1、.,細(xì)環(huán)病毒：從實(shí)驗(yàn)室到臨床,Torquetenovirus:thehumanviromefrombenchtobedside,文獻(xiàn)匯報(bào),D.Focosietal.ClinicalMicrobiologyandInfection22(2016)589-593,.,TTV:TransfusiontransmittedvirusorTorquetenovirusFromtorquesandtenuis,Latinfornecklaceandthin,respectively輸血后肝炎（肝中病毒載量是血中的10-100倍，并且與血清ALT升高相關(guān)）【現(xiàn)已否定該結(jié)論】,Humanvirome,atle

2、ast29majorspecies,細(xì)環(huán)病毒：首個(gè)被發(fā)現(xiàn)的單鏈環(huán)狀DNA病毒,.,TTVprevalence95%inmostcasesindependentofage,socioeconomicstandingandhealthconditions來源：胎盤、呼吸道、輸血分布：T淋巴細(xì)胞現(xiàn)有臨床應(yīng)用：TTVasaMarkerofAnthropicPollutionTTVasaMarkerofImmuneStatus,Orphanvirus孤兒病毒（非病原性病毒）,.,檢測(cè)水源是否被污染：現(xiàn)有方法為檢測(cè)細(xì)菌，但是很容易出現(xiàn)假陽(yáng)性某些情況下即使細(xì)菌檢測(cè)為陰性也不能排除被污染檢測(cè)病毒更準(zhǔn)確TTV分

3、布廣泛：醫(yī)院空氣、物件表面均可存在,TTVasaMarkerofAnthropicPollution,TTVasaMarkerofImmuneStatus,免疫功能完整性：theabilitytomountaprotectiveimmuneresponseagainstanantigenicstimulation.現(xiàn)有檢測(cè)：抗原特異性，抗原非特異性；檢測(cè)繁瑣，檢測(cè)方法缺乏標(biāo)準(zhǔn)化TTV與CD8+57+T淋巴細(xì)胞比例成負(fù)相關(guān)對(duì)抗病毒藥不敏感,.,TTVasaMarkerofImmuneStatus,excessive(toomanyopportunisticinfectionsandcancers

4、),inadequate(toomanyepisodesofcellularacuterejection),Maintenanceimmunosuppression,.,WhyIsTTVNotYetPartofaDiagnosticToolKit?,現(xiàn)有研究不足無法培養(yǎng)無抗體檢測(cè)試劑無動(dòng)物模型PCR方法缺乏標(biāo)準(zhǔn)化（引物設(shè)計(jì)）特異性引物非特異性引物,.,TakehomemessagesTTVisatypeofOrphanvirus,prevalence95%inmostcasesTTVreplicatesmainlyinTlymphocytesInsensitivetocurrentantiviraldrugsTTVasaMarkerofImmune