Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEKDU731Cat.No.:HY-103583CASNo.:1610610-48-4分?式:C??H??N?O?分?量:396.4作?靶點:PI4K;Parasite作?通路:PI3K/Akt/mTOR;Anti-infection儲存?式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性數(shù)據體外實驗DMSO:83.33mg/mL(210.22mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制備儲備液1mM2.5227mL12.6135mL25.2270mL5mM0.5045mL2.5227mL5.0454mL10mM0.2523mL1.2614mL2.5227mL請根據產品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；?旦配成溶液，請分裝保存，避免反復凍融造成的產品失效。儲備液的保存?式和期限：-80°C,6months;-20°C,1month。-80°C儲存時，請在6個?內使?，-20°C儲存時，請在1個?內使?。BIOLOGICALACTIVITY?物活性KDU731，具有?服活性的C.parvumPI4K抑制劑，阻斷體內外隱孢??感染，IC50值為25nM。KDU731是研究隱孢??引起的腹瀉的有望候選藥物，具有?泛的安全性。IC50&TargetPI4K1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemE體內研究KDU731(orallyadministration;7or10mg/kg;16days)haspotentactivityagainstCryptosporidiuminimmunocompromisedIFN-γKOmiceanddramaticallyreducesoocystshedding[2].KDU731(orallyadministration;5mg/kg;every12hoursfor7days)istoleratedinallcalves,andtreatedcalvesshedsignificantlyfeweroocyststhanvehicletreatedcalvesintheirstool[2].AnimalModel:6-8weekoldC57BL/6IFN-γ-knockoutmicewith10,000oocysts[1]Dosage:7or10mg/kgAdministration:Orallyadministration;7or10mg/kg;16daysResult:Resultedinsignificantreductionofoocystshedding.AnimalModel:Neonatalcalveswith5x107oocysts[1]Dosage:5mg/kgAdministration:Orallyadministration;5mg/kg;every12hoursfor7daysResult:Resultedinsignificantreductionofoocystsheddingintreatedcalvesintheirstool.REFERENCES[1].WardHD,etal.NewToolsforCryptosporidiumLeadtoNewHopeforCryptosporidiosis.TrendsParasitol.2017Sep;33(9):662-664.[2].ManjunathaUH,etal.ACryptosporidiumPI(4)Kinhibitorisadrugcandidateforcryptosporidiosis.Nature.2017Jun15;546(7658):376-380.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-