1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEDGAT-1 inhibitor 2Cat. No.: HY-50670CAS No.: 942999-61-3分式: CHNO分量: 420.5作靶點: Acyltransferase作通路: Metabolic Enzyme/Protease儲存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實驗 DMSO : 25 mg/mL (59.45 mM

2、; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 2.3781 mL 11.8906 mL 23.7812 mL5 mM 0.4756 mL 2.3781 mL 4.7562 mL10 mM 0.2378 mL 1.1891 mL 2.3781 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。體內(nèi)實驗 請根據(jù)您的實驗動物和給藥式選擇適當?shù)娜芙獍福渲魄罢埾扰渲瞥吻宓膬湟海僖来翁砑又軇?為保證實驗結果的可靠性，體內(nèi)實驗的作液，建議您現(xiàn)現(xiàn)配，當天使；澄清的儲備液

3、可以根據(jù)儲存條件，適當保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (5.95 mM); Suspended solution; Need ultrasonic2. 請依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (5.95 mM); Clear solution3. 請依序添加每種溶劑： 10% DMSO 90% corn oilSolu

4、bility: 2.5 mg/mL (5.95 mM); Clear solution1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemEBIOLOGICAL ACTIVITY物活性 DGAT-1 inhibitor 2是有效的DGAT-1抑制劑，具有減肥功效。REFERENCES1. Matsuda D, Tomoda H. DGAT inhibitors for obesity. Curr Opin Investig Drugs. 2007 Oct;8(10):836-41.2. Birch, Alan M.; Birtles, Susan;

5、Buckett, Linda K. et al. Discovery of a Potent, Selective, and Orally Efficacious PyrimidinooxazinylBicyclooctaneacetic Acid Diacylglycerol Acyltransferase-1 Inhibitor. Journal of Medicinal Chemistry (2009), 52(6), 1558-1568.3. King AJ, Judd AS, Souers AJ. Inhibitors of diacylglycerol acyltransferas

6、e: a review of 2008 patents. Expert Opin Ther Pat. 2010Jan;20(1):19-29.4. Cao J, Zhou Y, Peng H et al. Targeting Acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1) with small molecule inhibitors for thetreatment of metabolic diseases. J Biol Chem. 2011 Dec 2;286(48):41838-51.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400