1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemERCGD423Cat. No.: HY-114775CAS No.: 108237-91-8分式: CHBrNS分量: 331.23作靶點(diǎn): Interleukin Related作通路: Immunology/Inflammation儲(chǔ)存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 160 mg/mL (483.05 mM)H2

2、O : 40% PEG300 5% Tween-80 45% salineSolubility: 2.67 mg/mL (8.06 mM); Clear solution2. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.67 mg/mL (8.06 mM); Suspended solution; Need ultrasonic1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemE3. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% corn oilSolubility: 2

3、.67 mg/mL (8.06 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 RCGD423gp130 調(diào)節(jié)劑，能夠阻關(guān)節(jié)軟退化，并促進(jìn)其修復(fù)。IC50 & Target gp130 1體外研究 RCGD423 is a gp130 modulator, which prevents articular cartilage degeneration and promotes repair 1.體內(nèi)研究 RCGD423 greatly reduces chondrocyte hypertrophy, loss and degeneration while i

4、ncreasing chondrocyteproliferation beyond that observed in response to injury in a rat partial meniscectomy model. Moreover,RCGD 423 improves cartilage healing in a rat full-thickness osteochondral defect model, increasingproliferation of mesenchymal cells in the defect and also inhibiting breakdown

5、 of cartilage matrix in de novogenerated cartilage 1.REFERENCES1. Shkhyan R, et al. Drug-induced modulation of gp130 signalling prevents articular cartilage degeneration and promotes repair. AnnRheum Dis. 2018 May;77(5):760-769.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 021-58