Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEPropylpyrazoletriolCat.No.:HY-100689CASNo.:263717-53-9Synonyms:PPT分?式:C??H??N?O?分?量:386.44作?靶點(diǎn):EstrogenReceptor/ERR作?通路:Others儲(chǔ)存?式:Powder-20°C3yearsInsolvent-80°C6months-20°C1month溶解性數(shù)據(jù)體外實(shí)驗(yàn)DMSO:≥100mg/mL(258.77mM)*"≥"meanssoluble,butsaturationunknown.MassSolvent1mg5mg10mgConcentration制備儲(chǔ)備液1mM2.5877mL12.9386mL25.8772mL5mM0.5175mL2.5877mL5.1754mL10mM0.2588mL1.2939mL2.5877mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；?旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。儲(chǔ)備液的保存?式和期限：-80°C,6months;-20°C,1month。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)?內(nèi)使?，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)?內(nèi)使?。體內(nèi)實(shí)驗(yàn)請(qǐng)根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥?式選擇適當(dāng)?shù)娜芙?案。以下溶解?案都請(qǐng)先按照InVitro?式配制澄的儲(chǔ)備液，再依次添加助溶劑：(為保證實(shí)驗(yàn)結(jié)果的可靠性，澄的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；體內(nèi)實(shí)驗(yàn)的?作液，建議您現(xiàn)?現(xiàn)配，當(dāng)天使?；以下溶劑前顯?的百分?指該溶劑在您配制終溶液中的體積占?；如在配制過(guò)程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過(guò)加熱和/或超聲的?式助溶)1.請(qǐng)依序添加每種溶劑：10%DMSO>>40%PEG300>>5%Tween-80>>45%saline1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemESolubility:≥10mg/mL(25.88mM);Clearsolution2.請(qǐng)依序添加每種溶劑：10%DMSO>>90%(20%SBE-β-CDinsaline)Solubility:≥2.5mg/mL(6.47mM);Clearsolution3.請(qǐng)依序添加每種溶劑：10%DMSO>>90%cornoilSolubility:≥2.5mg/mL(6.47mM);ClearsolutionBIOLOGICALACTIVITY?物活性Propylpyrazoletriol(PPT)?種選擇性的雌激素受體α(ERα)激動(dòng)劑。Propylpyrazoletriol(PPT)對(duì)ERα的相對(duì)結(jié)合親和?(ERα:49%)雌激素受體β(ERβ:0.12%)的410倍[1]。IC50&TargetERα體外研究TheEC50ofPropylpyrazoletriolfortheERα-dependentresponseis140pMinERα-U2OS-Luccells[1].戶使?本產(chǎn)品發(fā)表的科研?獻(xiàn)?IntJBiolSci.2022;18(5):1961-1973.?CancerLett.2021Feb1;498:54-69.?JClinEndocrinolMetab.2021Feb1;dgab020.?JAgricFoodChem.2021Nov24.?MolNeurobiol.2022Sep2.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].InfluenceofcellularERalpha/ERbetaratioontheERalpha-agonistinducedproliferationofhumanT47Dbreastcancercells.[2].StaufferSR,etal.Pyrazoleligands:structure-affinity/activityrelationshipsandestrogenreceptor-alpha-selectiveagonists.JMedChem.2000Dec28;43(26):4934-47.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel