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(脂肪酸分解代謝ZhangSchoolofLifeSciences&: :1Mobilizationoffats(TG)fromdietaryintakeandadiposetissuesfattyacidsKetone FAmetabolismregulationand23expendingabout25,000kJ/day3Lipids:insolubilityorlowersolubilityinHighlysolubleinnon-polarTheirwater-insolubilitycontributestomuchofthecomplexitytheirdigestion,transport,and* *polar,moreamphipathiclipidslipidCategories(ChemicalSimplelipid(單純脂質(zhì)--glyceride(甘油酯)wax(蠟--phosphatidate(磷脂)glycolipid(糖脂Derivedlipid(衍生脂質(zhì)sterol(固醇類)terpene(萜5Simplelipid(單純脂質(zhì)Biological--highmelting--energy--water-impermeable(不透水)棕櫚 三十烷Triacontanyl-palmitateisthemajorcomponentofbeeswax. Simplelipid(單純脂質(zhì)Naturaloilsmainlycontaintriacyl-glycerolswithunsaturatedfattyacids--liquidsatroomSolidfatscontainprimarilysaturatedfatty7--highmelting7--solidatroomCellMetab.2015Oct6;22(4):658-IntroductiontofattyacidsFattyacidsplayimportantBuildingblocksforphospholipids(磷脂&proteinstoHighenergysourceofHormonesor9TwosourcesofFA:storedanddietaryFAsrepresenttheprincipalformofstoredenergyin(triacylglycerolstriglycerides甘油三酯brownandwhiteThecarboninfattyacids(-CH2)iscomple yreduced-moreenergyFattyacidsarenothydrated,socanpackmorecloselyinstoragetissuesfattyacidSaturatedFA;unsaturatedFA;polyunsaturatedpalmitic(16:0)、Palmitoleic(棕櫚油酸)(16:1△9)、oleic(18:1△9Linoleic(亞油酸)(18:2△9,12)、α-linolenic(α-亞麻酸)(18:3△9,12,15)、γ-liolenic(γ-亞麻酸)(18:,14)EPA(20碳五烯酸)(20:5△5,8,11,14,17)DHA(22碳六烯酸)SaturatedVs.UnsaturatedPolarheadSaturatedFatty
Fatty1doubleStearicAcidC-硬脂
OleicAcidC-油 FAstructurecarbonnumberismostlythefirsttwinbondofmonounsaturatedFAismostlyinthe9thposition,andthesecond,thirdtwinbondaremostlyinthe12th,15thposition;mostdoublebondiscis,onlyfewistransTriglycerides甘油三酯,TG) 9kcal/gvs4kcal/gforBrownandwhiteActionofThermogenin(UCP1)inbrownfatcellsNature.2012Jan11;481(7382):463- tissuerepairandcellsStoredmetabolicfuelinaFatfromDiet&AdiposeAcquiredreadilyinthedietandc sobemadefromcarbohydratesandthecarbonskeletonsofaminoacidsTGsrepresentthemajorenergyinputinthedietofthemodernwesterncountriesandthecityareaofChinaTGsarethemajorformofstoredenergyinthebodyinspecializedcells,adipocytesMobilizationoffatsfromdietaryintakeandadiposetissuesDegradationofdietaryoccursprimarilyintheMobilizationoffats:fatsEOther Inthestomach,asmallextentbylipasesinlow-pHIntheduodenum,alkalinepancreaticjuiceraisespH,allowinghydrolysisofTGbypancreaticlipaseandbynon-specificesterasesPancreaticlipasereleasesfattyacidsfromC-1andC-3positionofOtherlipasesandnonspecificesterasestheC-2Bilesaltsisafamilyofcarboxylicacidsaltswithsteroidbackbones,actingasdetergentstoemulsifyTGsandfacilitatetheactivityofthelipaseandesterasesdietaryfatdigestion(消化PancreaticLipases(胰脂肪酶Pancreatic
PancreaticDegradationofdietaryPancreaticLipases(胰脂肪酶Absorption(吸收)andShortchainofFAsareabsorbeddirectlyintotheintestinalLongchainFAs(≥12C)combinewithbilesaltsinmixedmicelles,whichdeliverFAstoepithelialcellstoformnewTGs.NatRevGastroenterolHepatol.2015Apr;12(4):205-Absorption(吸收)andInintestinalmucosalcells(腸粘膜細胞),FAandareresynthesizedintoTGsandpackagedintochylomicrons(乳糜微粒MovementofDietaryLipidfromSmallIntestinetoPeripheralTissues膽脂蛋白脂肪酶粘UtilizationofFattyAcidsasThreestagesofTriglycerolsaredegradedtofattyacidsandglycerolintheadiposetissue(脂肪組織)andtransportedtootherFattyacidsareactivatedandtransportedintoFattyacidsarebrokendownintotwo-carbonCoAunitsandfedintothecitricacidBreakdownofIntheadiposetissue(脂肪組織lipasesareactivatedby Thefattyacidsaretransportredinthebloodbyserum Theglycerolisabsorbedbytheliverandconvertedtoglycolyticintermediates.AcylCoAsynthetasereactionoccursonmitochondrialConsumptionof2脂酰輔酶A合成TransportintoMitochondrialMatrixCarnitine肉堿carrieslong-activatedfattyacidsintomitochondrialUssherJR,LopaschukGD,ArduiniA.GutmicrobiotametabolismofL-carnitine FattyacidFranzKnoop’slabelingexperiments(1904)FAsaredegradedbyoxidationattheβcarbonatom.1).oxidationtotrans-?(氧化反式烯酰2).Hydrationto(水合Enoyl-CoA Oxidationto(氧化L-Hydroxyacyl-CoA Thiolysisto(硫解β-硫ATP--16Cpalmitate(棕櫚酸)produces106ATP's【Minusthe2fortheactivation(-2)】Migratorybirdstravellongdistancesonenergyfromfattyacidoxidation Somemigratorybirdsflywithout andbuildbodyfat–Thepercentageofdryweightbodyfatinthesebirdscanbeashigh70%whenmigrationbegins(vs~30%andlessfornon-migratoryFattyacidoxidationisanimportantsourceofmetabolicwaterforsomeanimalsSpecial 內(nèi)容UnsaturatedfattyacidsUnsaturatedfattyacidsKetone ),acetoacetate(乙酰乙酸),and Theformationofketonebodies,synthesizedprimarilyinliverHMG-CoAHMG-CoA乙酰乙酰乙酸脫羧 羥丁酸脫氫β-羥丁訓(xùn)練后2小 訓(xùn)練后12小 FAmetabolismregulationandFAentersintomitochondriaInheart-inhibitbyacetyl-CoAandBodymetabolis
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