Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEBMPagonist2Cat.No.:HY-158203CASNo.:1438900-88-9分?式:C??H??NO?分?量:305.33作?靶點(diǎn):Others作?通路:Others儲(chǔ)存?式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.溶解性數(shù)據(jù)體外實(shí)驗(yàn)DMSO:100mg/mL(327.51mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制備儲(chǔ)備液1mM3.2751mL16.3757mL32.7515mL5mM0.6550mL3.2751mL6.5503mL10mM0.3275mL1.6376mL3.2751mL體內(nèi)實(shí)驗(yàn)請(qǐng)根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥?式選擇適當(dāng)?shù)娜芙?案。以下溶解?案都請(qǐng)先按照InVitro?式配制澄的儲(chǔ)備液，再依次添加助溶劑：(為保證實(shí)驗(yàn)結(jié)果的可靠性，澄的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；體內(nèi)實(shí)驗(yàn)的?作液，建議您現(xiàn)?現(xiàn)配，當(dāng)天使?；以下溶劑前顯?的百分?指該溶劑在您配制終溶液中的體積占?；如在配制過(guò)程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過(guò)加熱和/或超聲的?式助溶)1.請(qǐng)依序添加每種溶劑：10%DMSO>>40%PEG300>>5%Tween-80>>45%salineSolubility:≥2.5mg/mL(8.19mM);Clearsolution2.請(qǐng)依序添加每種溶劑：10%DMSO>>90%(20%SBE-β-CDinsaline)Solubility:≥2.5mg/mL(8.19mM);ClearsolutionBIOLOGICALACTIVITY1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemE?物活性BMPagonist2(derivativeI-9)?種有效的?誘導(dǎo)細(xì)胞因?。BMPagonist2通過(guò)增加成?細(xì)胞的?例和活性，促進(jìn)?組織的?成。BMPagonist2通過(guò)BMP2-ATF4信號(hào)軸促進(jìn)成?細(xì)胞的增殖和分化，其中ATF4?個(gè)與成?細(xì)胞分化和?形成密切相關(guān)的轉(zhuǎn)錄因?。BMPagonist2可?于?年性?質(zhì)疏松癥(SOP)的研究[1]。REFERENCES[1].ZhouZ,etal.Efficacy,Mechanism,andStructure–ActivityRelationshipof6-MethoxyBenzofuranDerivativesasaUsefulToolforSenileOsteoporosis[J].JournalofMedicinalChemistry,2023,66(3):1742-1760.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792ax: