Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEApoptosisinducer46Cat.No.:HY-178132CASNo.:3085356-41-5分?式:C??H??NO?分?量:375.46作?靶點:Apoptosis;NF-κB作?通路:Apoptosis;NF-κB儲存?式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY?物活性Apoptosisinducer46?種凋亡(apoptosis)誘導(dǎo)劑。Apoptosisinducer46對轉(zhuǎn)移性三性乳腺癌(TNBC)細胞具有強效且選擇性的?長抑制作?。Apoptosisinducer46在MDA-MB-231細胞中誘導(dǎo)G2/M期細胞周期阻滯和凋亡(apoptosis)細胞死亡，并阻斷NF-κB的核轉(zhuǎn)位。Apoptosisinducer46可?于三性乳腺癌(TNBC)研究[1]。體外研究Apoptosisinducer46(Compound5d)(96h)exhibitspotentgrowthinhibitoryeffectsonmetastatictriple-negativebreastcancer(TNBC)MDA-MB-231,HCC1806,MCF-7,BEAS2BcellswithIC50sof0.38μM,0.31μM,0.39μM,0.7μM,respectively[1].Apoptosisinducer46(5-40μM,2-4h)significantlyreducesproteasomeactivityinMDA-MB-231cellswithanIC50of37.0μMforproteasomeinhibition,andinducesaccumulationofubiquitinatedproteins[1].Apoptosisinducer46(5μM,24-72h)increasestheapoptosisrateandcausesprogressiveaccumulationofMDA-MB-231cellsintheG2/Mphaseofthecellcycle[1].Apoptosisinducer46(5-20μM)stabilizescyclinD1,p53,andp21proteins,preventsdegradationofIκBα,IκBε,andIκKγ,andinhibitsnucleartranslocationofNF-κBinMDA-MB-231cells[1].ApoptosisAnalysis[1]CellLine:MDA-MB-231cellsConcentration:5μMIncubationTime:24,48,72hResult:IncreasedtheapoptosisrateofMDA-MB-231cells.1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemECellCycleAnalysis[1]CellLine:MDA-MB-231cellsConcentration:5μMIncubationTime:24,48,72hResult:CausedprogressiveaccumulationofMDA-MB-231cellsintheG2/Mphaseofthecellcycle.REFERENCES[1].KhorPY,etal.DiscoveryofNewNon-SymmetricalHeterocyclicPentanoidDerivativesTargetingMetastaticTriple-NegativeBreastCancer.BioorgMedChemLett.2025Aug1;123:130232.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400