注：不含主觀題第1題單選題(10分)Architectureofthescaffoldhastomimicthescaleofthe(),creatinganartificialmicroenvironment.AcellmorphologyBextracellularmatrixCcellmigrationDcellcytoplasm第2題判斷題(10分)Topographyofthescaffoldsregulatesthebehaviorofthecells.第3題多選題(10分)()canbeusedasscaffoldsintissueengineering.AcalciumphosphatesandbioactiveglassesBmetalorganicandhybridsCcompositematerialsDnanoparticles正確答案：ABCD第4題判斷題(10分)Oraltissueshaveastrongabilitytoregeneratewhentheoriginaltissueintegrityhasbeenseverelydamaged.第5題填空題(10分)Thecellsusedfororaltissueregenerationare____.正確答案：:["mesenchymalstemcells"]第6題單選題(10分)Mesenchymalstemcellswerefirstisolatedfrom()AbonemarrowBtoothpulpCperiodontalligamentDgingivalconnectivetissue第7題多選題(10分)Theadvantagesoforalmesenchymalstemcellsoverbone-marrowderivedmesenchymalstemcellsinoraltissueregenerationinclude().AeasyaccessBlesstraumaticinterventionsChighpotentialtoregenerateintraoraltissuesDlowerimmunogenecity正確答案：ABC第8題多選題(10分)Thebonemarrowbiopsyformesenchymalstemcellisolationalsoinclude().AhematopoieticprogenitorcellsBbloodcellsCendothelialprogenitorcellsDplatelets正確答案：ABCD第9題單選題(10分)()arethemostcriticalcomponentintissueengineeringandregenerativemedicine.AscaffoldsBsignalmoleculesCcellsDvessels第10題判斷題(10分)Oraltissueshaborstemcells.課后作業(yè)第1題多選題(3.5分)Itisextremelydifficulttoregeneratedamagedtoothstructuresbecause().Ainthetooth,thenumberofstemcellswithahighregenerativecapacityislimitedBdentaltissuesarehighlymineralizedCthepulpchamberbecomessmallerwithageorcalcificationofthepulpDtheenamelformingameloblastsarenolongerpresentaftertootheruption正確答案：ACD第2題多選題(3.5分)Theconceptualtriadoftissueengineeringincludes().AessentialnutrientsBregenerativecellsCsupportingscaffoldsDbioactivemolecules正確答案：BCD第3題判斷題(3分)Thescaffoldsappliedintissueengineeringshouldmimicthecharacteristicsofthetargettissueinbiologicalactivity,mechanicalintegrityandfunctionality.第4題多選題(3.5分)Bioactivemoleculesappliedintissuenengineeringinclude().AgrowthfactorsBtranscriptionfactorsCessentialaminoacidsDsynthesizedchemicalswhichcanorchestratetissuehealing正確答案：ABD第5題判斷題(3分)Theenamelorganandthedentalfolliclearebothderivedfromtheectoderm.第6題多選題(3.5分)Enamelisthehardesttissueinthebodybecause().Afullyformedenameliscomposedofapproximately96%inorganicmineralsBtheprismsandtheinterprismaticsubstancearehighlyorganizedCtheenamelisderivedfromtheectodermDtheenameliscomposedofhydroxyapatite正確答案：AB第7題判斷題(3分)Thecellprocessesoftheodontoblastssynthesizeglycoproteins,whichweretransportedtothecellbodiesandthensecretedtoformthepredentinmatrix.第8題單選題(3.5分)()isformedfromapre-existingodontoblastinresponsetoamildstimulus.APrimarydentinBSecondarydentinCReactionarydentinDReparativedentin第9題判斷題(3分)Terminaldifferentiationofthecellsusuallycoincideswithincreasedproliferationrate.第10題單選題(3.5分)Theconversionofonematurecellularphenotypetoanotherisreferredtoas().AdedifferentiationBredifferentiationCtransdifferentiationDsecondarydifferentiation第11題判斷題(3分)Ameloblastinisanameloblastspecificprotein,andcanbeusedasamarkerforameloblastdifferentiation.第12題單選題(3.5分)Ingeneral,enamelrodsruninaperpendiculardirectiontotheenamelsurface,andinter-rodenamelisatanangleofapproximately()totheenamelrods.A45°B60°C90°D135°第13題填空題(3分)Analysesindicatedthata

____monthrecallisprobablytheminimaltimetojudgeradiographicevidenceofrootdevelopmentinclinicalrevascularizationcases.正確答案：:["12-18"]第14題填空題(3分)Inclinicalendodonticrevascularizationcases,thenumberofappointmentsisatleast____.正確答案：:["2"]第15題多選題(3.5分)Themainmethodsofregenerativeendodonticinclude().ApulprevascularizationBcellhomingCstemcelltransplantationDcelldifferentiation正確答案：ABCD第16題判斷題(3分)Currently,pulprevascularizationandstemcelltransplantationhavebeenappliedclinically,whilecellhominghasnotbeenappliedinclinicalpractice.第17題填空題(3分)____andapexificationarethetreatmentmodalitiesforanimmaturetoothwithpulpnecrosisandapicalperiodontitis.正確答案：:["Regenerativeendodontics"]第18題多選題(3.5分)Basedontheirabilitytodifferentiate,thestemcellscanbedividedinto()stemcells.AomnipotentBtotipotentCpluripotentDmultipotent正確答案：BCD第19題單選題(3.5分)Forcedexpressionoffourtranscriptionfactorsinmurinefibroblastscanreprogramthesesomaticcellsto().AembryonicstemcellsBmesenchymalstemcellsCadultstemcellsDinducedpluripotentstemcells第20題多選題(3.5分)Dentalpulpstemcellscanbeisolatedusing().AenzymaticdigestionBsuspensioncultureCexplantmethodDco-culturewithepithelialcells正確答案：AC第21題多選題(3.5分)Comparedwiththetraditionalapexification,pulprevascularizationhastheadvantagesof().AinducingrootdevelopmentBapicalforamenclosureCrootcanalwallthickeningDcementumformation正確答案：ABC第22題判斷題(3分)ESEadvocatesthatintheabsenceofstrongevidence,theuseoftraditionalCa(OH)2intracanalmedicationinpulpregenerationtreatmentshouldbeavoided,andtheantibioticsisrecommended.第23題多選題(3.5分)Themorphologicstagesoftoothdevelopmentinclude().AbudstageBcapstageCcrownstageDbellstage正確答案：ABD第24題判斷題(3分)toothdevelopmentisregulatedbyaseriesofreciprocalinteractionsinvolvingbothectodermalandmesenchymalstemcells.第25題多選題(3.5分)Theapproachesofpulpregenerationinclude().AregeneratinganentiretoothBregenerationgperiodontaltissueCregeneratingafunctionalpulp-dentincomplexDregenerationalveolarbone正確答案：AC第26題多選題(3.5分)Thestructureofdentalpulpinclude().AodontoblastlayerBcell-poorzoneCcell-richzoneDpulpproper正確答案：ABCD第27題單選題(3.5分)Mostcommonly,theculturemediumissupplementedwitha()concentrationoffetalbovineserum(FBS)forbothisolationandexpansionofdentalpulpstemcells.A1-5%B5-10%C10-20%D20-40%第28題單選題(3.5分)()isrecommendedforneurogenicdifferentiationofdentalpulpstemcells.ASerum-freeculturemediumBSerum-richculturemediumCSphere-formingcultureDCo-culturesystems第29題多選題(3.5分)Cellco-culturesystemsinclude().Adirectcellco-cultureBorgancultureCtranswellsystemDtheuseofconditionedmedium正確答案：ACD第30題判斷題(3分)Thedentalpulpisanendorganwithabundant

collateralcirculation.課后作業(yè)第1題判斷題(3分)Evenunderbasalconditionswithoutanystimulationtowarddifferentiation,osteogenicandchondrogenicmarkersarestilldemonstratedbySHEDs.第2題多選題(3.5分)Exfoliatedteethmaybeanunexpecteduniqueresourceforstem-celltherapiesbecause().AStemcellsfromhumanexfoliateddeciduousteeth(SHED)arecapableofdifferentiatingintomultilineageprogenies.BStemcellsfromhumanexfoliateddeciduousteeth(SHED)havebetterdifferentiationcapabilityinosteogenesisandadipogenesisthanDPSCs.CStemcellsfromhumanexfoliateddeciduousteeth(SHED)canbeisolatedfromexfoliatedprimaryteeth.DStemcellsfromhumanexfoliateddeciduousteeth(SHED)possessedstem-cellcharacteristics.正確答案：ABCD第3題判斷題(3分)Stemcellsfromhumanexfoliateddeciduousteeth(SHED)candifferentiateintofunctionalneuronsinvivo.第4題判斷題(3分)SHEDexpressedstrongerpluripotentmarker,OCT-4,Nanog,andSox-2,comparedtoDPSC.第5題多選題(3.5分)Gingivalmesenchymalstemcells(GMSC)andtheirderivativecell-freeproductsexertpotentregenerativeandtherapeuticpotentialsin().AskindisorderBautoimmuneandinflammatorydiseaseCoralandmaxillofacialdisorderDnerveregeneration正確答案：ABCD第6題單選題(3.5分)()arerelativelyresistanttoirradiationorchronicperiapicalinflammationthanotherdentalMSCs,AGingivalmesenchymalstemcells(GMSC)BStemcellsfromtheapicalpapilla(SCAP)CStemcellsfromhumanexfoliateddeciduousteeth(SHED)Ddentalpulpstemcells(DPSC)第7題判斷題(3分)Dentinmatrixacidicphosphoprotein1(DMP1)ishighlyexpressedindentalfolliclestemcells(DFSC).第8題單選題(3.5分)CD24,anothermarkerforthepluripotentpopulation,isregardedasarepresentativesurfacemarkerfor().APeriodontalligamnetstemcells(PDLSC)BGingivalmesenchymalstemcells(GMSC)CStemcellsfromtheapicalpapilla(SCAP)DStemcellsfromhumanexfoliateddeciduousteeth(SHED)第9題多選題(3.5分)Sub-populationofstemcellsfromtheapicalpapilla(SCAP)areableto().Aexpressneuronalcell-associatedmarkersBsecretesomeneurotrophic,neuroprotectivefactorsChaveangiogenicfunctionDhavelongertelomerelength正確答案：ABCD第10題多選題(3.5分)Therationalefortheapplicationofgrowthfactorstotheperiodontaldefectisbasedontheirabilityto().AstimulatecellproliferationBpromotecelldifferentiationCincreaseapoptosisDinfluencekeycellularfunctions正確答案：ABD第11題填空題(3分)____aretemporarilydepositedontothedentinalrootsurfaceandprovideaninitialandessentialstepintheformationofacellularcementum.正確答案：:["Enamelmatrixproteins"]第12題單選題(3.5分)Themajorfractionoftheenamelmatrixproteinsis().AenamelinsBamelogeninsCtuftelinDtuftproteins第13題判斷題(3分)Intheabsenceofmineralizationenhancerβ-glycerophosphateanddexamethasone,enamelmatrixproteins(EMPs)cannotresultinasignificantlyhighernumberofvonKossastainedclonesofPDLSC.第14題多選題(3.5分)Enamelmatrixproteins(EMPs)areableto().ApromotePDLcellproliferationBincreasePDLcellattachmentCpromoteepithelialcellproliferationDincreasePDLcellmetabolism正確答案：ABD第15題單選題(3分)()favoursmesenchymalcellgrowthoverepithelium.AEnamelmatrixderivatives(EMD)Bbonemorphogenicproteins(BMPs)Cvascularendothelialgrowthfactor(vEGF)Dplatelet-derivedgrowthfactor(PDGF)第16題多選題(3.5分)Platelet-derivedgrowthfactor(PDGF)playsanimportantroleinarangeofbiologicalevents,evidencedby().APDGFisanextraordinarilypotentmitogenformostmesenchymalderivedconnective-tissue-formingcells.BPDGFpromoteproliferationoffibroblasts,smoothmuscle,orglialcells.CPDGFischemotactic.DPDGFinducesincreasedsynthesisofRNAandproteininconnective-tissue-formingcells.正確答案：ABCD第17題多選題(3.5分)Gingivalconnectivetissues,periodontalligamentandregeneratedtissuespositivelyexpress().APDGFbeta-receptorBPDGFalphareceptorCTGF-betareceptorIDTGF-betareceptorII正確答案：ACD第18題多選題(3.5分)Forthedescriptionofperiodontalregeneration,thecorrectare().APeriodontalregenerationisdefinedasthereproductionorreconstitutionofalostorinjuredpart.BPeriodontalregenerationrequiresnewattachmenttotherootsurface.CPeriodontalregenerationinvolvestheregenerationofprincipalfibres,butnotnecessarytheinsertionofthesefibresintonewlyformedcementumonarootsurface.DPeriodontalregenerationistheultimategoalofperiodontaltreatment.正確答案：ABD第19題填空題(3分)Ifepithelialcellspopulatefirst,theyrapidlyestablishcoverageoftheexposedrootsurface,forminga____.正確答案：:["longjunctionalepithelium"]第20題單選題(3.5分)Ifgingivalconnectivetissuecellsrepopulatetherootsurfaceafterperiodontalsurgeryfirst,().AnewcementummayformBrootsurfaceankylosismayoccurCnewconnectivetissueattachmentmayformDrootresorptionmayoccur第21題多選題(3.5分)Forasuccessfuloutcomeinperiodontalboneregeneration()mustbeconsidered.AtheremovalofthejunctionalandpocketepitheliumBthepreventionofepithelialcellmigrationintothehealingareaCclotstabilizationDspacecreation正確答案：ABCD第22題多選題(3.5分)GTRconsistsofplacingdifferenttypeofmembraneasthebarriertocover().AtheboneBthegingivalepitheliumCtheperiodontalligamentDthegingivalconnectivetissue正確答案：AC第23題多選題(3.5分)Membranederivedfrom()belongstoresorbablemembrane.AcollagentypeIBpolylacticacid(PLA)Cpolyglycolicacid(PGA)De-PTFE正確答案：ABC第24題判斷題(3分)Highspeedcentrifugationwastophaseseparatethelayersbetweentheredcorpusclebaseandtheoverlayingclearliquidcontainingplasma.第25題多選題(3.5分)Cellsthataretrappedwithinthethree-dimensionalfibrinmatrixinclude().AplateletsBleukocytesCmacrophagesDgranulocytes正確答案：ABCD第26題多選題(3.5分)PRFservesimportantcriteriafortissueregenerationincluding().Aservingasathree-dimensionalfibrinscaffoldBservingasareservoirofnaturalgrowthfactorsCcontainingautologouscellssuchasleukocytes,macrophages,neutrophils,andplateletsDreleasinggrowthfactorsovera1to3-dayperiod.正確答案：ABC第27題填空題(3分)ModificationofthepreparationprotocolofPRFbyreducingtheappliedRCFto208gresultedin____.正確答案：:["theadvancedsolidPRF(A-PRF)"]第28題多選題(3.5分)Asuitablescaffoldshouldpossess().Aa3DandhighlyporousinterconnectedporenetworkBsurfacepropertiesareoptimizedforcellattachmentanddifferentiationCenableflowtransportofnutrientsDonsetofdegradationoccurswiththetissueregeneration正確答案：ABC第29題多選題(3.5分)Syntheticscaffoldsare().Aβ-tricalciumphosphateBpolyglycolicacidCchitosanDpolycarpolactone正確答案：ABD第30題多選題(3.5分)Multiphasicscaffoldsareexpectedtoperformvariousfunctionsincluding().AsupportingcellcolonizationBprovidingsufficientinitialmechanicalstrengthCincreasingcellmigration,growth,anddifferentiationDimpartingbiomimeticfunctionalitytotissue-engineeredboneandsofttissuegrafts正確答案：ABCD課后作業(yè)第1題單選題(4分)Thetoothanditssurroundingattachmenttissues–（）,theperiodontalligamentandthebundlebone–establishafunctionalunit.AtherootcementumBtherootCthecrownDtheenamal第2題判斷題(4分)itiswelldocumentedthatfollowingmultipletoothextractionsandthesubsequentrestorationwithremovabledentures,thesizeofthealveolarridgewillbecomemarkedlyregenerated,notonlyinthehorizontalbutalsointheverticaldimension.第3題單選題(4分)followingtheremovalofsingleteeth,the（）partofthealveolarridgewillbemarkedlydiminished.AmesialBbuccalsideClingualsideD

palatalside第4題判斷題(4分)Resorptionappearstobemorepronouncedatthebuccalthanatlingualorpalatalaspectsoftheridge.第5題判斷題(4分)Class1andclass2ofthebonequalitycharacterizedalocationinwhichthewalls–thecorticalplates–ofthesitearethickandthevolumeofbonemarrowissmall.第6題單選題(4分)class3andclass4ofthebonequalityareborderedbyrelativelythinwallsof()bone.AmarrowBcorticalandmarrowCcorticalDwhole第7題判斷題(4分)thedefinitionofosseointegrationwas“aindirectfunctionalandstructuralconnectionbetweenlivingboneandthesurfaceofaloadcarryingimplant”.第8題單選題(4分)Formationsofnewlyformedbonecouldberecognizedalreadyduringthefirstweekofhealing;thenewlyformedwovenboneprojectedfromthelateralwallofthecutbonybedbutdenovoformationofnewbonecouldalsobeseenontheimplantsurface，thisissocalled（）.AosteogenesisBboneremodelingCboneregenerationDcontactosteogenesis第9題單選題(4分)Theradiographicexaminationwillprovidemoredetailedinformationonthe()and()oftheboneavailableattherecipientsite.AqualityBamountCqualityandamountDnoneistrue第10題判斷題(4分)Ifpossibleanimplantshouldbeplacedintoothposition,bothinamesio-distalandinabucco-lingualdirection.第11題單選題(4分)thestartingpointfortheinsertionoftheimplantinthebonemustbelocatedtowardsthebuccalsideofthecrestinthemandible,andtowardsthe()inthemaxilla.AbuccalBpalateCmesialDitdoesnotmatter第12題單選題(4分)Incasesofpartialedentulism,therecipientsiteclosesttoatoothmustfirstbeidentified.Thecylindrical

canalintherecipientsiteispreparedapproximately()awayfromtheprominenceofthetooth.A3.5–4mmB1-1.5mmC3-3.5mmD2-2.5mm第13題判斷題(4分)theimplantsshouldbeplacedinatripodpositioninsteadofbeinginsertedinastraightline,therebyminimizingthetransmissionofbendingforcesontoeachindividualimplant第14題判斷題(4分)Ifpossibletheimplantsshouldbeplacedintoothposition.Thismeansthatinthenormalcasethelongaxisoftheimplantshouldbedirectedthroughtheocclusalsurfaceofthefinalrestoration.第15題判斷題(4分)Regardingthebucco-lingualdimension,thelongaxisofmandibularimplantswillmainlybedirectedtowardsthelimbuspartoftheincisorsorthepalatalcuspsoftheteethinthemaxilla.第16題判斷題(4分)Afterthepositionoftheimplanthasbeenidentified,thedirectionorinclinationoftheimplantinthejaw，bucco-lingualandmesio-distal，mustbedetermined.第17題判斷題(4分)Forimplantsplacedinthemaxilla,thecorrespondinginclinationshouldbetowardstheincisaledgesofthefrontalteethorthebuccalcuspsofthepremolarsormolarsofthemandible.第18題判斷題(4分)Ifthestartingpointoftheimplantsitesinthemaxillaislocatedclosetothetopofthecrest,andifaconcavity凹o(jì)nthebuccalsideoftheridgeispresent,thereisariskthatthesurgeonleansthelongaxisoftheimplantstoofarbuccally.第19題判斷題(4分)Inextremelyresorbedmandibles,themostdistalimplantthatisplacedimmediatelyinfrontofthementalforamen,canbetilteddistallyinordertoachieveoptimalspreadingofthesupportingunits.第20題判斷題(4分)Peri-implantdiseasemeansInflammatoryprocessesinthetissuessurroundinganimplant.第21題判斷題(4分)Peri-implantmucositismeansReversibleinflammatoryprocessinthesofttissuessurroundingafunctioningimplant.第22題判斷題(4分)Peri-implantitismeansInflammatoryprocessadditionallycharacterizedbylossofperi-implantbone.第23題判斷題(4分)Themucosasurroundingimplantsandthegingivasurroundingteethhasnofeatureincommon.第24題判斷題(4分)Theclinicalfeaturesofperi-implantmucositisareinmanyrespectssimilartothoseofingingivitisatteethandincludeclassicalsymptomsofinflammation,suchasswellingandredness.第25題單選題(4分)()isagooddiscriminatingindicatorofperi-implantmucositis.ABleedingonprobingBrednessCbonelossDboneregeneration課后作業(yè)第1題判斷題(6分)Generally,theforeignbodyreactionoccursaftertheimplantationofthebiologicallyinertmaterialintothebody,andthefibroustissueisformedonthesurface.第2題判斷題(6分)Bioactivematerialsmustbedegradablematerials第3題單選題(6分)WhichofthefollowingisnotthemainfunctionofGTRbarriermembraneforperiodontaltissuerepairandregeneration:()ABarriersofttissueingrowthBProtectthewoundCAnti-bacterialand