Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEDSP-4hydrochlorideCat.No.:HY-103210CASNo.:40616-75-9Synonyms:NeurotoxinDSP4hydrochloride分?式:C??H??BrCl?N分?量:313.06作?靶點:Others作?通路:Others儲存?式:4°C,sealedstorage,awayfrommoisture*Insolvent:-80°C,6months;-20°C,1month(sealed

storage,awayfrommoisture)溶解性數(shù)據(jù)體外實驗DMSO:125mg/mL(399.28mM;Needultrasonic)H2O:50mg/mL(159.71mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制備儲備液1mM3.1943mL15.9714mL31.9428mL5mM0.6389mL3.1943mL6.3886mL10mM0.3194mL1.5971mL3.1943mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；?旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。儲備液的保存?式和期限：-80°C,6months;-20°C,1month(sealedstorage,awayfrommoisture)。-80°C儲存時，請在6個?內(nèi)使?，-20°C儲存時，請在1個?內(nèi)使?。體內(nèi)實驗請根據(jù)您的實驗動物和給藥?式選擇適當(dāng)?shù)娜芙?案。以下溶解?案都請先按照InVitro?式配制澄的儲備液，再依次添加助溶劑：(為保證實驗結(jié)果的可靠性，澄的儲備液可以根據(jù)儲存條件，適當(dāng)保存；體內(nèi)實驗的?作液，建議您現(xiàn)?現(xiàn)配，當(dāng)天使?；以下溶劑前顯?的百分?指該溶劑在您配制終溶液中的體積占?；如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的?式助溶)1.請依序添加每種溶劑：10%DMSO>>40%PEG300>>5%Tween-80>>45%saline1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemESolubility:≥2.08mg/mL(6.64mM);Clearsolution2.請依序添加每種溶劑：10%DMSO>>90%(20%SBE-β-CDinsaline)Solubility:≥2.08mg/mL(6.64mM);Clearsolution3.請依序添加每種溶劑：10%DMSO>>90%cornoilSolubility:≥2.08mg/mL(6.64mM);Clearsolution4.請依序添加每種溶劑：PBSSolubility:50mg/mL(159.71mM);Clearsolution;NeedultrasonicBIOLOGICALACTIVITY?物活性DSP-4hydrochloride?種?度選擇性的腎上腺素能神經(jīng)毒素。DSP-4hydrochloride可以穿過?腦屏障。DSP-4hydrochloride可?于中樞和外周去甲腎上腺素能神經(jīng)元的暫時選擇性降解。體內(nèi)研究DSP-4hydrochloride(i.p.;50mg/kg;single)destroystheLCneuronsandfibers[1].AnimalModel:rats[1]Dosage:50mg/kgAdministration:intraperitoneal,singleResult:NotvisualizedlargeprojectionneuronsandthefibersoftheLC.REFERENCES[1].HormigoS,etal.TheselectiveneurotoxinDSP-4impairsthenoradrenergicprojectionsfromthelocuscoeruleustotheinferiorcolliculusinrats.FrontNeuralCircuits.2012Jun28;6:41.[2].Jaim-EtcheverryG,etal.DSP-4:anovelcompoundwithneurotoxiceffectsonnoradrenergicneuronsofadultanddevelopingrats.BrainRes.1980Apr28;188(2):513-23.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseon