Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemESmurf1-IN-A01Cat.No.:HY-110195CASNo.:1007647-73-5Synonyms:A01分?式:C??H??ClF?N?O?S分?量:512.93作?靶點(diǎn):Others作?通路:Others儲(chǔ)存?式:4°C,protectfromlight*Insolvent:-80°C,6months;-20°C,1month(protectfrom

light)溶解性數(shù)據(jù)體外實(shí)驗(yàn)DMSO:62.5mg/mL(121.85mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制備儲(chǔ)備液1mM1.9496mL9.7479mL19.4958mL5mM0.3899mL1.9496mL3.8992mL10mM0.1950mL0.9748mL1.9496mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；?旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。儲(chǔ)備液的保存?式和期限：-80°C,6months;-20°C,1month(protectfromlight)。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)?內(nèi)使?，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)?內(nèi)使?。體內(nèi)實(shí)驗(yàn)請(qǐng)根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥?式選擇適當(dāng)?shù)娜芙?案。以下溶解?案都請(qǐng)先按照InVitro?式配制澄的儲(chǔ)備液，再依次添加助溶劑：(為保證實(shí)驗(yàn)結(jié)果的可靠性，澄的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；體內(nèi)實(shí)驗(yàn)的?作液，建議您現(xiàn)?現(xiàn)配，當(dāng)天使?；以下溶劑前顯?的百分?指該溶劑在您配制終溶液中的體積占?；如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的?式助溶)1.請(qǐng)依序添加每種溶劑：10%DMSO>>40%PEG300>>5%Tween-80>>45%salineSolubility:≥2.08mg/mL(4.06mM);Clearsolution1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemE2.請(qǐng)依序添加每種溶劑：10%DMSO>>90%cornoilSolubility:≥2.08mg/mL(4.06mM);ClearsolutionBIOLOGICALACTIVITY?物活性Smurf1-IN-A01(A01)?種泛素連接酶Smad泛素化調(diào)節(jié)因?-1(Smurf1)抑制劑，kd值為3.664nM，Smurf1-IN-A01通過抑制Smurf1介導(dǎo)的Smad1/5降解來(lái)提?BMP-2的反應(yīng)性[1]。IC50&TargetKd:3.664nM(Smurf1)[1]戶使?本產(chǎn)品發(fā)表的科研?獻(xiàn)?BloodAdv.2021Sep24;bloodadvances.2021004572.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].CaoY,etal.SelectivesmallmoleculecompoundsincreaseBMP-2responsivenessbyinhibitingSmurf1-mediatedSmad1/5degradation.SciRep.2014May14;4:4965.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-589