1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemE5-Ethynyl-2-deoxyuridineCat. No.: HY-118411CAS No.: 61135-33-9分式: CHNO分量: 252.22作靶點(diǎn): PROTAC Linker作通路: PROTAC儲(chǔ)存式: 4C, protect from light* In solvent : -80C, 6 months; -20C, 1 month (protect fromlight)溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 125 mg/mL (

2、495.60 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制備儲(chǔ)備液1 mM 3.9648 mL 19.8240 mL 39.6479 mL5 mM 0.7930 mL 3.9648 mL 7.9296 mL10 mM 0.3965 mL 1.9824 mL 3.9648 mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存式和期限。BIOLOGICAL ACTIVITY物活性 5-Ethynyl-2-deoxyuridine種 PROTAC linker，屬于 alkyl chain

3、類?？捎诤铣?PROTAC 分 1。IC50 & Target Alkyl-Chain(批量添加)體外研究 PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase andthe other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system toselectively degrade target proteins 1.

4、1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemEREFERENCES1. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs.EBioMedicine. 2018 Oct;36:553-562McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;Fax: 021-