1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemE4,4-DimethoxychalconeCat. No.: HY-136064CAS No.: 2373-89-9分式: CHO分量: 268.31作靶點: Autophagy作通路: Autophagy儲存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實驗 DMSO : 250 mg/mL (931.76 mM)* means soluble,

2、but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 3.7270 mL 18.6352 mL 37.2703 mL5 mM 0.7454 mL 3.7270 mL 7.4541 mL10 mM 0.3727 mL 1.8635 mL 3.7270 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。體內(nèi)實驗 請根據(jù)您的實驗動物和給藥式選擇適當?shù)娜芙獍?，配制前請先配制澄的儲備液，再依次添加助溶?為保證實驗結(jié)果的可靠性，體內(nèi)實驗的作液，建議您現(xiàn)現(xiàn)配，當天使；澄的

3、儲備液可以根據(jù)儲存條件，適當保存；以下溶劑前的百分指該溶劑在您配制終溶液中的體積占)：1. 請依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 6.25 mg/mL (23.29 mM); Clear solution2. 請依序添加每種溶劑： 10% DMSO 90% corn oilSolubility: 6.25 mg/mL (23.29 mM); Clear solution1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemEBIOLOGICAL ACTIVITY

4、物活性 4,4-Dimethoxychalcone 可從植物當歸中分離得到，種天然噬 (autophagy) 誘導(dǎo)劑，具有抗衰活性1。IC50 & Target Autophagy 1體內(nèi)研究 The flavonoid 4,4-Dimethoxychalcone acts as an anti-ageing compound with cardioprotective effects in miceand the potential to promote longevity across species 1.4,4-Dimethoxychalcone (100mg/kg; intraperi

5、toneally) efficiently triggered autophagic flux in the heart andliver from wild type (WT) C57BL/6 mice 1.Animal Model: 6-week-old male wild type C57BL/6 or Atg4b-/- mice 1Dosage: 100mg/kgAdministration: Injected intraperitoneally with a singleResult: Triggered autophagic flux in the heart and liver.REFERENCES1. Carmona-Gutierrez D, et al. The flavonoid 4,4-dimethoxychalcone promotes autophagy-dependent longevity across species. NatCommun. 2019 Feb 19;10(1):651.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3