Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEBAY-6035Cat.No.:HY-112080CASNo.:2247890-13-5分?式:C??H??N?O?分?量:396.48作?靶點(diǎn):HistoneMethyltransferase作?通路:Epigenetics儲(chǔ)存?式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性數(shù)據(jù)體外實(shí)驗(yàn)DMSO:100mg/mL(252.22mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制備儲(chǔ)備液1mM2.5222mL12.6110mL25.2220mL5mM0.5044mL2.5222mL5.0444mL10mM0.2522mL1.2611mL2.5222mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；?旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。儲(chǔ)備液的保存?式和期限：-80°C,6months;-20°C,1month。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)?內(nèi)使?，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)?內(nèi)使?。BIOLOGICALACTIVITY?物活性BAY-6035?種有效的，選擇性，底物競(jìng)爭(zhēng)性SMYD3抑制劑。BAY-6035抑制MEKK2的甲化，IC50值為88nM。IC50&TargetSMYD388nM(IC50)1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemE體外研究BAY-6035inhibitsinvitromethylationofMEKK2peptidewithanIC50of88nMandhasmorethan100-foldselectivityoverotherhistonemethyltransferases[1].BAY-6035inhibitsthemethylationofMEKK2incellswithanIC50of70nM[1].REFERENCES[1].EdoardoF,et,al.Small-moleculeinhibitorsoflysinemethyltransferasesSMYD2andSMYD3:currenttrends.FutureMedChem.2019Apr;11(8):901-921.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792ax:021-5370