1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEElbasvirCat. No.: HY-15789CAS No.: 1370468-36-2Synonyms: MK-8742分式: CHNO分量: 882.02作靶點(diǎn): HCV; HCV Protease作通路: Anti-infection; Metabolic Enzyme/Protease儲(chǔ)存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)

2、驗(yàn) DMSO : 50 mg/mL (56.69 mM)H2O : 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (2.83 mM); Clear solution2. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% corn oil1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemESolubility: 2.5 mg/mL (2.83 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Elbasvir (MK-8742)丙型肝炎病毒結(jié)構(gòu)蛋5A (H

3、CV NS5A) 抑制劑， 對(duì)基因型1a，1b和2a的 EC50 分別為4，3 和3 nM。IC50 & Target EC50: 4 nM (HCV 1a), 3 nM (HCV 1b), 3 nM (HCV 2a) 1體外研究 Elbasvir shows potent activity against genotype 1a and 1b replicons, with EC90 of 0.006 nM for both the wild-type 1a_H77 and 1b_con1 replicons. Elbasvir inhibits genotype 3 replicons w

4、ith EC90 of 0.12 nM. Elbasvir(0.06 nM, 0.6 nM, and 6 nM) demonstrates dose-dependent suppression of resistant genotype 1a replicons,illustrated by the reductions in colony counts at higher doses 1. Elbasvir is highly potent against HCVreplicons bearing NS5A sequences from GT1a, -1b, -2a(31L), -3a, -

5、4a, -5a, and -6, with EC50s in the low-picomolar range 2.戶使本產(chǎn)品發(fā)表的科研獻(xiàn) Hepatology. 2019 May;69(5):1861-1872. J Gastroenterol. 2019 Jan 25. Sci Rep. 2019 Apr 5;9(1):5722. Hepatol Res. 2019 Jul 1. J Chromatogr B. 2019 Jan.See more customer validations on HYPERLINK / www.MedChemEREFERENCES1. Liu R, et al

6、. Susceptibilities of genotype 1a, 1b, and 3 hepatitis C virus variants to the NS5A inhibitor Elbasvir. Antimicrob AgentsChemother. 2015 Nov;59(11):6922-6929.2. Lahser FC, et al. The Combination of Grazoprevir, a Hepatitis C Virus (HCV) NS3/4A Protease Inhibitor, and Elbasvir, an HCV NS5AInhibitor, Demonstrates a High Genetic Barrier to Resistance in HCV Genotype 1a Replicons. Antimicrob Agents Chemother. 2016 AMcePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.T