Hotline:400-820-3792Inhibitors?Agonists?ScreeningLibrarieswww.MedChemEUNC10217938ACat.No.:HY-136151CASNo.:1347749-97-6分?式:C??H??N?O?分?量:456.54作?靶點(diǎn):Others作?通路:Others儲(chǔ)存?式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性數(shù)據(jù)體外實(shí)驗(yàn)DMSO:10mg/mL(21.90mM;ultrasonicandwarmingandheatto80°C)MassSolvent1mg5mg10mgConcentration制備儲(chǔ)備液1mM2.1904mL10.9519mL21.9039mL5mM0.4381mL2.1904mL4.3808mL10mM0.2190mL1.0952mL2.1904mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存?式和期限。體內(nèi)實(shí)驗(yàn)請(qǐng)根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥?式選擇適當(dāng)?shù)娜芙?案，配制前請(qǐng)先配制澄的儲(chǔ)備液，再依次添加助溶劑(為保證實(shí)驗(yàn)結(jié)果的可靠性，體內(nèi)實(shí)驗(yàn)的?作液，建議您現(xiàn)?現(xiàn)配，當(dāng)天使?；澄的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；以下溶劑前的百分?指該溶劑在您配制終溶液中的體積占?)：1.請(qǐng)依序添加每種溶劑：10%DMSO>>40%PEG300>>5%Tween-80>>45%salineSolubility:≥1mg/mL(2.19mM);ClearsolutionBIOLOGICALACTIVITY?物活性UNC10217938A?種具有強(qiáng)?的寡核苷酸(oligonucleotides)增強(qiáng)作?的3-deazapteridine類似物。1/2MasterofSmallMolecules—您?邊的抑制劑?師www.MedChemEUNC10217938A通過調(diào)節(jié)寡核苷酸的細(xì)胞內(nèi)運(yùn)輸和從內(nèi)體釋放來增強(qiáng)寡核苷酸的作?。UNC10217938A還增強(qiáng)了反義和siRNA寡核苷酸的作?。體外研究UNC10217938AstronglyenhancesluciferaseinductioninHelaLuc705cellswhenusedinthe5-25μMrangeandaresubstantiallymoreeffectiveandpotentthanRetro-1.Ascomparedtospliceswitchingoligonucleotide(SSO)alone,UNC10217938Aprovidsa60-foldenhancementat10μMand220-foldat20μM,incontrasttoa11-foldenhancementfor100μMRetro-1[1].UNC10217938Acansubstantiallyenhanceeffectsofreceptortargetedoligonucleotideconjugates.UNC10217938Aalsocanenhanceeffectsofunchargedmorpholinooligonucleotidesaswellasnegativelychargedoligonucleotides[1].ExposureofcellstoUNC10217938Aleadstoamajorreductioninco-localizationoftheTAMRA-oliogonucleotidewiththelateendosomemarkerRab7,buthadlittleeffectonco-localizationwiththelysosomalmarkerLAMP-1.UNC10217938Acausespartialreleaseofoligonucleotidefromlateendosomestothecytosolfollowedbynuclearaccumulation[1].體內(nèi)研究SystemictreatmentwithSSO623followedbyadministrationofUNC10217938A(7.5mg/kg;intravenousinjection)producesdistinctincreasesinEGFPfluorescenceinliver,kidneyandheartinEGFP654mice[3].REFERENCES[1].YangB,etal.High-throughputscreeningidentifiessmallmoleculesthatenhancethepharmacologicaleffectsofoligonucleotides.NucleicAcidsRes.2015Feb27;43(4):1987-96.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forres