Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEGuanosine5'-diphosphatedisodiumsaltCat.No.:HY-113066ACASNo.:7415-69-2Synonyms:GDPdisodiumsalt分?式:C??H??N?Na?O??P?分?量:487.16作?靶點:EndogenousMetabolite;PotassiumChannel作?通路:MetabolicEnzyme/Protease;MembraneTransporter/IonChannel儲存?式:-20°C,sealedstorage,awayfrommoisture*Insolvent:-80°C,6months;-20°C,1month(sealed

storage,awayfrommoisture)溶解性數(shù)據(jù)體外實驗H2O:125mg/mL(256.59mM;Needultrasonic)DMSO:<1mg/mL(ultrasonic;warming;heatto80°C)(insolubleorslightlysoluble)MassSolvent1mg5mg10mgConcentration制備儲備液1mM2.0527mL10.2636mL20.5271mL5mM0.4105mL2.0527mL4.1054mL10mM0.2053mL1.0264mL2.0527mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；?旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。儲備液的保存?式和期限：-80°C,6months;-20°C,1month(sealedstorage,awayfrommoisture)。-80°C儲存時，請在6個?內(nèi)使?，-20°C儲存時，請在1個?內(nèi)使?。體內(nèi)實驗請根據(jù)您的實驗動物和給藥?式選擇適當?shù)娜芙?案。以下溶解?案都請先按照InVitro?式配制澄的儲備液，再依次添加助溶劑：(為保證實驗結(jié)果的可靠性，澄的儲備液可以根據(jù)儲存條件，適當保存；體內(nèi)實驗的?作液，建議您現(xiàn)?現(xiàn)配，當天使?；以下溶劑前顯?的百分?指該溶劑在您配制終溶液中的體積占?；如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的?式助溶)1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemE1.請依序添加每種溶劑：PBSSolubility:100mg/mL(205.27mM);Clearsolution;NeedultrasonicBIOLOGICALACTIVITY?物活性Guanosine5'-diphosphate(GDP)disodiumsalt?種核苷?磷酸，可激活5'-三磷酸腺苷敏感的K+通道。Guanosine5'-diphosphatedisodiumsalt?種潛在的鐵動員劑，可阻斷鐵調(diào)素-鐵轉(zhuǎn)運蛋?(hepcidin-ferroportin)相互作?并調(diào)節(jié)IL-6/stat-3通路。Guanosine5'-diphosphatedisodiumsalt可?于炎癥研究，如炎癥性貧?(AI)。IC50&TargetHumanEndogenousMetabolite戶使?本產(chǎn)品發(fā)表的科研?獻?IntJMolSci.2022Oct27;23(21):13058.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].SKajioka,etal.Guanosinediphosphateactivatesanadenosine5'-triphosphate-sensitiveK+channelintherabbitportalvein.JPhysiol.1991Dec;444:397-418.[2].AngmoS,etal.IdentificationofGuanosine5'-diphosphateasPotentialIronMobilizer:PreventingtheHepcidin-FerroportinInteractionandModulatingtheInterleukin-6/Stat-3Pathway.SciRep.2017Jan5;7:40097.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel