組蛋白去乙?；傅慕Y(jié)構(gòu)及應(yīng)用一、本文概述Overviewofthisarticle組蛋白去乙酰化酶（HistoneDeacetylases，HDACs）是一類重要的酶類，通過調(diào)控組蛋白的乙?；癄顟B(tài)來影響基因的表達(dá)，進而參與眾多的生物學(xué)過程。近年來，隨著分子生物學(xué)和生物化學(xué)研究的深入，HDACs的結(jié)構(gòu)和功能逐漸被揭示，其在疾病發(fā)生發(fā)展中的作用也日益受到關(guān)注。本文旨在全面介紹HDACs的結(jié)構(gòu)特點、分類、生物學(xué)功能以及其在醫(yī)學(xué)領(lǐng)域的應(yīng)用，以期為讀者提供一個關(guān)于HDACs的系統(tǒng)性認(rèn)識，并為相關(guān)領(lǐng)域的研究提供參考。Histonedeacetylases(HDACs)areanimportantclassofenzymesthataffectgeneexpressionbyregulatingtheacetylationstatusofhistones,therebyparticipatinginnumerousbiologicalprocesses.Inrecentyears,withthedeepeningofmolecularbiologyandbiochemistryresearch,thestructureandfunctionofHDACshavegraduallybeenrevealed,andtheirroleintheoccurrenceanddevelopmentofdiseaseshasalsoreceivedincreasingattention.Thisarticleaimstocomprehensivelyintroducethestructuralcharacteristics,classification,biologicalfunctions,andapplicationsofHDACsinthemedicalfield,inordertoprovidereaderswithasystematicunderstandingofHDACsandprovidereferencesforresearchinrelatedfields.在結(jié)構(gòu)上，HDACs是一類具有催化活性的酶，其催化核心通常由鋅離子和一系列保守的氨基酸殘基構(gòu)成。根據(jù)氨基酸序列的同源性和催化機制的不同，HDACs可分為多個不同的家族和亞型。這些不同的HDACs在細(xì)胞內(nèi)的分布、底物特異性以及調(diào)控機制上各有特點，共同維持著細(xì)胞內(nèi)乙?；癄顟B(tài)的動態(tài)平衡。Structurally,HDACsareaclassofenzymeswithcatalyticactivity,andtheircatalyticcoreistypicallycomposedofzincionsandaseriesofconservedaminoacidresidues.Accordingtothehomologyofaminoacidsequencesanddifferentcatalyticmechanisms,HDACscanbedividedintomultipledifferentfamiliesandsubtypes.ThesedifferentHDACshavetheirowncharacteristicsinintracellulardistribution,substratespecificity,andregulatorymechanisms,collectivelymaintainingadynamicbalanceofintracellularacetylation.在生物學(xué)功能上，HDACs通過調(diào)控組蛋白的乙?；?，影響染色質(zhì)的結(jié)構(gòu)和基因的表達(dá)。HDACs還可以調(diào)控非組蛋白的乙?；?，從而參與細(xì)胞周期、細(xì)胞分化、凋亡、自噬等多種生物學(xué)過程。因此，HDACs在腫瘤、神經(jīng)退行性疾病、心血管疾病等多種疾病的發(fā)生發(fā)展中扮演著重要角色。Intermsofbiologicalfunction,HDACsaffectchromatinstructureandgeneexpressionbyregulatingtheacetylationlevelofhistones.HDACscanalsoregulatetheacetylationofnonhistones,therebyparticipatinginvariousbiologicalprocessessuchascellcycle,differentiation,apoptosis,andautophagy.Therefore,HDACsplayanimportantroleintheoccurrenceanddevelopmentofvariousdiseasessuchastumors,neurodegenerativediseases,andcardiovasculardiseases.在應(yīng)用方面，HDACs已成為藥物研發(fā)的重要靶點。通過抑制HDACs的活性，可以恢復(fù)細(xì)胞內(nèi)乙?；癄顟B(tài)的平衡，從而達(dá)到治療疾病的目的。目前，已有多種HDAC抑制劑被開發(fā)出來，并在臨床試驗中顯示出一定的療效。隨著對HDACs結(jié)構(gòu)和功能的深入研究，未來有望發(fā)現(xiàn)更多具有潛力的藥物靶點和治療策略。Intermsofapplication,HDACshavebecomeimportanttargetsfordrugdevelopment.ByinhibitingtheactivityofHDACs,thebalanceofintracellularacetylationcanberestored,therebyachievingthegoaloftreatingdiseases.Atpresent,variousHDACinhibitorshavebeendevelopedandhaveshowncertaintherapeuticeffectsinclinicaltrials.Within-depthresearchonthestructureandfunctionofHDACs,itisexpectedtodiscovermorepotentialdrugtargetsandtreatmentstrategiesinthefuture.本文將對HDACs的結(jié)構(gòu)、分類、生物學(xué)功能以及應(yīng)用進行全面介紹，旨在為讀者提供一個關(guān)于HDACs的系統(tǒng)性認(rèn)識，并為相關(guān)領(lǐng)域的研究提供參考。Thisarticlewillcomprehensivelyintroducethestructure,classification,biologicalfunctions,andapplicationsofHDACs,aimingtoprovidereaderswithasystematicunderstandingofHDACsandprovidereferencesforresearchinrelatedfields.二、組蛋白去乙?；傅慕Y(jié)構(gòu)特性Structuralcharacteristicsofhistonedeacetylase組蛋白去乙?；福℉istoneDeacetylases,HDACs）是一類關(guān)鍵的酶，通過移除組蛋白和其他蛋白質(zhì)上的乙?；鶊F，參與調(diào)控基因表達(dá)、細(xì)胞周期、細(xì)胞分化、凋亡等多種生物過程。HDACs的結(jié)構(gòu)特性對于理解其功能和應(yīng)用至關(guān)重要。Histonedeacetylases(HDACs)areakeyclassofenzymesthatparticipateinregulatingvariousbiologicalprocessessuchasgeneexpression,cellcycle,celldifferentiation,andapoptosisbyremovingacetylgroupsfromhistonesandotherproteins.ThestructuralcharacteristicsofHDACsarecrucialforunderstandingtheirfunctionsandapplications.HDACs的分子結(jié)構(gòu)通常包括一個催化核心區(qū)和一個可變的調(diào)節(jié)區(qū)。催化核心區(qū)含有保守的催化活性位點，負(fù)責(zé)催化去乙?；磻?yīng)。這個區(qū)域通常具有一個深而窄的活性口袋，能夠特異性地識別并結(jié)合乙?；嚢彼釟埢?。催化核心區(qū)的結(jié)構(gòu)高度保守，不同HDACs之間的催化機制相似。ThemolecularstructureofHDACstypicallyincludesacatalyticcoreregionandavariableregulatoryregion.Thecatalyticcoreregioncontainsconservedcatalyticactivesitesresponsibleforcatalyzingdeacetylationreactions.Thisregiontypicallyhasadeepandnarrowactivepocketthatcanspecificallyrecognizeandbindacetylatedlysineresidues.Thestructureofthecatalyticcoreregionishighlyconserved,andthecatalyticmechanismsbetweendifferentHDACsaresimilar.調(diào)節(jié)區(qū)則負(fù)責(zé)調(diào)控HDACs的活性、定位和相互作用。這個區(qū)域的結(jié)構(gòu)和序列在不同HDACs之間差異較大，使得HDACs具有不同的生物學(xué)特性和功能。一些HDACs的調(diào)節(jié)區(qū)包含與其他蛋白質(zhì)相互作用的結(jié)構(gòu)域，如鋅指結(jié)構(gòu)、螺旋-轉(zhuǎn)角-螺旋結(jié)構(gòu)等，這些結(jié)構(gòu)域使得HDACs能夠與其他蛋白質(zhì)形成復(fù)合物，從而調(diào)控其活性。Theregulatoryregionisresponsibleforregulatingtheactivity,localization,andinteractionofHDACs.ThestructureandsequenceofthisregionvarygreatlyamongdifferentHDACs,resultingindifferentbiologicalcharacteristicsandfunctionsofHDACs.SomeregulatoryregionsofHDACscontainstructuraldomainsthatinteractwithotherproteins,suchaszincfingerstructures,helixturnhelixstructures,etc.ThesedomainsenableHDACstoformcomplexeswithotherproteins,therebyregulatingtheiractivity.除了催化核心區(qū)和調(diào)節(jié)區(qū)，HDACs還可能包含其他輔助結(jié)構(gòu)域，如核定位信號（NLS）和核輸出信號（NES）等。這些結(jié)構(gòu)域負(fù)責(zé)調(diào)控HDACs在細(xì)胞內(nèi)的定位和分布，從而影響其在不同生物過程中的作用。Inadditiontothecatalyticcoreandregulatoryregions,HDACsmayalsocontainotherauxiliarystructuraldomains,suchasnuclearlocalizationsignals(NLS)andnuclearoutputsignals(NES).ThesedomainsareresponsibleforregulatingthelocalizationanddistributionofHDACswithincells,therebyinfluencingtheirrolesindifferentbiologicalprocesses.通過對HDACs結(jié)構(gòu)特性的深入研究，科學(xué)家們不僅可以更好地理解這些酶的生物學(xué)功能，還可以開發(fā)出更有效的HDAC抑制劑，用于治療癌癥、神經(jīng)退行性疾病等多種疾病。因此，對HDACs結(jié)構(gòu)特性的研究具有重要的理論和應(yīng)用價值。Throughin-depthresearchonthestructuralcharacteristicsofHDACs,scientistscannotonlybetterunderstandthebiologicalfunctionsoftheseenzymes,butalsodevelopmoreeffectiveHDACinhibitorsforthetreatmentofvariousdiseasessuchascancerandneurodegenerativediseases.Therefore,thestudyofthestructuralcharacteristicsofHDACshasimportanttheoreticalandpracticalvalue.三、組蛋白去乙?；冈谏飳W(xué)中的應(yīng)用Theapplicationofhistonedeacetylaseinbiology組蛋白去乙?；福℉DACs）在生物學(xué)中發(fā)揮著至關(guān)重要的作用，它們通過調(diào)控組蛋白的乙?；癄顟B(tài)，進而影響染色質(zhì)的結(jié)構(gòu)和功能，參與眾多生物過程。這些過程包括但不限于基因轉(zhuǎn)錄、DNA修復(fù)、細(xì)胞周期調(diào)控、細(xì)胞分化以及細(xì)胞凋亡等。Histonedeacetylases(HDACs)playacrucialroleinbiologybyregulatingtheacetylationstateofhistones,therebyaffectingthestructureandfunctionofchromatinandparticipatinginnumerousbiologicalprocesses.Theseprocessesincludebutarenotlimitedtogenetranscription,DNArepair,cellcycleregulation,celldifferentiation,andapoptosis.HDACs在基因轉(zhuǎn)錄調(diào)控中起到關(guān)鍵作用。組蛋白的乙?；娇梢灾苯佑绊戅D(zhuǎn)錄因子與DNA的結(jié)合能力，從而調(diào)控基因的轉(zhuǎn)錄水平。HDACs通過去除組蛋白上的乙?；鶊F，使得染色質(zhì)結(jié)構(gòu)變得更為緊密，進而抑制基因轉(zhuǎn)錄。這種調(diào)控機制在細(xì)胞的生長、分化和凋亡過程中發(fā)揮著重要作用。HDACsplayacrucialroleingenetranscriptionregulation.TheacetylationlevelofhistonescandirectlyaffectthebindingabilityoftranscriptionfactorstoDNA,therebyregulatingthetranscriptionlevelofgenes.HDACsinhibitgenetranscriptionbyremovingacetylgroupsfromhistones,makingchromatinstructuremorecompact.Thisregulatorymechanismplaysanimportantroleinthegrowth,differentiation,andapoptosisprocessesofcells.HDACs也參與DNA損傷修復(fù)過程。在DNA受到損傷時，HDACs可以通過調(diào)控染色質(zhì)結(jié)構(gòu)，使得DNA修復(fù)蛋白能夠更有效地識別和修復(fù)損傷。這一過程中，HDACs的活性對于維持基因組穩(wěn)定性和防止細(xì)胞突變具有重要意義。HDACsarealsoinvolvedintheprocessofDNAdamagerepair.WhenDNAisdamaged,HDACscanregulatechromatinstructure,enablingDNArepairproteinstomoreeffectivelyrecognizeandrepairdamage.Duringthisprocess,theactivityofHDACsisofgreatsignificanceformaintaininggenomicstabilityandpreventingcellmutations.HDACs還在細(xì)胞周期調(diào)控和細(xì)胞分化中發(fā)揮重要作用。通過調(diào)控特定基因的轉(zhuǎn)錄水平，HDACs可以影響細(xì)胞周期蛋白的表達(dá)，從而調(diào)控細(xì)胞周期的進程。同時，HDACs還可以參與細(xì)胞分化過程中基因表達(dá)的調(diào)控，對于維持細(xì)胞的正常分化狀態(tài)具有重要意義。HDACsalsoplayimportantrolesincellcycleregulationandcelldifferentiation.Byregulatingthetranscriptionlevelsofspecificgenes,HDACscanaffecttheexpressionofcyclin,therebyregulatingtheprogressionofthecellcycle.Meanwhile,HDACscanalsoparticipateintheregulationofgeneexpressionduringcelldifferentiation,whichisofgreatsignificanceformaintainingthenormaldifferentiationstateofcells.近年來，隨著對HDACs研究的深入，人們發(fā)現(xiàn)HDACs與多種疾病的發(fā)生和發(fā)展密切相關(guān)。例如，在癌癥中，HDACs的異常表達(dá)常常導(dǎo)致腫瘤細(xì)胞的增殖失控和凋亡受阻。因此，HDACs已成為癌癥治療的重要靶點之一。通過抑制HDACs的活性，可以恢復(fù)染色質(zhì)的正常結(jié)構(gòu)和功能，從而抑制腫瘤細(xì)胞的增殖并誘導(dǎo)其凋亡。目前，已有多種HDAC抑制劑被開發(fā)并應(yīng)用于癌癥治療，取得了顯著的臨床效果。Inrecentyears,withthedeepeningofresearchonHDACs,ithasbeenfoundthatHDACsarecloselyrelatedtotheoccurrenceanddevelopmentofvariousdiseases.Forexample,incancer,abnormalexpressionofHDACsoftenleadstouncontrolledproliferationandinhibitionofapoptosisoftumorcells.Therefore,HDACshavebecomeoneoftheimportanttargetsforcancertreatment.ByinhibitingtheactivityofHDACs,thenormalstructureandfunctionofchromatincanberestored,therebyinhibitingtheproliferationoftumorcellsandinducingtheirapoptosis.Atpresent,variousHDACinhibitorshavebeendevelopedandappliedincancertreatment,achievingsignificantclinicaleffects.組蛋白去乙?；冈谏飳W(xué)中發(fā)揮著至關(guān)重要的作用，它們通過調(diào)控染色質(zhì)的結(jié)構(gòu)和功能參與眾多生物過程。隨著對HDACs研究的深入，人們對于其在生物學(xué)中的應(yīng)用和潛在價值有了更加清晰的認(rèn)識。未來隨著HDACs抑制劑的不斷發(fā)展和優(yōu)化，它們在疾病治療中的應(yīng)用前景將更加廣闊。Histonedeacetylasesplayacrucialroleinbiologybyregulatingthestructureandfunctionofchromatinandparticipatinginnumerousbiologicalprocesses.WiththedeepeningofresearchonHDACs,peoplehavegainedaclearerunderstandingoftheirapplicationsandpotentialvalueinbiology.WiththecontinuousdevelopmentandoptimizationofHDACsinhibitorsinthefuture,theirapplicationprospectsindiseasetreatmentwillbeevenbroader.四、組蛋白去乙?；敢种苿┑难邪l(fā)與應(yīng)用Developmentandapplicationofhistonedeacetylaseinhibitors隨著對組蛋白去乙?；福℉DACs）功能的深入理解，針對這些酶的抑制劑已經(jīng)成為一種重要的藥物開發(fā)方向。組蛋白去乙酰化酶抑制劑（HDACi）的研發(fā)與應(yīng)用，不僅有助于揭示HDACs在細(xì)胞生物學(xué)中的重要作用，也為多種疾病的治療提供了新的策略。Withadeeperunderstandingofthefunctionsofhistonedeacetylases(HDACs),inhibitorstargetingtheseenzymeshavebecomeanimportantdirectionfordrugdevelopment.Thedevelopmentandapplicationofhistonedeacetylaseinhibitors(HDACi)notonlyhelptorevealtheimportantroleofHDACsincellbiology,butalsoprovidenewstrategiesforthetreatmentofvariousdiseases.HDACi的研發(fā)主要基于其能夠調(diào)節(jié)基因表達(dá)、影響細(xì)胞周期、誘導(dǎo)細(xì)胞凋亡等生物學(xué)功能。目前，已經(jīng)有多種HDACi進入臨床試驗階段，用于治療包括癌癥、神經(jīng)退行性疾病以及炎癥性疾病在內(nèi)的多種疾病。這些抑制劑的作用機制主要是通過抑制HDACs的活性，提高組蛋白的乙酰化水平，從而影響基因轉(zhuǎn)錄和細(xì)胞命運。ThedevelopmentofHDACiismainlybasedonitsbiologicalfunctionssuchasregulatinggeneexpression,affectingcellcycle,andinducingcellapoptosis.Atpresent,variousHDACihaveenteredtheclinicaltrialstageforthetreatmentofvariousdiseasesincludingcancer,neurodegenerativediseases,andinflammatorydiseases.ThemainmechanismofactionoftheseinhibitorsistoinhibittheactivityofHDACs,increasetheacetylationlevelofhistones,andthusaffectgenetranscriptionandcellfate.在癌癥治療中，HDACi的應(yīng)用尤為引人注目。由于許多癌癥細(xì)胞的HDACs活性升高，HDACi可以通過誘導(dǎo)癌細(xì)胞凋亡、抑制癌細(xì)胞增殖和遷移等方式，發(fā)揮抗癌作用。HDACi還可以增強其他抗癌藥物的療效，提高治療效果。TheapplicationofHDACiisparticularlynoteworthyincancertreatment.DuetotheincreasedactivityofHDACsinmanycancercells,HDACicanexertanti-cancereffectsbyinducingcancercellapoptosis,inhibitingcancercellproliferationandmigration,andsoon.HDACicanalsoenhancetheefficacyofotheranti-cancerdrugsandimprovetreatmentoutcomes.除了癌癥治療，HDACi在神經(jīng)退行性疾病和炎癥性疾病的治療中也展現(xiàn)出潛在的應(yīng)用價值。例如，一些研究表明，HDACi可以改善阿爾茨海默病、帕金森病等神經(jīng)退行性疾病的癥狀，減輕神經(jīng)元損傷。在炎癥性疾病中，HDACi可以通過調(diào)節(jié)炎癥因子的表達(dá)，減輕炎癥反應(yīng)，從而緩解疾病癥狀。Inadditiontocancertreatment,HDACialsodemonstratespotentialapplicationvalueinthetreatmentofneurodegenerativeandinflammatorydiseases.Forexample,somestudieshaveshownthatHDACicanimprovethesymptomsofneurodegenerativediseasessuchasAlzheimer'sandParkinson's,andreduceneuronaldamage.Ininflammatorydiseases,HDACicanalleviatediseasesymptomsbyregulatingtheexpressionofinflammatoryfactors,alleviatinginflammatoryresponses.然而，HDACi的應(yīng)用也面臨一些挑戰(zhàn)。HDACs家族有多個成員，不同成員的功能和分布具有差異性，因此開發(fā)具有選擇性的HDACi是一個重要的研究方向。HDACi的副作用也是需要考慮的問題，如長期應(yīng)用可能導(dǎo)致毒性積累等。因此，未來HDACi的研發(fā)需要在提高選擇性和降低副作用方面做出更多努力。However,theapplicationofHDACialsofacessomechallenges.TheHDACsfamilyhasmultiplemembers,andthefunctionsanddistributionofdifferentmembersvary.Therefore,developingselectiveHDACiisanimportantresearchdirection.ThesideeffectsofHDACialsoneedtobeconsidered,suchasthepotentialaccumulationoftoxicityduetolong-termuse.Therefore,futureresearchanddevelopmentofHDACineedstomakemoreeffortsinimprovingselectivityandreducingsideeffects.組蛋白去乙?；敢种苿┑难邪l(fā)與應(yīng)用為疾病治療提供了新的途徑。隨著研究的深入和技術(shù)的進步，我們有望開發(fā)出更加高效、安全的HDACi，為人類的健康事業(yè)做出更大的貢獻。Thedevelopmentandapplicationofhistonedeacetylaseinhibitorsprovidenewavenuesfordiseasetreatment.Withthedeepeningofresearchandtechnologicalprogress,weareexpectedtodevelopmoreefficientandsafeHDACi,makinggreatercontributionstohumanhealth.五、組蛋白去乙?；傅奈磥碚雇鸉utureprospectsofhistonedeacetylases組蛋白去乙酰化酶（HDACs）作為調(diào)控基因表達(dá)的重要酶類，已經(jīng)在癌癥、神經(jīng)生物學(xué)、表觀遺傳學(xué)等多個領(lǐng)域引起了廣泛的關(guān)注。盡管我們已經(jīng)對HDACs的結(jié)構(gòu)和功能有了相當(dāng)深入的了解，但其在生命體系中的復(fù)雜性和多樣性仍然讓我們對其未來充滿了期待。Histonedeacetylases(HDACs),asimportantenzymesthatregulategeneexpression,haveattractedwidespreadattentioninvariousfieldssuchascancer,neurobiology,andepigenetics.AlthoughwehavegainedaconsiderableunderstandingofthestructureandfunctionofHDACs,theircomplexityanddiversityinlifesystemsstillmakeuslookforwardtotheirfuture.在未來，隨著生物技術(shù)的不斷進步，我們有望更深入地理解HDACs在細(xì)胞中的精確作用機制。例如，通過高分辨率的顯微成像技術(shù)，我們可以觀察到HDACs在活細(xì)胞中的動態(tài)行為，從而揭示其在不同生理和病理過程中的具體作用。新的高通量篩選方法也將助力我們尋找和發(fā)現(xiàn)更多的HDACs抑制劑，這些藥物有可能成為未來癌癥治療的新武器。Inthefuture,withthecontinuousadvancementofbiotechnology,weareexpectedtohaveadeeperunderstandingoftheprecisemechanismofactionofHDACsincells.Forexample,throughhigh-resolutionmicroscopyimagingtechnology,wecanobservethedynamicbehaviorofHDACsinlivingcells,therebyrevealingtheirspecificrolesindifferentphysiologicalandpathologicalprocesses.Thenewhigh-throughputscreeningmethodwillalsohelpussearchforanddiscovermoreHDACsinhibitors,whichmaybecomenewweaponsforfuturecancertreatment.在疾病治療方面，HDACs抑制劑的應(yīng)用前景尤為廣闊。目前，已有多種HDACs抑制劑進入臨床試驗階段，它們在治療多種癌癥、神經(jīng)退行性疾病以及病毒感染等方面顯示出了良好的療效。隨著對HDACs功能的進一步了解，我們有望開發(fā)出更加精準(zhǔn)、高效的藥物，以滿足臨床的需求。Intermsofdiseasetreatment,theapplicationprospectsofHDACsinhibitorsareparticularlybroad.Atpresent,variousHDACsinhibitorshaveenteredtheclinicaltrialstage,andtheyhaveshowngoodtherapeuticeffectsintreatingvariouscancers,neurodegenerativediseases,andviralinfections.WithfurtherunderstandingofthefunctionsofHDACs,wehavethepotentialtodevelopmorepreciseandefficientdrugstomeetclinicalneeds.除了疾病治療，HDACs在農(nóng)業(yè)和生物技術(shù)領(lǐng)域也有著潛在的應(yīng)用價值。例如，通過調(diào)控HDACs的活性，我們可以實現(xiàn)對植物或動物基因表達(dá)的精準(zhǔn)調(diào)控，從而培育出具有優(yōu)良性狀的新品種。HDACs還可能成為生物傳感器和生物標(biāo)記物的重要工具，用于監(jiān)測和診斷疾病。Inadditiontodiseasetreatment,HDACsalsohavepotentialapplicationvalueinthefieldsofagricultureandbiotechnology.Forexample,byregulatingtheactivityofHDACs,wecanachievepreciseregulationofgeneexpressioninplantsoranimals,therebycultivatingnewvarietieswithexcellenttraits.HDACsmayalsobecomeimportanttoolsforbiosensorsandbiomarkersformonitoringanddiagnosingdiseases.組蛋白去乙酰化酶的未來充滿了無限的可能性。隨著科學(xué)技術(shù)的不斷進步，我們有望更深入地理解這一生命體系中的重要分子，并將其應(yīng)用于疾病治療、農(nóng)業(yè)生物技術(shù)等多個領(lǐng)域，為人類健康和生活質(zhì)量的提升做出更大的貢獻。Thefutureofhistonedeacetylasesisfullofinfinitepossibilities.Withthecontinuousprogressofscienceandtechnology,weareexpectedtohaveadeeperunderstandingoftheimportantmoleculesinthislifesystemandapplythemtovariousfieldssuchasdiseasetreatmentandagriculturalbiotechnology,makinggreatercontributionstotheimprovementofhumanhealthandqualityoflife.六、結(jié)論Conclusion組蛋白去乙?；福℉DACs）作為一類重要的酶類，在生物體的多種生理和病理過程中發(fā)揮著不可或缺的作用。通過對其結(jié)構(gòu)的深入研究和理解，我們已經(jīng)能夠認(rèn)識到這些酶如何精確地調(diào)控組蛋