1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEFG-2216Cat. No.: HY-15641CAS No.: 223387-75-5Synonyms: YM-311分式: CHClNO分量: 280.66作靶點: HIF/HIF Prolyl-Hydroxylase作通路: Metabolic Enzyme/Protease儲存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實驗 DMSO :

2、 31 mg/mL (110.45 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 3.5630 mL 17.8151 mL 35.6303 mL5 mM 0.7126 mL 3.5630 mL 7.1261 mL10 mM 0.3563 mL 1.7815 mL 3.5630 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。BIOLOGICAL ACTIVITY物活性 FG-2216是HIF-PHD抑制劑，IC

3、50值為3.9uM。REFERENCES1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemE1. Hong YR, et al. (4-Hydroxyl-benzo4,5thieno3,2-cpyridine-3-carbonyl)-amino-acetic acid derivatives; HIF prolyl 4-hydroxylaseinhibitors as oral erythropoietin secretagogues. Bioorg Med Chem Lett. 2013 Nov 1;23(21):5953-7.2. Hsieh

4、MM, et al. HIF prolyl hydroxylase inhibition results in endogenous erythropoietin induction, erythrocytosis, and modest fetalhemoglobin expression in rhesus macaques. Blood. 2007 Sep 15;110(6):2140-7.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;Fax: 021-5