Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemE(S)-MCPGCat.No.:HY-100406CASNo.:150145-89-4Synonyms:(+)-MCPG分?式:C??H??NO?分?量:209.2作?靶點:mGluR作?通路:GPCR/GProtein;NeuronalSignaling儲存?式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性數(shù)據(jù)體外實驗DMSO:1mg/mL(4.78mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制備儲備液1mM4.7801mL23.9006mL47.8011mL5mM---------10mM---------請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；?旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。儲備液的保存?式和期限：-80°C,6months;-20°C,1month。-80°C儲存時，請在6個?內(nèi)使?，-20°C儲存時，請在1個?內(nèi)使?。BIOLOGICALACTIVITY?物活性(S)-MCPG((+)-MCPG)?種有效的I/II類代謝型?氨酸受體(mGluRs)拮抗劑，(RS)-MCPG(HY-100371)的活性異構(gòu)體。(S)-MCPG可?于mGluRs在空間學(xué)習(xí)中的作?研究。IC50&TargetmGluR1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemE體外研究(S)-MCPG(100μM)hasnodetectableeffectsonbasalspineformationoreliminationmechanismsinWTslicecultures.(S)-MCPGpreventstheincreaseinspineturnovertriggeredbyTBSandinterfereswiththemechanismsofactivity-dependentspinestabilizationinHippocampalslicecultures[1].體內(nèi)研究MCPG(intraventricularinjection;20μg)treatedratareslowertolearnthetaskandtakeslongertoreachtheplatformthanvehicleinjectedanimals.Ondays2and3,MCPGratshasasignificantlongerescapelatencyandthemeasureofsearcherrorissignificantlylongeroneachofthefirst3days.Onday4,MCPG-treatedanimalsreachesthesamelevelofperformanceascontrolanimalsinMorriswatermaze[2].AnimalModel:MaleLister-HoodedratsinthelearningoftheMorriswatermaze[2]Dosage:20μgAdministration:Intraventricularinjection;20μg;4daysResult:ImpairedtheperformanceofratsinthespatialversionoftheMorriswatermaze,but1/10ofthisdosedidnot.REFERENCES[1].BernadettBoda,etal.Reversalofactivity-mediatedspinedynamicsandlearningimpairmentinamousemodelofFragileXsyndrome.EurJNeurosci.2014Apr;39(7):1130-7.[2].FBordi,etal.EffectsofthemetabotropicglutamatereceptorantagonistMCPGonspatialandcontext-specificlearning.Neuropharmacology.1996;35(11):1557-65.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonl