Hotline:400-820-3792Inhibitors?Agonists?ScreeningLibrarieswww.MedChemECR-1-31-BCat.No.:HY-136453CASNo.:1352914-52-3分?式:C??H??NO?分?量:507.53作?靶點(diǎn):EukaryoticInitiationFactor(eIF)作?通路:CellCycle/DNADamage儲(chǔ)存?式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性數(shù)據(jù)體外實(shí)驗(yàn)DMSO:300mg/mL(591.10mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制備儲(chǔ)備液1mM1.9703mL9.8516mL19.7033mL5mM0.3941mL1.9703mL3.9407mL10mM0.1970mL0.9852mL1.9703mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存?式和期限。BIOLOGICALACTIVITY?物活性CR-1-31-B?種有效的eIF4ARNA螺旋酶(eIF4ARNAhelicase)抑制劑。CR-1-31-B阻斷乳腺癌細(xì)胞對(duì)?長因?刺激的MUC1-C翻譯。體外研究CR-1-31-B(100nM;24hours)inhibitsMUC1-CtranslationinMCF-10Acells[1].CR-1-31-B(10and100nM)decreasesMUC1-CabundanceinMDA-MB-468breastcancercells[1].WesternBlotAnalysis[1]1/2MasterofSmallMolecules—您?邊的抑制劑?師www.MedChemECellLine:MCF-10Acells(EGF/HRGstimulated)Concentration:100nMIncubationTime:24hoursResult:EGF-stimulatedMCF-10Acellswasassociatedwithadose-dependentdecreaseinMUC1-Cabundance;BlockedHRG-inducedincreasesinMUC1-Cabundance.REFERENCES[1].JinC,RajabiH,RodrigoCM,PorcoJAJr,KufeD.TargetingtheeIF4ARNAhelicaseblockstranslationoftheMUC1-Concoprotein.Oncogene.2013;32(17):2179-2188.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792ax