1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEL 888607 RacemateCat. No.: HY-111271ACAS No.: 1030017-51-6分式: CHClFNOS分量: 375.84作靶點(diǎn): Prostaglandin Receptor作通路: GPCR/G Protein儲(chǔ)存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 6 mg/mL (15.96

2、mM; Need ultrasonic)H2O : 40% PEG300 5% Tween-80 45% salineSolubility: 0.6 mg/mL (1.60 mM); Clear solution2. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 0.6 mg/mL (1.60 mM); Clear solution3. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% corn oil1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemESolubility: 0.

3、6 mg/mL (1.60 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 L 888607 Racemate是選擇性前列腺素 D2 受體亞型 1 (DP1) 的拮抗劑，其對(duì) DP1 和 TP 的 Ki 值分別為 132 nM和 17 nM。IC50 & Target DP/DP1 TP132 nM (Ki) 17 nM (Ki)體外研究 L 888607 Racemate (compound 3) maintains a modest binding affinity for the DP1 receptor (Ki = 132 nM)and is act

4、ually 8-fold more potent on the TP receptor (Ki = 17 nM) 1.REFERENCES1. Beaulieu C, et al. Identification of prostaglandin D2 receptor antagonists based on a tetrahydropyridoindole scaffold. Bioorg Med ChemLett. 2008 Apr 15;18(8):2696-700.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;Fax: 021