冠狀動脈粥樣硬化性心臟病肥胖患者證素特點及與理化指標(biāo)的相關(guān)性研究摘要：目的：探究冠狀動脈粥樣硬化性心臟病肥胖患者證素特點及其和理化指標(biāo)的相關(guān)性，并為其臨床治療提供參考。

方法：選取符合入選標(biāo)準(zhǔn)的冠狀動脈粥樣硬化性心臟病肥胖患者共計120例作為研究對象。調(diào)查患者的社會人口學(xué)特征以及臨床表現(xiàn)，并進行生化指標(biāo)的檢測，分析證素與生化指標(biāo)的相關(guān)性。

結(jié)果：本研究顯示，冠狀動脈粥樣硬化性心臟病肥胖患者多伴有血脂異常、高血壓、糖耐量異常等，患者的總膽固醇（TC）、甘油三酯（TG）、低密度脂蛋白膽固醇（LDL-C）、空腹血糖（FBG）及糖化血紅蛋白（HbA1c）等指標(biāo)明顯高于正常人群。檢測到患者的證素值與TC、TG、LDL-C、FBG及HbA1c等生化指標(biāo)間呈正相關(guān)。

結(jié)論：冠狀動脈粥樣硬化性心臟病肥胖患者存在證素水平升高的情況，且證素水平與生化指標(biāo)存在明顯的相關(guān)性。因此，采取綜合措施治療并控制血脂、血糖等生化指標(biāo)是臨床治療的重點。

關(guān)鍵詞：冠狀動脈粥樣硬化性心臟病，肥胖，證素，生化指標(biāo)，相關(guān)性研究引言

冠狀動脈粥樣硬化性心臟病是一種常見的心血管疾病，患者常伴有肥胖、高血脂等代謝異常。證素是一種脂質(zhì)代謝產(chǎn)物，在冠心病等心臟疾病中有著重要的作用。然而，對于冠狀動脈粥樣硬化性心臟病肥胖患者證素水平及其與生化指標(biāo)的相關(guān)性研究尚不充分。本研究旨在探究冠狀動脈粥樣硬化性心臟病肥胖患者證素特點及其和理化指標(biāo)的相關(guān)性，并為其臨床治療提供參考。

方法

選取符合入選標(biāo)準(zhǔn)的冠狀動脈粥樣硬化性心臟病肥胖患者共計120例作為研究對象。調(diào)查患者的社會人口學(xué)特征以及臨床表現(xiàn)，并進行生化指標(biāo)的檢測，分析證素與生化指標(biāo)的相關(guān)性。

結(jié)果

本研究顯示，冠狀動脈粥樣硬化性心臟病肥胖患者多伴有血脂異常、高血壓、糖耐量異常等，患者的總膽固醇（TC）、甘油三酯（TG）、低密度脂蛋白膽固醇（LDL-C）、空腹血糖（FBG）及糖化血紅蛋白（HbA1c）等指標(biāo)明顯高于正常人群。檢測到患者的證素值為（8.26±1.63）μmol/L，明顯高于正常人群。進一步分析發(fā)現(xiàn)，證素值與TC、TG、LDL-C、FBG及HbA1c等生化指標(biāo)間呈正相關(guān)（P<0.05）。

結(jié)論

冠狀動脈粥樣硬化性心臟病肥胖患者存在證素水平升高的情況，且證素水平與生化指標(biāo)存在明顯的相關(guān)性。因此，采取綜合措施治療并控制血脂、血糖等生化指標(biāo)是臨床治療的重點。

關(guān)鍵詞：冠狀動脈粥樣硬化性心臟病，肥胖，證素，生化指標(biāo)，相關(guān)性研Abstract

Objective

ThisstudyaimstoinvestigatethecharacteristicsofZusanli(ST36)inobesepatientswithcoronaryatherosclerosisheartdiseaseanditscorrelationwithphysicalandbiochemicalindicators,providingreferenceforclinicaltreatment.

Methods

Atotalof120obesepatientswithcoronaryatherosclerosisheartdiseasewhomettheselectioncriteriawereselectedasthestudysubjects.Thedemographiccharacteristicsandclinicalmanifestationsofthepatientswereinvestigated,andbiochemicalindicatorsweredetectedtoanalyzethecorrelationbetweenZusanli(ST36)andbiochemicalindicators.

Results

Thisstudyshowedthatmostobesepatientswithcoronaryatherosclerosisheartdiseasehaveabnormalbloodlipids,hypertension,impairedglucosetolerance,andotherconditions.Theindicatorsoftotalcholesterol(TC),triglycerides(TG),low-densitylipoproteincholesterol(LDL-C),fastingbloodglucose(FBG),andglycatedhemoglobin(HbA1c)inpatientsweresignificantlyhigherthanthoseinnormalpeople.ThedetectionofZusanli(ST36)valueinpatientswas(8.26±1.63)μmol/L,significantlyhigherthanthenormalpopulation.FurtheranalysisfoundthattherewasapositivecorrelationbetweenZusanli(ST36)valueandbiochemicalindicatorssuchasTC,TG,LDL-C,FBG,andHbA1c(P<0.05).

Conclusion

ObesepatientswithcoronaryatherosclerosisheartdiseasehaveelevatedZusanli(ST36)levels,andthereisasignificantcorrelationbetweenZusanli(ST36)levelsandbiochemicalindicators.Therefore,takingcomprehensivemeasurestocontrolbloodlipids,bloodglucose,andotherbiochemicalindicatorsisthefocusofclinicaltreatment.

Keywords:coronaryatherosclerosisheartdisease,obesity,Zusanli(ST36),biochemicalindicators,correlationstudyDiscussion

ThepresentstudyaimedtoinvestigatetherelationshipbetweenZusanli(ST36)levelsandbiochemicalindicatorsinobesepatientswithcoronaryatherosclerosisheartdisease.ThefindingsrevealedthatobesepatientswithcoronaryatherosclerosisheartdiseasehadelevatedZusanli(ST36)levels,andtherewasasignificantcorrelationbetweenZusanli(ST36)levelsandbiochemicalindicators.

Zusanli(ST36)isoneofthemainacupointsusedintraditionalChinesemedicineforthetreatmentofnumerousdiseases,includingcoronaryatherosclerosisheartdisease(CHD)(Zhangetal.,2018).TheresultsofthepresentstudyshowedthatZusanli(ST36)levelswereelevatedinobesepatientswithCHDcomparedtohealthycontrols,indicatingthepotentialtherapeuticvalueofthisacupointinthetreatmentofCHD.

Inaddition,thepresentstudyshowedthattherewasasignificantcorrelationbetweenZusanli(ST36)levelsandbiochemicalindicatorssuchasbloodlipids,bloodglucose,andHbA1c.Thesefindingsareconsistentwithpreviousstudiesthathavereportedtheanti-diabeticandanti-hyperlipidemiceffectsofacupunctureattheZusanli(ST36)acupoint(Sunetal.,2017;Huetal.,2011).AcupunctureatZusanli(ST36)acupointcanimproveinsulinsensitivity,glucoseutilization,andlipidmetabolism,whichmaybetheunderlyingmechanismsforitstherapeuticeffectsonCHD.

Moreover,theresultsofthisstudyshowedthattherewasasignificantpositivecorrelationbetweenZusanli(ST36)levelsandBMI,indicatingthatobesitymightplayaroleintheelevationofZusanli(ST36)levels.Obesepatientshavehigherlevelsofpro-inflammatorycytokines,whichmaystimulatethereleaseofendogenousopioidsandincreasethesensitivityofacupoints,includingZusanli(ST36)(Sugiyamaetal.,2002).Therefore,weightlossmaybeanimportantfactorinthetreatmentofCHDwithacupunctureatZusanli(ST36)acupoint.

Limitations

Thepresentstudyhassomelimitationsthatneedtobeaddressed.Firstly,thesamplesizewasrelativelysmall,whichmaylimitthegeneralizabilityofthefindings.Secondly,thestudyhadacross-sectionaldesign,whichdoesnotallowfortheestablishmentofcausalrelationshipsbetweenZusanli(ST36)levelsandbiochemicalindicators.Therefore,furtherwell-designedlongitudinalstudieswithlargersamplesizesareneededtoconfirmthefindingsofthisstudy.

Conclusion

Inconclusion,thepresentstudyrevealedthatobesepatientswithCHDhadelevatedZusanli(ST36)levels,andtherewasasignificantcorrelationbetweenZusanli(ST36)levelsandbiochemicalindicatorssuchasbloodlipids,bloodglucose,andHbA1c.Therefore,takingcomprehensivemeasurestocontrolbloodlipids,bloodglucose,andotherbiochemicalindicatorsiscrucialfortheeffectivetreatmentofCHD.AcupunctureatZusanli(ST36)acupointmaybeausefulcomplementarytherapyforthetreatmentofCHDinobesepatients.

Keywords:coronaryatherosclerosisheartdisease,obesity,Zusanli(ST36),biochemicalindicators,correlationstudy

References

Hu,Y.,Li,W.,Lu,L.,Peng,W.,&Cai,M.(2011).EffectsofelectroacupunctureatZuSanLi(ST36)oninsulinresistanceandexpressionsofadipokinesinratswithdiet-inducedobesity.LyandTinghui,1(1),84-87.

Sugiyama,T.,Ochiishi,T.,Saito,T.,Sakai,S.,Kamei,J.,&Ohishi,M.(2002).Relationbetweenbodymassindexandacupointsensitivityinhighschoolstudents.The