Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEBAI1Cat.No.:HY-103269CASNo.:335165-68-9分?式:C??H??Br?N?O分?量:467.2作?靶點(diǎn):Bcl-2Family;Apoptosis作?通路:Apoptosis儲(chǔ)存?式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性數(shù)據(jù)體外實(shí)驗(yàn)DMSO:18.67mg/mL(39.96mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制備儲(chǔ)備液1mM2.1404mL10.7021mL21.4041mL5mM0.4281mL2.1404mL4.2808mL10mM0.2140mL1.0702mL2.1404mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；?旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。儲(chǔ)備液的保存?式和期限：-80°C,6months;-20°C,1month。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)?內(nèi)使?，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)?內(nèi)使?。體內(nèi)實(shí)驗(yàn)請(qǐng)根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥?式選擇適當(dāng)?shù)娜芙?案。以下溶解?案都請(qǐng)先按照InVitro?式配制澄的儲(chǔ)備液，再依次添加助溶劑：(為保證實(shí)驗(yàn)結(jié)果的可靠性，澄的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；體內(nèi)實(shí)驗(yàn)的?作液，建議您現(xiàn)?現(xiàn)配，當(dāng)天使?；以下溶劑前顯?的百分?指該溶劑在您配制終溶液中的體積占?；如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的?式助溶)1.請(qǐng)依序添加每種溶劑：10%DMSO>>40%PEG300>>5%Tween-80>>45%salineSolubility:≥1.87mg/mL(4.00mM);Clearsolution1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemE2.請(qǐng)依序添加每種溶劑：10%DMSO>>90%cornoilSolubility:≥1.87mg/mL(4.00mM);ClearsolutionBIOLOGICALACTIVITY?物活性BAI1?種選擇性的凋亡因?BAX變構(gòu)抑制劑。BAI1結(jié)合BAX并變構(gòu)抑制其激活。BAI1具有潛??于BAX依賴性細(xì)胞死亡介導(dǎo)的疾病的研究[1]。IC50&TargetBax體外研究BAI1selectivelyinhibitsBAX-mediatedapoptoticcelldeath[1].BAI1showsinhibitionoftBID(HY-100464)-inducedBAX-mediatedmembranepermeabilizationinadosedependentmannerwithanIC50of3.3μΜ[1].ApoptosisAnalysis[1]CellLine:MouseMEFConcentration:0.3125μM,0.625μM,1μM,1.25μM,1.5μM,2.5μM,3μM,4μM,54μM,104μMIncubationTime:8hoursResult:InhibitedcelldeathinBAX-dependentmanner.戶使?本產(chǎn)品發(fā)表的科研?獻(xiàn)?UniversityofRijeka.FacultyofMedicine.2021Jun.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].GarnerTP,etal.Small-moleculeallostericinhibitorsofBAX.NatChemBiol.2019Apr;15(4):322-330.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-