Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEMumefuralCat.No.:HY-N8903CASNo.:222973-44-6分?式:C??H??O?分?量:300.22作?靶點(diǎn):Integrin;NF-κB;Toll-likeReceptor(TLR);TNFReceptor作?通路:Cytoskeleton;NF-κB;Immunology/Inflammation;Apoptosis儲(chǔ)存?式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY?物活性MumefuralPrunusmumeSieb加?果實(shí)中的?種?物活性成分。Mumefural抑制??板聚集。Mumefural顯?抗?栓作?，改認(rèn)知障礙。IC50&TargetNF-κBTLR4P-selectinE-selectinTNF-α體內(nèi)研究Mumefural(0.1-10mg/kg;i.p.;once)showsanti-thromboticeffectsinrats[1].Mumefural(20-80mg/kg;oral;dailyfor42days)amelioratescognitiveimpairmentinchroniccerebralhypoperfusionviaregulatingtheseptohippocampalcholinergicsystemandneuroinflammation[2].AnimalModel:SDrats,FeCl3-inducedarterialthrombosismodel[1]Dosage:0.1,1,or10mg/kgAdministration:Intraperitonealinjection,30minbefore35%FeCl3treatmentResult:Significantlyimprovedbloodflowbyinhibitingocclusionandthrombusformation.Preventedcollagenfiberdamageininjuredvesselsandinhibitedtheexpressionoftheplateletactivation-relatedproteinsP-selectinandE-selectin.Significantlyreducedtheincreasedinflammatorysignalofnuclearfactor(NF)-κB,toll-likereceptor4(TLR4),tumornecrosisfactor(TNF)-α,andinterleukin(IL)-6inbloodvessels.1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemEAnimalModel:MaleWistarrats,Chroniccerebralhypoperfusion(CCH)model[2]Dosage:20,40,or80mg/kgAdministration:Oral,onceadayfor42daysResult:Significantlyimprovedcognitiveimpairment.Inhibitedcholinergicsystemdysfunction,attenuatedcholineacetyltransferase-positivecholinergicneuronloss.Inhibitedmyelinbasicproteindegradationandincreasedthehippocampalexpressionofsynapticmarkersandcognition-relatedproteins.Reducedneuroinflammation,inhibitedgliosis,andattenuatedtheactivationofP2X7receptor,TLR4/MyD88,NLRP3,andNF-κB.AnimalModel:SDrats[1]Dosage:2or10mg/kgAdministration:IVorPO(PharmacokineticAnalysis)Result:PlasmapharmacokineticparametersofMumefuralinSDrats[1]T1/2(h)Tmax(h)Cmax(ng/mL)AUC0-t(ng?h/mL)F(%)IV(2mg/kg)0.14±0.050.08±01894.54±580.66564.73±178.35-PO(2mg/kg)0.69±0.690.31±0.131731.61±290.641043.28±202.3736.95±7.17AUC(0–t):areaunderthecurvefromthetimeofdosingtoinfinity;Cmax:maximumconcentration;F:bioavailability;T1/2:terminalhalf-life;Tmax:timeofthemaximumconcentration;SD:standarddeviation;FwascalculatedusingthefollowingformulaREFERENCES[1].BangJ,etal.MumefuralImprovesBloodFlowinaRatModelofFeCl3-InducedArterialThrombosis.Nutrients.2020Dec10;12(12):3795.[2].BangJ,etal.MumefuralAmelioratesCognitiveImpairmentinChronicCerebralHypoperfusionviaRegulatingtheSeptohippocampalCholinergicSystemandNeuroinflammation.Nutrients.2019Nov13;11(11):2755.McePdfHeightCaution:Producthasnotbeenfullyvalidatedfor