Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemERomidepsin(GMP)Cat.No.:HY-15149GSynonyms:FK228(GMP);FR901228(GMP);NSC630176(GMP)分?式:C??H??N?O?S?分?量:540.7作?靶點:HDAC;Apoptosis作?通路:CellCycle/DNADamage;Epigenetics;Apoptosis儲存?式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY?物活性Romidepsin(GMP)(FK228(GMP))GMP級別的Romidepsin(HY-15149)。GMP級別的?分?可?做細胞療法中的輔助試劑。Romidepsin(FK228)具有抗腫瘤活性的組蛋?去??；?HDAC)抑制劑，抑制HDAC1，HDAC2，HDAC4和HDAC6，IC50值分別為36nM，47nM，510nM和1.4μM。Romidepsin(FK228)由紫?桿產(chǎn)?，誘導(dǎo)G2/M細胞周期阻滯和凋亡(apoptosis)。體外研究Romidepsin(GMP)(0-72hours;0-80nM)inhibitsproliferationofHCCcellsindose-dependentmanner[2].Romidepsin(GMP)(0-48hours;0-60nM)leadstoatime-anddose-dependentinductionofcellcyclearrestintheG2/MphaseinHCCcells[2].Romidepsin(GMP)(0-48hours;0-60nM)promotesapoptosisinHCCcells,increasesc-caspase-3,c-caspase-9,andc-PARPproteinexpression[2].CellProliferationAssay[2]CellLine:HCCcellsConcentration:0nM;10nM;20nM;30nM;40nM;50nM;60nM;70nM;80nMIncubationTime:0hours;12hours;24hours;48hours;72hoursResult:InhibitedHCCcellsproliferation.CellCycleAnalysis[2]CellLine:HCCcellsConcentration:0nM;15nM;30nM;60nM1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemEIncubationTime:12hours;24hours;48hoursResult:CausedaG2/Marrest.WesternBlotAnalysis[2]CellLine:HCCcellsConcentration:0nM;15nM;30nM;60nMIncubationTime:12hours;24hours;48hoursResult:Increaesdc-caspase-3,c-caspase-9,andc-PARPexpressioninHCCcells.體內(nèi)研究Romidepsin(GMP)(intraperitonealinjection;0.5and1mg/kg;every3day;21days)inhibitedthetumorgrowth,revealsahigherexpressionofp-cdc25C,ki67,c-caspase-3andc-PARP,andalowerexpressionofKi-67inRomidepsintreatedtumors[2].AnimalModel:NudemicewithHuh7cells[2]Dosage:0.5and1mg/kgAdministration:Intraperitonealinjection;0.5and1mg/kg;every3day;21daysResult:Suppressedtumorgrowthinmousexenograftmodels.戶使?本產(chǎn)品發(fā)表的科研?獻?CancerCell.2023Mar13;41(3):602-619.e11.?CancerDiscov.2025Jun16.?CancerRes.2020Oct15;80(20):4426-4438.?CancerRes.2016Dec1;76(23):7001-7011.?JClinInvest.2025Jun2;135(11):e187490.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].FurumaiR,etal.FK228(depsipeptide)asanaturalprodrugthatinhibitsclassIhistonedeacetylases.CancerRes.2002Sep1;62(17):4916-21.[2].SunWJ,etal.RomidepsininducesG2/MphasearrestviaErk/cdc25C/cdc2/cyclinBpathwayandapoptosisinductionthroughJNK/c-Jun/caspase3pathwayinhepatocellularcarcinomacells.BiochemPharmacol.2017Mar1;127:90-100.McePdfHeight2/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemECaution:Producthasnotbeenfullyvalidatedformedica