1、抗氧化劑：讓你延年益壽Antioxidants: add life to your years NuSkin presentationTaiwanNovember 3, 2007Prof. Lester Packer1 百歲人瑞Centenarian2020406080100020406080100120長壽人口增加後之存活率% Survival if % reduction in mortality at all ages occurs again 1985存活率1985 Survival1900存活率1900 Survival存活率% OF POPULATION SURVIVING 年齡分

2、布 Chronological Age健康長壽的趨勢Toward Healthy AgingT.B.L. Kirkwood in Longevity: To the limits and Beyond. Ed. By J.M. Robine et.al.Published by Springer: Heidelberg, 1997.3020406080100Colon CancerStrokeCoronaryDiseaseDiabetes Type 2 改變生活型態(tài)以預(yù)防疾病的發(fā)生Diseases Avoidable by a Change in LifestyleWalter Willett

3、 Science 296, 695-698: 2002-減少百分比 Percent avoidable結(jié)腸癌中風(fēng)冠狀動(dòng)脈疾病第二型糖尿病4前列腺癌比例上海人Shanghai born Chinese1.7中國人(居住美國 5 年) China born Chinese (live in US 5 年)China born Chinese (live in US 5 yrs)23在美國出生的中國人 US born Chinese37美國出生的高加索人US born Caucasian58USChina亞洲國家AsianCountries西方國家WesternCountriesInt.J. Can

4、cer (2000) 85:60-7Courtesy Emily Ho5氧化壓力 Oxidative Stress自由基造成氧化壓力Free radicals cause oxidative stress導(dǎo)致組織壞死、老化及疾病的發(fā)生Leads to tissue damage, aging and disease6維生素C及E Vitamins C and E多酚類(類黃酮) Polyphenols (Flavonoids)硫氫基Thiols：麩胱甘肽 Glutathione,硫辛酸Lipoic Acid 輔酵素Q10 Co-enzyme Q抗氧化劑 Antioxidants類胡蘿蔔素 Ca

5、rotenoids氧化還原循環(huán) Redox cycling清除自由基 Radical scavenging789皮膚構(gòu)造角質(zhì)層表皮層真皮層10紅斑一種典型的曬傷後發(fā)炎反應(yīng) MED是紅斑的衡量單位。它是指少量的UVB照射24小時(shí)候後，在皮膚產(chǎn)生些微的紅斑現(xiàn)象的評估。1112人體角質(zhì)層中的維生素E濃度-生育醇-生育醇濃度 (pmol)濃度 (pmol)13抗氧化網(wǎng)絡(luò)運(yùn)作模式The Antioxidant Network in MembranesVitE循環(huán)Vit. ECycleQ10循環(huán)Q10 H Cycle維生素C循環(huán)Vit. CCycle脂質(zhì)自由基 Lipid Free Radicals LO

6、O LO類胡蘿蔔素Carotenoids代謝 Metabolism脂溶性環(huán)境Fat Soluble水溶性環(huán)境Water Soluble水溶性環(huán)境Water Soluble氧化代謝OxygenMetabolism14蔬果中的類胡蘿蔔素Carotenoids in fruits & vegetables-隱黃質(zhì)-cryptoxanthin (13-20%)葉黃素Lutein (10-20%)-胡蘿蔔素 a-carotene (5-10%)-胡蘿蔔素 b carotene (15-30%)玉米黃質(zhì) Zeaxanthin (1-5%)菠菜,豌豆,青豆,白豆,綠花菜,球芽甘藍(lán),包心菜,無頭甘藍(lán)菜,奇異果

7、,萵苣 Spinach, Green peas, Green Beans , Lima Beans Broccoli, Brussel sprouts, Cabbage, kale, Kiwi, Lettuce 胡蘿蔔,南瓜,地瓜,杏子,洋香瓜,西瓜Carrots, Pumpkin, Sweet Potatoes,Apricots, Cantaloupe, Watermelon蕃茄,紅葡萄柚 Tomatoes, Pink Grapefruit人類細(xì)胞中的類胡蘿蔔素Carotenoids in Human Plasma蕃茄紅素Lycopene (20-40%)15拉曼光譜研究利用測量眼睛類胡蘿蔔

8、素含量，來診斷老化引起的視網(wǎng)膜黃斑退化現(xiàn)象Raman scattering studies are used to measure carotenoids in the Eye and to diagnose age-related macular degeneration斑點(diǎn)Macula葉黃素&玉米黃質(zhì)Lutein & ZeoxanthinGellermann W, Ermakov IV, McClane RW, Bernstein PS. Raman imaging of human macular pigments. Optics Letters. 2002;27:833 人類視網(wǎng)膜視網(wǎng)

9、膜視神經(jīng)16C. Smidt and D.S. Burke, Nutritional Significance and Measurement of Carotenoids, Current Topics in Nutraceutical Research 2004, 2, 79-91 020000400006000000.511.522.533.54血清中類胡蘿蔔素總量 Total Serum Carotenoids (g/ml)Skin Raman Intensity (n = 372)r = 0.84 (p0.0001)p0.01p0.01p0.01Std. Error 44Std. E

10、rror 38Std. Error 61Std. Error 106247932663929704315071000015000200002500030000350001 or less2 to 34 to 56 or moreCourtesy Stephen Poole, PharmanexSkin Raman Intensity(2005 US data of 209,628 Non-Supplement Users) 每日食用水果及蔬菜份數(shù)Daily servings of fruits and vegetables良好的生活型態(tài)增進(jìn)皮膚抗氧化類胡蘿蔔素與掃描儀之研究 Lifestyle

11、 can improve carotenoid antioxidants in skin- Scanner studies 209,628位受試者從未使用過營養(yǎng)補(bǔ)充品結(jié)論：每日吃6份以上蔬果者，皮膚類胡蘿蔔素指數(shù)明顯增加身體防禦指數(shù)身體防禦指數(shù)174毫克葉黃素4 mg Lutein 杯烹煮過的菠菜 cup of cooked spinach1又1/3根中型胡蘿蔔 或 杯南瓜1 & 1/3 medium carrots or cup pumpkin4毫克 b-胡蘿蔔素 4 mg b-Carotene4毫克蕃茄紅素 4 mg Lycopene1顆中型番茄 或 茶匙番茄醬1 medium tomat

12、oor Tsp tomato paste營養(yǎng)補(bǔ)充品中的類胡蘿蔔素含量與天然食物的相對份量Carotenoids in human supplements equivalent to amounts in food (courtesy KJ Yuem)18食用營養(yǎng)補(bǔ)充品後，血漿中總類胡蘿蔔素濃度增加Plasma Total Carotenoid ConcentrationIs increased after Supplementation時(shí)間,日 Time, DayD1D15D29D43D57Plasma Total Carotenoid (mg/dL)020406080100120140160

13、180Placebo 對照組Mixed Car 綜合類胡蘿蔔素Lutein 葉黃素 b-Carotene b-胡蘿蔔素 Lycopene 蕃茄紅素 * *Significantly different from baseline 顯著差異 * p0.05Courtesy KJ Yuem, et al.血漿中總類胡蘿蔔素濃度(mg/dL)19食用含類胡蘿蔔素的營養(yǎng)補(bǔ)充品在慧星分析法証實(shí)，可以保護(hù)人類淋巴球中的DNA免受破壞Carotenoid Supplementation protects against DNA Damage in human lymphocytesThe comet ass

14、ay第57天 Day 57第1天 Day 135,563位受試者(Subject # 35563)Courtesy KJ Yuem, et al.20維生素A在健康百歲人瑞體內(nèi)含量顯著比年輕人高Vitamin A levels are increased in healthy centenarians compared to younger subjectsVitamin A (M) 100歲Centenarians 60 歲60-79歲80-99 歲153位義大利百歲人瑞153 Italian centenarians, * p 0.0001*0123456Christina Polidori, Eur J Clin Nutr 2007 (M)維生素A21酵素 & 蛋白質(zhì)的誘導(dǎo)物保護(hù)抗氧化劑 Induc