1、 HYPERLINK https:/www.MedChemE/Targets/epoxide-hydrolase.html Epoxide HYPERLINK https:/www.MedChemE/Targets/epoxide-hydrolase.html HYPERLINK https:/www.MedChemE/Targets/epoxide-hydrolase.html HydrolaseEpoxide hydrolases (EH) present in all living organisms. The mammalian soluble epoxide hydrolase (s

2、EH) is a 120 kDa dimer of twoidentical 62.5 kDa monomers arranged in an anti-parallel fashion. It is mostly expressed in the liver, kidneys, brain, endothelium,and at lesser levels in other tissues. Inflammation and pain are major components of many disease states. Mammalian sEHinhibition reduces bl

3、ood pressure, inflammation and pain. The anti-inflammatory activities of sEH inhibitors occur in part throughthe NF-B mediated down-regulation of COX2 transcription, resulting in lower production of pro-inflammatory prostaglandins suchas PGE2 and PGD2.www.MedChemE 1 HYPERLINK https:/www.MedChemE/Tar

4、gets/epoxide-hydrolase.html Epoxide HYPERLINK https:/www.MedChemE/Targets/epoxide-hydrolase.html HYPERLINK https:/www.MedChemE/Targets/epoxide-hydrolase.html Hydrolase HYPERLINK https:/www.MedChemE/Targets/epoxide-hydrolase.html HYPERLINK https:/www.MedChemE/Targets/epoxide-hydrolase.html Inhibitors

5、 HYPERLINK https:/www.MedChemE/rac-ec5026.html (Rac)-EC5026(Rac)-BPN-19186) Cat. No.: HY-135653A HYPERLINK https:/www.MedChemE/1-3-dicyclohexylurea.html 1,3-DicyclohexylureaCat. No.: HY-W013989(Rac)-EC5026 (Rac)-BPN-19186) is a potentpiperidine inhibitor of soluble epoxide hydrolase(sEH) extracted f

6、rom patent WO2019156991A1, page39, has a K of 0.06 nM. (Rac)-EC5026 can be usedfor the research of Parkinsons disease anddementia with Lewy Bodies (DLB).1,3-Dicyclohexylurea (DCU) is an orally active andpotent sEH (soluble epoxide hydrolase) inhibitor.Oral Delivery of 1,3-Dicyclohexylureananosuspens

7、ion enhances exposure and lowers bloodpressure in hypertensive Rats.Purity: 98%Clinical Data: Phase 1Size: 10 mM 1 mL, 5 mg, 10 mg, 25 mg, 50 mg, 100 mgPurity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/1-cyclohexyl-3-dodecyl-urea.html 1-Cyclohexyl-3-dode

8、cyl HYPERLINK https:/www.MedChemE/1-cyclohexyl-3-dodecyl-urea.html HYPERLINK https:/www.MedChemE/1-cyclohexyl-3-dodecyl-urea.html urea(CDU; N-Cyclohexyl-N-dodecyl urea; NCND) Cat. No.: HY-135795 HYPERLINK https:/www.MedChemE/ar-9281.html AR-9281(APAU) Cat. No.: HY-1111511-Cyclohexyl-3-dodecyl urea (

9、CDU;N-Cyclohexyl-N-dodecyl urea; NCND) is a highlyselective soluble epoxide hydrolase (sEH)inhibitor.AR9281 is a potent and selective inhibitor ofsoluble epoxide hydrolase (s-EH), with potentialfor the treatment of hypertension and type 2diabetes.Purity: 98.0%Clinical Data: No Development ReportedSi

10、ze: 10 mM 1 mL, 5 mg, 10 mg, 50 mg, 100 mgPurity: 98.12%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 5 mg HYPERLINK https:/www.MedChemE/arm1.html ARM1(4BSA) Cat. No.: HY-W027340 HYPERLINK https:/www.MedChemE/auda.html AUDACat. No.: HY-108570ARM1 (4BSA) is a potent aminopeptidaseandepoxide

11、 hydrolase inhibitor. ARM1 showsaminopeptidase inhibitory activity with an IC7.61 M and epoxide hydrolase inhibitory activitywith an IC 12.4 M.AUDA (compound 43) is a potent soluble epoxidehydrolase (sEH) inhibitor with IC s of 18 and 69nM for the mouse and human sEH, respectively. AUDAhas anti-infl

12、ammatory activity.Purity: 98%Clinical Data: No Development ReportedSize: 5 mg, 10 mg, 25 mgPurity: 98.0%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 10 mg, 50 mg, 100 mg, 250 mg HYPERLINK https:/www.MedChemE/bi-1935.html BI-1935 HYPERLINK https:/www.MedChemE/bi-1935.html HYPERLINK https:/

13、www.MedChemE/cox-2-seh-in-1.html COX-2/sEH-IN-1Cat. No.: HY-124063 Cat. No.: HY-146704BI-1935 is a potent soluble epoxide hydrolase(sEH) inhibitor for diseases related tocardiovascular disease.COX-2/sEH-IN-1 (Compound 9c) is an orally active,dual COX-2 and sEH (soluble epoxide hydrolase)inhibitor wi

14、th IC values of 1.24 M and 0.40 nMagainst COX-2 and sEH, respectively.COX-2/sEH-IN-1 shows improved anti-inflammatoryactivity and highly reduced cardiovascular risks.Purity: 98.08%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 5 mg, 10 mg, 50 mg, 100 mgPurity: 98%Clinical Data: No Developme

15、nt ReportedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/cuda.html CUDA HYPERLINK https:/www.MedChemE/cuda.html HYPERLINK https:/www.MedChemE/diflapolin.html DiflapolinCat. No.: HY-121538 Cat. No.: HY-128171CUDA is a potent inhibitor of soluble epoxidehydrolase (sEH), with IC s of 11.1 nM and 112 n

16、Mfor mouse sEH and human sEH, respectively. CUDAselectively increases peroxisomeproliferator-activated receptor (PPAR) alphaactivity.Diflapolin is a highly active dual5-lipoxygenase-activating protein (FLAP)/solubleepoxide hydrolase (sEH) inhibitor with markedanti-inflammatory efficacy and high targ

17、etselectivity.Purity: 98.0%Clinical Data: No Development ReportedSize: 5 mg, 10 mg, 25 mg, 50 mg, 100 mgPurity: 99.42%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg2 Tel: 609-228-6898 Fax: 609-228-5909 Email: salesMedChemE HYPERLINK https:/www.MedChemE/dual

18、-faah-seh-in-1.html Dual HYPERLINK https:/www.MedChemE/dual-faah-seh-in-1.html HYPERLINK https:/www.MedChemE/dual-faah-seh-in-1.html FAAH/sEH-IN-1Cat. No.: HY-144738 HYPERLINK https:/www.MedChemE/ec5026.html EC5026(BPN-19186) Cat. No.: HY-135653Dual FAAH/sEH-IN-1 (compound 3) is a high affinitydual

19、sEH (soluble epoxide hydrolase) and FAAH(fatty acid amide hydrolase) inhibitor, with ICvalues of 9.6 and 7 nM, respectively. DualFAAH/sEH-IN-1 shows antinociception against theinflammatory phase.EC5026 (BPN-19186) is a first-in-class, non-opioidand orally active soluble Epoxide Hydrolase (sEH)inhibi

20、tor. EC5026 shows efficacy for inflammatoryand neuropathic pain.Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPurity: 98.01%Clinical Data: Phase 1Size: 10 mM 1 mL, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg HYPERLINK https:/www.MedChemE/GSK2256294A.html GSK2256294A(GSK 2256294) Cat. No.: H

21、Y-19644 HYPERLINK https:/www.MedChemE/seh-inhibitor-1.html sEH HYPERLINK https:/www.MedChemE/seh-inhibitor-1.html HYPERLINK https:/www.MedChemE/seh-inhibitor-1.html inhibitor-1Cat. No.: HY-120494GSK2256294A is a potent, reversible, tight bindinginhibitor of isolated recombinant human sEH(soluble epo

22、xide hydrolase) (IC50 = 27 pM; t1/2 =121 min) and displays potent inhibition againstthe rat (IC50 = 61 pM) and murine (IC50 = 189 pM)orthologs of sEH.sEH inhibitor-1 (compound TCPU ) is a potent andoral active inhibitor of sEH (soluble epoxidehydrolase) with IC s of 0.4 and 5.3 nM in humanand murine

23、, respectively.Purity: 99.53%Clinical Data: Phase 2Size: 10 mM 1 mL, 5 mg, 10 mg, 50 mg, 100 mgPurity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/seh-inhibitor-3.html sEH HYPERLINK https:/www.MedChemE/seh-inhibitor-3.html HYPERLINK https:/www.MedChemE/seh

24、-inhibitor-3.html inhibitor-3 HYPERLINK https:/www.MedChemE/seh-inhibitor-3.html HYPERLINK https:/www.MedChemE/seh-ache-in-4.html sEH/AChE-IN-4Cat. No.: HY-146643 Cat. No.: HY-145833AsEH inhibitor-3 (compound 35) is a potent andorally active soluble epoxide hydrolase (sEH)inhibitor with a K of 0.75

25、nM for human sEH.sEH/AChE-IN-4 (compound (+)-15) is a potent andBBB-penetrated dual inhibitor of sEH (solubleepoxide hydrolase) and AChE(acetylcholinesterase), with IC values of 3.1 nM(hsEH), 1660 nM (hAChE), 179 nM (hBChE, humanbutyrylcholinesterase), 14.5 nM (msEH), and 102Purity: 98%Clinical Data

26、: No Development ReportedSize: 1 mg, 5 mgPurity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/Soluble_epoxide_hydrolase_inhibitors.html Soluble HYPERLINK https:/www.MedChemE/Soluble_epoxide_hydrolase_inhibitors.html HYPERLINK https:/www.MedChemE/Soluble_epo

27、xide_hydrolase_inhibitors.html epoxide HYPERLINK https:/www.MedChemE/Soluble_epoxide_hydrolase_inhibitors.html HYPERLINK https:/www.MedChemE/Soluble_epoxide_hydrolase_inhibitors.html hydrolase HYPERLINK https:/www.MedChemE/Soluble_epoxide_hydrolase_inhibitors.html HYPERLINK https:/www.MedChemE/Solub

28、le_epoxide_hydrolase_inhibitors.html inhibitor HYPERLINK https:/www.MedChemE/Soluble_epoxide_hydrolase_inhibitors.html HYPERLINK https:/www.MedChemE/swe101.html SWE101Cat. No.: HY-U00453 Cat. No.: HY-126326Soluble epoxide hydrolase inhibitor is aninhibitor of soluble epoxide hydrolase, and inhibitsh

29、uman soluble epoxide hydrolase (h-sEH) with pICof 8.4, extracted from patent WO 2010096722 A1,example 57.SWE101 (compound 22 b) is a potent soluble epoxidehydrolase (sEH)-Pinhibitor with IC s of 4 Mand 2.8 M for human and rat sEH-P, respectively.SWE101 does not inhibit neither hydrolase norphosphata

30、se activity of the mouse sEH.Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPurity: 99.83%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg HYPERLINK https:/www.MedChemE/TPPU.html TPPU HYPERLINK https:/www.MedChemE/TPPU.html HYPERLINK https:/www.MedChemE/trans-aucb.html trans-AUCBCat. No.: HY-101294(t-AUCB) Cat. No.: HY-113974TTPU is a soluble epoxide hydrolase (sEH)inhibitor with IC