AMSTARChecklistArticleName:ArticleName:1.DidtheresearchquestionsandinclusioncriteriaforthereviewincludethecomponentsofPICO?ForYes:Optional(recommended)PopulationTimeframeforfollowupInterventionYesNoComparatorgroupOutcomePopulationTimeframeforfollowupInterventionYesNoComparatorgroupOutcomethereviewanddidthereportjustifyanysignificantForYes:Asforpartialyes,plustheprotocolshouldberegisteredandshouldalsohavespecified:reviewquestion(s)ameta-analysis/synthesisplan,ifappropriate,andYesPartialasearchstrategy」IaplanforinvestigatingcausesYesofheterogeneityNoinclusion/exclusioncriteriaaplanforinvestigatingcausesofheterogeneitythereviewanddidthereportjustifyanysignificantForYes:Asforpartialyes,plustheprotocolshouldberegisteredandshouldalsohavespecified:reviewquestion(s)ameta-analysis/synthesisplan,ifappropriate,andYesPartialasearchstrategy」IaplanforinvestigatingcausesYesofheterogeneityNoinclusion/exclusioncriteriaaplanforinvestigatingcausesofheterogeneityariskofbiasassessment3.Didthereviewauthorsexplaintheirselectionofthestudydesignsforinclusioninthereview?ForYes,thereviewshouldsatisfyONEofthefollowing:ExplanationforincludingonlyRCTsYes2.Didthereportofthereviewcontainanexplicitstatementthatthereviewmethodswereestablishedpriortotheconductofdeviationsfromtheprotocol?ForPartialYes:TheauthorsstatethattheyhadwrittenprotocolorguidethatincludedALLthefollowing:

NoORExplanationforincludingonlyNRSINoORExplanationforincludingbothRCTsandNRSI4.Didthereviewauthorsuseacomprehensiveliteraturesearchstrategy?ForPartialYes(allthefollowing):ForYes,shouldalsohave(allthefollowing):」丨searchedatleast2databases」丨searchedthereferencelists/」(relevanttoresearchquestion)bibliographiesofincludedstudies廠YesPartial」1providedkeywordand/orsearch廠 searchedtrial/study ；sstrategyregistriesNo」1justifiedpublication」1included/consultedcontentrestrictions(e.g.language)expertsinthefield」丨whererelevant,searchedforgreyliterature」Iconductedsearchwithin24monthsofcompletionofthereviewDidthereviewauthorsperformstudyselectioninduplicate?ForYes,eitherONEofthefollowing:atleasttworeviewersindependentlyagreedonselectionofeligiblestudiesandachievedconsensusonwhichstudiestoincludeYesNoatleasttworeviewersindependentlyagreedonselectionofeligiblestudiesandachievedconsensusonwhichstudiestoincludeYesNoORtworeviewersselectedasampleofeligiblestudiesandachievedgoodagreement(atleast80percent),withtheremainderselectedbyonereviewer.Didthereviewauthorsperformdataextractioninduplicate?ForYes,eitherONEofthefollowing:atleasttworeviewersachievedconsensusonwhichdatatoextractfromincludedstudiesYesNoatleasttworeviewersachievedconsensusonwhichdatatoextractfromincludedstudiesYesNoORtworeviewersextracteddatafromasampleofeligiblestudiesandachievedgoodagreement(atleast80percent),withtheremainderextractedbyonereviewer.Didthereviewauthorsprovidealistofexcludedstudiesandjustifytheexclusions?ForPartialYes:ForYes,mustalsohave:YesPartialYesPartialNoprovidedalistofallpotentiallyrelevantstudiesthatwerereadinfull-textformbutexcludedfromthereviewJustifiedtheexclusionfromthereviewofeachpotentiallyrelevantstudyDidthereviewauthorsdescribetheincludedstudiesinadequatedetail?shouldalsohaveALLtheForPartialYes(ALLthefollowing):ForYes,shouldalsohaveALLthefollowing:describedpopulationsdescribedpopulationindetaildescribedinterventionsdescribedinterventionindetail(includingdoseswhererelevant)YesYesPartialNodescribedcomparatorsdescribedcomparatorindetaildescribedpopulationsdescribedpopulationindetaildescribedinterventionsdescribedinterventionindetail(includingdoseswhererelevant)YesYesPartialNodescribedcomparatorsdescribedcomparatorindetail(includingdoseswhererelevant)describedoutcomesdescribedstudy'ssettingdescribedresearchdesignstimeframeforfollow-updescribedoutcomesdescribedstudy'ssettingdescribedresearchdesignstimeframeforfollow-upForRoBForRoBfrom:Didthereviewauthorsuseasatisfactorytechniqueforassessingtheriskofbias(RoB)inindividualstudiesthatwereincludedinthereview?RCTsandunconcealedallocation,andlackofblindingofpatientsassessorswhenassessingallocationsequencethatwas」nottrulyrandom,and 廠selectionofthereportedresultfromamongmultipleYesandunconcealedallocation,andlackofblindingofpatientsassessorswhenassessingallocationsequencethatwas」nottrulyrandom,and 廠selectionofthereportedresultfromamongmultipleYesYesPartialNooutcomes(unnecessaryforobjectivemeasurementsoranalysesofaoutcomessuchasall-causespecifiedoutcomemortality)IncludesonlyNRSINRSIForPartialYes,musthaveassessedForYes,mustalsohaveassessedRoB:RoB:fromconfounding,andfromselectionbiasmethodsusedtoascertainexposuresandoutcomes,and」IselectionofthereportedresultfromamongmultiplemeasurementsoranalysesofaspecifiedoutcomeYesYesPartialNoIncludesoutcomes(unnecessaryforobjectivemeasurementsoranalysesofaoutcomessuchasall-causespecifiedoutcomemortality)IncludesonlyNRSINRSIForPartialYes,musthaveassessedForYes,mustalsohaveassessedRoB:RoB:fromconfounding,andfromselectionbiasmethodsusedtoascertainexposuresandoutcomes,and」IselectionofthereportedresultfromamongmultiplemeasurementsoranalysesofaspecifiedoutcomeYesYesPartialNoIncludesonlyRCTsDidthereviewauthorsreportonthesourcesoffundingforthestudiesincludedinthereview?ForYes」IMusthavereportedonthesourcesoffundingforindividualstudies」Yesincludedinthereview.Note:Reportingthatthereviewerslookedforthis廠noinformationbutitwasnotreportedbystudyauthorsalsoqualifiesIfmeta-analysiswasperformeddidthereviewauthorsuseappropriatemethodsforstatisticalcombinationofresults?RCTsForYes:Theauthorsjustifiedcombiningthedatainameta-analysisANDtheyusedanappropriateweightedtechniquetocombinestudyresultsandadjustedforheterogeneityifpresent.YesNoNoANDinvestigatedthecausesofanyheterogeneitymeta-analysisconductedTheauthorsjustifiedcombiningthedatainameta-analysisANDtheyusedanappropriateweightedtechniquetocombinestudyresultsandadjustedforheterogeneityifpresent.YesNoNoANDinvestigatedthecausesofanyheterogeneitymeta-analysisconductedForNRSIForYes:YesNoANDtheyusedanappropriateweightedtechniquetocombinestudyresults,adjustingforheterogeneityifpresentincludedonlylowriskofbiasRCTsYesYesNoANDtheyusedanappropriateweightedtechniquetocombinestudyresults,adjustingforheterogeneityifpresentincludedonlylowriskofbiasRCTsYesTheauthorsjustifiedcombiningthedatainameta-analysisNormeta-analysisANDtheystatisticallycombinedeffectestimatesfromNRSIthatwereconductedadjustedforconfounding,ratherthancombiningrawdata,orjustifiedcombiningrawdatawhenadjustedeffectestimateswerenotavailableANDtheyreportedseparatesummaryestimatesforRCTsandNRSIseparatelywhenbothwereincludedinthereviewIfmeta-analysiswasperformed,didthereviewauthorsassessthepotentialimpactofRoBinindividualstudiesontheresultsofthemeta-analysisorotherevidencesynthesis?ForYes:NoNometa-analysisconductedincludedonlylowriskofbiasRCTsYesNoNometa-analysisconductedincludedonlylowriskofbiasRCTsYesOR,ifthepooledestimatewasbasedonRCTsand/orNRSIatvariableRoB,theauthorsperformedanalysestoinvestigatepossibleimpactofRoBonsummaryestimatesofeffect.DidthereviewauthorsaccountforRoBinindividualstudieswheninterpreting/discussingtheresultsofthereview?ForYes:NoOR,ifRCTswithmoderateorhighRoB,orNRSIwereincludedthereviewprovidedadiscussionofthelikelyimpactofRoBontheresultsDidthereviewauthorsprovideasatisfactoryexplanationfor,anddiscussionof,anyheterogeneityobservedintheresultsofthereview?ForYes:TherewasnosignificantheterogeneityintheresultsYesNo

TherewasnosignificantheterogeneityintheresultsYesNoORifheterogeneitywaspresenttheauthorsperformedaninvestigationofsourcesofanyheterogeneityintheresultsanddiscussedtheimpactofthisontheresultsofthereviewIftheyperformedquantitativesynthesisdidthereviewauthorscarryoutanadequateinvestigationofpublicationbias(smallstudybias)anddiscussitslikelyimpactontheresultsofthereview?ForYes:performedgraphicalorstatistical