第1題Whichofthefollowingdiseasescouldbetreatedbythe"Glenin"inthemovie"Dyingtosurvive"?AHeartdiseaseBLeukemiaCCerebrovasculardiseaseDCirrhosis第2題Inadditiontobeingabletospeeduptargetdiscovery,whatistheotheradvantageofCADD?AIncreasedrugtargetsBImprovetheinclusionoftargetsCFindmoretargetsDImprovetheaccuracyoftargetdiscovery第3題WhatarethemainproblemsofCADDatpresent?AAuthenticityandusabilityofthree-dimensionalproteinstructureBThewayofreceptorligandinteractionCWhetherthedesignedmoleculecanbechemicallysynthesizedDDrugtransport,metabolismandsideeffectsinvivo正確答案：ABCD第4題Computeraideddrugdesignusespharmacophoremodels,quantummechanics,moleculardynamics,thequantitativestructure-activityrelationship(QSAR),etc,onenzymeorreceptor,soastoachievethepurposeofdrugdesign.第5題Atpresent,anewdrugcanbedesignedautomaticallybycomputer.第6題Aleadcompoundindrugdiscoveryisachemicalcompoundthathaspharmacologicalorbiologicalactivityandwhosechemicalstructureisusedasastartingpointforchemicalmodificationsinordertoimprovepotency,selectivity,orpharmacokineticparameters.第1題Whatarethetargetsofdrugaction?ARecipientBionchannelCenzymeDEndogenoussmallmolecularmatter正確答案：ABCD第2題Whichofthefollowingareendogenousligandsofreceptors?ANeurotransmitterBhormoneCAutoactivesubstanceDMycoplasma正確答案：ABC第3題Whatarethecharacteristicsofreceptors?ASpecificityBHighaffinityCSaturabilityDReversibility正確答案：DCBA第4題Thespecificityofdrugactiondependsonthespecificityofdrugmoleculebindingtoitsreceptor.第5題Moderndrugdiscoveryalsohasitslimitations.Itsresearchobjectis"drug-disease"relationshipratherthan"target-drug"relationship.第6題Thesubstancesthatcanspecificallybindtothereceptorsinthebodyarecalledligands.第7題Thereceptoristhebiomacromoleculethatcaninteractwithdrugsandinitiatecellreaction.Unittest3第1題WhatisthemostcommonmethodusedtobuildQSARmodel?ASimplexalgorithmBPartialleastsquaremethodCleastsquaremethodDsamplemethod第2題WhichofthefollowingparametersarecommonlyusedinQSAR?AStereoparametersBStructuralparametersCIndicatorvariableDElectricalparameters正確答案：ABCD第3題Molecularfieldanalysisassumesthatthebindingofligandandreceptoriscovalent,andtheiraffinityorbiologicalactivityisrelatedtothethree-dimensionalorelectrostaticfieldaroundtheligandmolecule.第4題Whatarethedockingmethodssuitableforstudyinglargesystems?ARigiddockingBSemi-flexibledockingCFlexibledockingDSemi-rigiddocking第5題Thebindingabilityofdrugtoreceptordependsonthechangeofbindingfreeenergy.第6題Whichofthefollowingmoleculardockingmethodsisunnecessarytoconsiderthemolecularstructurecharacteristics?AFlexibledockingBSemi-flexibledockingCRigiddockingDSemi-rigiddocking第7題Amongthefollowingoptions,whatproblemsneedtobesolvedindockingmethod?ASolvationeffectBMolecularflexibilityCScoringfunctionDConformationalselection正確答案：ABC第8題WhichofthefollowingdescriptionofthepharmacophoreiscorrectAIt'stheatomsinvolvedintheactivityofthedrugBIt'safunctionalgroupassociatedwithdrugactivityCIt'sanactivesubstituentDIt'sacombinationofthreedimensionalstructuralelementsthatcanberecognizedandboundbythereceptor第9題Theresultofsequencealignmentcanbeusedastheabsoluteevidenceofhomologybetweenthem.Unittest4第1題Homologymodelingmeansthatifasequenceisfoundtohave(

)withanotersequenceofknownthree-dimensionalstructure,thenyoucanusetheknownstructuretopredictunknownthree-dimensionalstructurebyhomologymodelingASimilarityBHomologyCUniformityDComparability第2題Homologousmodelingisoftenusedinproteinstructureprediction.Besidesabinitioprediction,whatistheothermethod?ASpecificconfigurationmethodBReversefoldingCFragmentmethodDReferenceconstructionmethod第3題Proteinsneedtobecorrectlyfoldedintoaspecificconfigurationinordertoperformtheirnormalfunctions.第4題AmongtheQSARfittingcorrelationcoefficients,therearethreeparametersincludingcorrelationcoefficientsR,standarddeviationSandFtestvalues.Whichofthefollowingstatementiscorrect?AThelargerRandF,thesmallers,indicatingthatthemodelfitsbetterBThesmallerRandF,thelargers,indicatingthestrongerthemodel'sfittingabilityCThesmallerRis,thelargerFis,andthesmallersis,indicatingthatthemodelfitsbetterDThesmallerRis,thelargerFis,andthelargersis,indicatingthatthemodelfitsbetter第5題TheassumptionofCoMSIAmethodissimilartothatofCoMFAmethod,thatis,thecovalentinteractionbetweenligandandreceptorisdeterminedbymolecularfield.第6題Samplemethodreferstotheuseofsampledistancepartialleastsquare(sampls)todeterminethecrossvalidationR2ofleave-one-out.第7題Structuraloptimizationistodeterminethelow-energyconformationofmolecular,whichiscorrespondingtothemaximumvalueofthemolecularpotentialenergysurface.Thisprocessiscalledenergyoptimization.第8題Whichofthefollowingmethodscouldbeusedtotherigidmoleculardocking?AMethodbasedonmaximumgroupsearchBMethodbasedongeometrichashingtechnologyCMethodbasedonposeclusteringDMethodbasedonHowardrule正確答案：CBA第9題TheflexibledockingmethodincludeswhichofthefollowingmethodsAEnse