精品精品感謝下載載感謝下載載IChooseonewhichisthebestanswerineachquestion (40x1point=40)Immunologicalunresponsivenesstoselfantigensiscalled:(A)AToleranceBTolerogenCMemoryDAcquiredimmunityThesignaltransductionmoleculesassociatedwithBCRare(B)A.CD21andCD81.B.IgandIg0CD79a,bC.IgDandIgM.D.ITAMsandITIMs.TcellsareMHC-restrictedintheirabilitytorespondtoantigenbecause(D)allantigenmustbeprocessedandpresentedtoactivatelymphocytes.duringaninfection,allcellsinthebodypresentantigenonMHCClassI.MHCbindsantigenmorespecificallythanTCRdoes.TCRmustrecognizebothantigenandMHCmolecules.AnantibodyFabcontains(AB)A.complementaritydeterminingregions.B.HandLchainvariableregions.C.oneantigenbindingregion. D.oneH-Linterchaindisulfidebond.Positiveselectioninthethymusismediatedby:(A)AThymicepithelialcells.BMacrophages.CDendriticcells.DB-cells.TypeIVhypersentivityisoftenreferredtoas:ImmediatehypersensitivityDelayedhypersensitivityImmediatehypersensitivityDelayedhypersensitivityCytotoxichypersensitivityAllergichypersensitivityCytotoxichypersensitivityAllergichypersensitivity7.TypeHhypersentivityisoftenreferredtoas:7.TypeHhypersentivityisoftenreferredtoas:ImmediatehypersensitivityDelayedhypersensitivityImmediatehypersensitivityDelayedhypersensitivityCytotoxichypersensitivityAllergichypersensitivityCytotoxichypersensitivityAllergichypersensitivityNaiveBcellexpresses(C)A.IgAaloneB.IgAandIgGCIgM+IgDD.IgEandIgTcell-derivedcytokines(D)areantigen-specificproductsofTcellactivationarestoredintherestingTcellandreleasedonactivationareMHC-restrictedintheireffectsinfluencetheclassofantibodiesproducedbyBcellNeutrophilsareattractedtoaninfectedareaby (C)A.IgMB.C1C.C5aD.C8Complementlysescellsby(C)enzymaticdigestionofthecellmembraneactivationofadenylatecyclaseinsertionofcomplementproteinsintothecellmembraneinhibitionofelongationfactor2CD8isamarkerof(C)A.BcellsB.Helper-TcellsC.cytotoxicTcellD.M小

B.Bcells,DCandM小D.Onlyonvirally-infectedB.Bcells,DCandM小D.Onlyonvirally-infectedA.VirtuallyallcellsinthebodyC.Virtuallyallnucleatedcellsinthebodycells.AlloffollowingcytokinesaresecretedbyTh2cellsexcept (B)A.IL-4B.IFN-TC.IL-5D.IL-6WhichofthefollowingisNOTtrueofCD4+andCD8+cellmarkers?(D)ThesearebothsurfaceglycoproteinsexpressedonT-cells.TheseservetodistinguishdifferenttypesofT-cells,e.g.,helper,suppressorandcytotoxic,fromeachother.Thesearenotfoundassociatedwithimmunoglobulins.BothofthemarkersarepresentonALLT-cells.CellsbearingMHCclassIpluspeptidearetargetsforspecific: (B)AB-cells.BCytotoxicT-cells. CTh1cells.DTh2cells.Dendriticcellsarecharacterizedby: (D)AthepresenceofmajorbasicproteinBexpressionofCD3CexpressionofIgMmolecules DtheirinterfacebetweentheinnateandadaptiveimmunesystemWhichofthefollowinguniquelydistinguishestheT-cellreceptor(TCR)fromanantibody?(A)TheTCRcanbindanantigenfragmentonlyinatrimolecularcomplexwitheithertheclassIorclassIIsurfaceproteinsofthemajorhistocompatibilitycomplexTheTCRcanfunctionasacellsurfaceantigenreceptorTheTCRiscomposedoftwodifferenttypesofpolypeptidechainsTheTCRiscapableofparticipatinginacytotoxicreaction.Acriticalpropertyofanantigenis(A)Itsabilitytostimulateanimmuneresponseauniquetopologicalfeaturecalledanparatopenotauniquetopologicalfeaturecalledanantigenicdeterminantthesizeofwhichisrelativelysmall.Opsonizationofbacteriaoccursthroughcoatingbacteriajustwith:(A)AC3bBC8CMembraneattackcomplex DIgMThefollowingischaracteristicofB-butnotT-cells: (D)AClassIMHC.BCD3.CHIVvirusreceptor.DSurfaceimmunoglobulin.WhichofthefollowingmoleculesisexpressedonthesurfaceofmatureCD4+Tcells?(C)A.BcellreceptorB.CD1dC.CD3D.CD8.Thethymusisthesiteofinitialdifferentiationfor (D)D.TcellsA.BcellsB.ErythrocytesC.HematopieticstemcellsD.TcellsTOC\o"1-5"\h\zThemembraneattackcomplexconsistsof: (C)AOH BC3b3b,Bb CC5b,6,7,8,9 DProperdinTypeIhypersentivityisoftenreferredtoas: (A)A.Immediatehypersensitivity B.DelayedhypersensitivityC.Cytotoxichypersensitivity D.ImmunecomplexhypersensitivityTypemhypersentivityisoftenreferredtoas: (D)A.Immediatehypersensitivity B.DelayedhypersensitivityC.Cytotoxichypersensitivity D.ImmunecomplexhypersensitivityThetypeIhypersentivityismediatedby: (D)A.IgAB.IgDC.IgGD.IgEThecytokinewhichismostinvolvedintheclassswitchtoIgEproductionis:(D)A.IL-1B.IL-2C.TGFbetaD.IL-4WhichtypehypersensitivityisrelatedtothemechanismofacuteArthusreaction: (C)A.TypeIhypersentivity B.TypeHhypersentivityC.Typemhypersentivity D.TypeIVhypersentivityT-cellCD40LprovidesacostimulatorysignaltoB-cellsbyligating:(A)ACD40BMHCclassII CCD28DCD19Whichimmunoglobulincanbetransportedthroughtheplacenta?

A.IgGB.IgMC.SecretoryIgAD.IgEWhichimmunoglobulinisthemostoneintheblood? (A)A.IgGB.IgMC.SecretoryIgAD.IgEWhichimmunoglobulincanmediatetheimmediatehypersensitivity?(D)A.IgGB.IgMC.SecretoryIgAD.IgEDIFN-TDIFN-TAnitricoxideBgranzymeCcomplementImmunecomplexesconsistof (C)A.antibodypluscomplement B.basophilpluscomplementC.antigenplusantibody D.antigenpluscomplementThemaincostimulatorysignalforactivationofrestingT-cellsisprovidedbyligationof:(A)ACD28BSurfaceIgCLFA-1 DVLA-4TheT-cellreceptorantigenrecognitionsignalistransducedby: (E)ATheTCRalphachain.BTheTCRbetachain.DCD2.ECD3.TheT-cellligandbindingB7onaprofessionalantigen-presentingcellis:AACD28BCD2CLFA-1DICAM-1Secondaryantibodyresponsesarebetterbecause:( C)ATheyprovidedefenseagainstunrelatedantigensBTheantibodycanbemadebybothTandBcellsCTheyarestrongerandfasterDTheydonotrequireT-cellhelpWhichcelltypeproducesantibodies?: (D)AMacrophages BT-lymphocytes CNKDPlasmacellsII.Indicatewhethereachofthefollowingstatementsistrueorfalse.(10>2points=20 )Ahaptencanstimulateantibodyformationbutcannotcombinewithantibodymolecules.(F)Boostershotsarerequiredbecauserepeatedexposuretoanantigenbuildsastrongerimmuneresponse.(T)TheIgMgBheterodimerandCD3serveanalogousfunctionsintheB-cellreceptorandT-cellreceptor,respectively.(T)Antigen-presentingcellsexpressbothclassIandclassIIMHCmoleculesontheirmembranes.(T)BabiescanacquireIgE-mediatedallergiesbypassivetransferofmaternalantibody.(F)BothCTLsandNKcellsreleaseperforinafterinteractingwithtargetcells.(T)Targetcelllysisanddestructioncanbeachievedbyperforinreleasedfromantigen-specificcytotoxicT-cells(T)Theimmuneresponseismediatedviathehumoraland/orcellulararmsoftheimmunesystem(T)ImmediatetypehypersensitivityismediatedbyIgM. (F)Allcytokine-bindingreceptorscintaintwoorthreesubunits.(T)mAnswerthefollowingquestionsinbrief (10Mpoints=40 )NamethethreetypesofprofessionalAPCs,andgiveoneexampleofnonprofessionalAPCs.BMDCendothelialcellSummarizethefourmajorfunctionsofcomplementsystem ①lysisofcells,bacteriaandviruses②opsonizationtoenhancephagocytosis③clearanceofimmunecomplexes④stimulationofinflammationListtheclassicalClass