaboutcaspsase3？AItistheexecutionercaspasesduringapoptosis.BItcleavesmanytargetsinthecellsundergoingapoptosis.CDuringapoptosisoncecaspase3wasactivated,itsactivityreachedmaximumwithin20min.DAlloftheabove第4題WhichofthefollowingiscorrectaboutAnnexinV？AAnnexinVisusedtodetectapoptosisBAnnexinVspecificallybindsphosphatidylserineCPhosphatidylserinestaysattheinnersideofplasmamembranebutexposestotheoutersideduringapoptosisDAlloftheabove第5題Whichofthefollowingiscorrectaboutanastasis？AAnastasisisrecoveryfromthebrinkofapoptoticcelldeathBAnastasisisaGreekwordof“risingtolife”.CApoptosisandanastasiscanbeconvertedtoeachotherundercertainconditionsDAlloftheabove第6題Howtodetectanastasisinvivo?AAbiosensorwhichmarksallcellsthathaveundergonecaspaseactivationisdesigned.BInthisbiosensorsystem,thetranscriptionfactorlexAorGal4isfusedtoatransmembranedomainthroughanexecutionercaspasescleavagesite,DQVDCWithoutexecutionercaspaseactivity,thetranscriptionfactoristetheredtothemembraneDAlloftheabove第7題WhichofthefollowingiscorrecttheCasExpressbiosensor？ATheCasExpressbiosensorconvertstransientexecutionercaspaseactivationtopermanentGFPexpression.BCellsmarkedbyCasExpressaremainlythosehaveexperiencedtheexecutionercaspaseactivationandsurviveCCasExpressisaninvivoCaspasesensor.DAlloftheabove第8題Whichofthefollowingiscorrectaboutanastasis？AAnastasiscanoccurinvivoandcontributetoepithelialregenerationafterdamage.BAnastasisalsooccursinresponsetodirectcaspaseactivationCCompensatoryproliferationofundamagedcellsandbyproliferationofanastaticcellsdependsonthetypeofthedamage.DAlloftheabove第9題Whichofthefollowingiscorrectaboutrelationshipbetweenanstasisandtumor？AAnastasisinducedincreaseinmigrationcapacityottumorcellsBAnastasiscellsmaytendtopossessmorestemnessCAnastasismaypromotetumorigenesisDAlloftheabove細胞凋亡與膠質(zhì)瘤練習(xí)題Exercisesofcellapoptosisandglioma第1題WhichofthefollowingiscorrectaboutBCL-2familyandinhibitorofapoptosisproteins?AProteinsoftheBCL-2familyfunctionasregulatingmitochondrialpathwayofapoptosis.BProteinsoftheBCL-2familycanbothsuppressandpromoteapoptosis.CAnti-apoptoticBCL-2orBCL-XLareantisensestrategieswhichledtocelldeathandenhancedchemosensitivityofglioblastomacelllinesinpre-clinicalstudies.DAlloftheabove第2題Whichofthefollowingcelltypesisgliomaderivedfrom?AAstrocytesBOligodendrocytesCNeuralstemcellsDAnyoftheabove第3題Whichofthefollowingiscorrectaboutglioma?AItmayoriginatesthegliacellsBCharacterizedbythespreadofcancertocellswithinthecentralnervoussystemCTheexactcausesofgliomasremainunclearDAlloftheabove第4題GliomasareusuallyperformedbydifferenttreatmentoptionsthatincludeATargetedtherapyBSurgeryCRadiationtherapyandchemotherapyDAlloftheabove第5題Whichofthefollowingiscorrectaboutglioma?AGliomasarecomposedofaheterogenousgroupofneoplasmsBTheyaretraditionallydividedinto4grades(I,II,IIIandIV)basedonhistologictypeandmalignancygrade.CGlioblastomamultiforme(GBM)isthemostmalignantgliomaDAlloftheabove第6題Whichofthefollowingiscorrectaboutimportantpathwaysingliomabiology?ARTK/RAS/PI(3K)BIDHmutationCP53,RbDAlloftheabove第7題Whichofthefollowingiscorrectaboutglioma?ABasedontranscriptionalfeatures,GBMwasclassifiedintofouresubtypes:classical,neural,proneural,andmesenchymal.BResistancetoapoptosisisahallmarkofglioblastomaCGliblastomahavemultiplemechanismstoescapeprogrammedcelldeathinordertomaintaintheirsurvival.DAlloftheabove第8題Whichofthefollowingiscorrectaboutp53?Ap53,theTP53geneproduct,isinvolvedintheregulationofcellcycleandapoptosis.BInglioblastomas,TP53mutationsarecommon.CMDM2andMDM4areresponsibleforinhibitingp53stabilityDAlloftheabove第9題WhichofthefollowingiswrongaboutPTEN?APTENisanoncogeneinGBMBItservesasalipidphosphataseagainstthePI3K/AKT/mTORpathwayCPTENmRNAlevelsaresignificantlyreducedingliomatissuecomparedwithbenignbraintumorsandtumor-adjacentnormaltissuesDThelossofPTENisfrequentinGBM,andthereforeitisdifficulttotargetitfortherapy自噬與膠質(zhì)瘤練習(xí)題Exercisesofautophagyandglioma第1題Whichofthefollowingisnotcorrectabouttheclassicalsubtypeofgloblastoma?AItischaracterizedbyabnormallyhighlevelsofepidermalgrowthfactorreceptor(EGFR)BWithfewornomutationsinTP53CEGFRsuppressesautophagyDNoneofalltheabove第2題Whichofthefollowingisnotcorrectaboutthemesenchymalsubtypeofgloblastoma?AItcontainsthemostfrequentnumberofmutationsinNF1andPTEN.BPTENpositivelyregulatesautophagybyinhibitingthePI3Kpathway,CNF1isanantagonistofRasandnegativeregulatorofmTORDNoneofalltheabove第3題Whichofthefolowingiscorrectabouttheautopagyintheroleoftumor?ATheroleofautophagydependsonthetypeoftumorBTheroleofautophagydependsonthestageoftumorogenesisCTheroleofautophagydependsontheextentoftheinsultDAlloftheabove第4題Whatistheroleoftheautophagyinthetumors?AItdependsonthespecifictumorBItmaypromote

tumorcellsurvivalCItmayleadtotumorcelldeathDAlloftheabove第5題WhichofthefollowingiscorrectabouttheBeclin-1intheglioma?ATheBeclin1proteinisamajorregulatorofautophagyinmammaliancellsBBeclin-1proteinisloweringliobloastomaCBeclin-1mRNAisloweringliobloastomaDAlloftheabove第6題Whichofthefollowingiscorrectaboutthep62?Ap62isareporterofautophagyactivityBAutophagymaysuppresstumorigenesisbyremovingp62-taggedaggregatesCp62accumulationcausesDNAdamageandthegenerationofROSDAlloftheabove第7題Howtounderstandtherelationshipbetweenautophagyandepithelial-to-mesenchymalEMT?AAutophagycaninhibitEMTBEMTistheprocessthatconvertsepithelialcellstomoreinvasivemesenchymalcellsCThedegradationofSnailregulatesEMTDAlloftheabove第8題Whichofthefollowingsupportsautophagyastumorpromotoringlioma?ADownregulationofAtg7,Atg13caninhibitgliomagrowthandoncogenicprogressionBPositivityfortheexpressionofLC3andp62,andautophagywasassociatedwithsignificantlypooreroverallsurvival.CDownregulationofDRAM1andp62canregulatecellmigrationandinvasioninglioblastomastemcellsDAlloftheabove鐵死亡與膠質(zhì)瘤練習(xí)題Exercisesofferroptosisandglioma第1題Whatistherelationshipbetweenp53andferroptosis?AP53downregulatesSLC7A11involvedinferroptosis.BP53limitserastin-inducedferroptosisbyblockingdipeptidyl-peptidase-4(DPP4)activity.CLossofTP53preventsnuclearaccumulationofDPP4.DAlloftheabove第2題WhichofthefollowingiscorrectaboutBAP1?ABRCA1-associatedprotein1(BAP1)encodesanucleardeubiquitinating(DUB)enzyme.BBAP1playsavitalroleintheepigeneticregulationofgenetranscription.CBAP1inhibitscystineuptakebyrepressingSLC7A11expression,leadingtoelevatedlipidperoxidationandferroptosisDAlloftheabove第3題Whichofthefollowingiscorrectaboutfumarase?AAsanenzymeinthemitochondrialTCAcycle,fumarasecatalyzestheconversionoffumaratetomalateBFumaraseenhancesferroptoticcelldeathinresponsetocysteinestarvationCLossoffumaraserelievesferroptosisviainterferencewiththeTCAcycleDAlloftheabove第4題WhichofthefollowingiscorrectaboutNrf2?AThenuclearfactor(erythoid-derived)-like2(Nrf2)iswidelyexpressedinalltissues.BNrf2isakeyregulatorintheseredox-dependenteventsCBothfosteredNrf2expressionandconverselyKeap1inhibitionpromoteresistancetoferroptosisDAlloftheabove第5題WhichofthefollowingiscorrectaboutTemozolomide(TMZ)?ATemozolomide(TMZ)isthefirst-linechemotherapydrugusedtotreatglioma.BTMZmarkedlyinducedxCT,thesubunitofglutamate/cystinetrans-portersystemxc-expressionCGBMtherapywithadrugcombinationofTMZanderastinmaybebeneficialDAlloftheabove第6題WhichofthefollowingiscorrectaboutSLC7A11?ASLC7A11,whichisalsoknownasxCT,regulatestheintracellularglutamateandextracellularcystineexchangeBHighlyexpressedSLC7A11ingliomascontributestotheresistanceofTMZCTheinhibitionofSLC7A11expressioningliomascanreducethelevelofGSHincells,andincreasethesensitivitytoTMZDAlloftheabove第7題WhichofthefollowingiscorrectaboutGPX4?AGPX4functionsasapowerfulantioxidantenzymeinthebodyBTheferroptosisinducerRSL3mainlytriggersferroptosisbyinhibitingtheactivityofGPX4.CTheexpressionofGPX4ingliomasincreaseswiththeincreasinggradesofgliomasDAlloftheabove第8題WhichofthefollowingiscorrectaboutPseudolaricacidB?APseudolaricacidB(PAB)isaditerpeneacidisolatedfromtherootandtrunkbarkofCortexpseudolaricis,BIthasvariousbioactivitiessuchasantimicrobialactivity,antiangiogenicactivityandantivirusactivity.CPABtreatmentcouldleadtodeathinhumancancercellsDAlloftheabove第9題WhichofthefollowingiscorrectaboutPseudolaricacidB?APseudolaricacidB(PAB)inhibitedtheviabilitiesofgliomacellsinvitroandinvivo.BThecellstreatedwithPABpresentedintactmembrane,shrunkenmitochondriawithincreasedmembranedensityCPABimprovedintracellularironbyupregulationoftransferrinreceptorDAlloftheabove第10題WhichofthefollowingiscorrectaboutACSL4?APolyunsaturatedfattyacids(PUFAs)arethemostsusceptiblelipidstoROSdamageinthecourseofferroptosisBAcyl-CoAsynthetaselong-chainfamilymember4(ACSL4)isamemberofthelongchainfamilyofacyl-CoAsynthetaseproteins.CTheexpressionofACSL4wasdownregulatedinhumangliomatissuesandcellsDAlloftheabove細胞自噬與神經(jīng)退行性疾病練習(xí)題Exercisesofcellautophagyandneurodegenerativediseases第1題Whichofthefollowingiscorrectaboutneurodegenerativediseases?APrimarilylossofstructureorfunctionofneuronsBOftenoccursinthelaterstageoflifeCProgressivedegenerationofthestructureandfunctionofthecentralnervoussystemorperipheralnervoussystemDAlloftheabove第2題Alzheimer’sdisease(AD)patientshavethefollowingcharacteristicsAInearlyAD,atrophyisseenprimarilyintheentorhinalcortexandthehippocampus.BAsADprogresses,atrophyspreadstotherestofthemedialtemporallobe(MTL)includingthemedialtemporal,parahippocampalregionsandfusiformgyriCEventually,atrophyprogressestotherestofthecortex,primarilythetemporal,parietal,andfrontallobes.DAlloftheabove第3題WhichofthefollowingiscorrectaboutAD?AAsatrophyprogresses,thecerebrospinalfluid(CSF)spaces(eg,ventricles,cerebralsulci,andcerebellarfolia)alsoenlarge.BExtracellularaggregationofproteinAβisonehallmarkofADCIntracellularaggregationofTauisanotherhallmarkofADDAlloftheabove第4題Whichofthefollowingiscorrectaboutubiquitin-proteasomepathway?AUbiquitin-proteasomepathwayisusedtoclearmutantproteinsfoundintheneurodegenerativediseases.BThemisfoldedproteinsareubiquitinatedbyseriesofenzymeswhichattachthesmallmoleculeubiquitintothelysineoftargetproteinsCMoreubiquitinsarethenattachedtoformaladderofubiquitinthatservesasarecognitionsignalfordegradationDAlloftheabove第5題Whichofthefollowingiscorrectaboutneuronalautophagy?ANeuronsarehighlypolarizedincludingdendritesandaxons..BAutophagosomesformfromdistalterminalofaneuronCAutophagosomeareretrogradelytransportedtosomaDAlloftheabove第6題Whichofthefollowingiscorrectaboutneuronalautophagy?ATheautolysosomeareformedduringthetransportationofautophagosomesalongtheaxonBAutophagosomesbecomemorematuredwhenmovednearthesomaCThematurationofautophagosomesisspatiallyandtemporallyregulatedalongtheaxon.DAlloftheabove第7題Whichofthefollowingiscorrectabout

neuronalautophagy?AInnormalconditions,neuronalautophagyisvitalformaintainingneuronalhomeostasis,membranerecycling,presynapticfunctionetcBIfautophagyisdysregulated,mutantproteinaggregatesresultsinatoxiceffectofcellulardamage.CBlockadeofautophagyinAtg5-andAtg7-deficientmiceleadtotheappearanceofinclusionbodiesaccumulatedinthecerebralcortexandthecerebellumDAlloftheabove第8題WhichofthefollowingiscorrectaboutAlzheimer'sDisease(AD)?AADisprobablythemostcommonlyknownneurodegenerativedisease.BThemostprominentsymptomsofADarethememorylossandcognitivedecline.CADpatientshavechangesinmoodandpersonalitychanges.DAlloftheabove第9題WhichofthefollowingiscorrectabouttherelationshipbetweenautophagyandAD?AAutophagyinADisdisrupted.BHigheraccumulationofautophagicvacuolesinprefrontalcortexcanbefoundinAD.CAutophagicvacuoleswereuncommoninbrainsdevoidofADpathologyDAlloftheabove第10題WhichofthefollowingiscorrectabouttherelationshipbetweenautophagyandAD?AAtg7,Beclin1aredecreasedexpressioninADpatientandtransgenicmouseBLysosomalhydrolasesareincreasedandabnormallydistributedinADbrainsandADmousemodelsCCathepsinD(CTSD),enzymeinprocessingofAβpeptidesandclearanceofamyloidplaqueswasdecreasedinADpatientsDAlloftheabove第11題Whichofthefollowingiscorrectabout

AD?AAβisproducedbysequentialcleavageoftheamyloidprecursorprotein(APP)BInhibitingmTORsignallingwithrapamycin

reducedAβandTauproteinpathologyandsignificantlyrescuedcognitiveimpairmenCHeterozygousdeletionofautophagyinitiatingBeclin1

increasesintracellularandextracellularAβdepositionsDAlloftheabove細胞凋亡與自閉癥練習(xí)題ExercisesofcellapoptosisandASD第1題Whichofthefollowingiscorrectaboutautismspectrumdisorder(ASD)?AAutism,orautismspectrumdisorder(ASD),referstoabroadrangeofconditionscharacterizedbychallengeswithsocialskills,repetitivebehaviors,speechandnonverbalcommunicationBAutismaffectsanestimated1in59childrenintheUnitedStatestodayCAutismisadevelopmentaldisorderDAlloftheabove第2題SymptomsofASDincludesAPersistentdeficitsinsocialcommunicationandsocialinteractionacrossmultiplecontextsBRestricted,repetitivepatternsofbehavior,interes