高質(zhì)量細(xì)胞培養(yǎng)用細(xì)胞因子高純度低內(nèi)毒素高活性完善的質(zhì)量控制體系北京義翹神州科技股份有限公司01高質(zhì)量細(xì)胞培養(yǎng)用細(xì)胞因子細(xì)胞的體外培養(yǎng)需要添加合適的細(xì)胞因子，以維持其正常的生長(zhǎng)、增殖或者分化。高質(zhì)量細(xì)胞因子在CAR-T/CAR-NK細(xì)胞治療、類器官培養(yǎng)及干細(xì)胞治療等熱門(mén)領(lǐng)域顯得尤為重要，直接關(guān)系到最終應(yīng)用的成敗。義翹神州針對(duì)不同細(xì)胞培養(yǎng)的實(shí)際需求，精心設(shè)計(jì)、研發(fā)和生產(chǎn)了一系列高純度、高活性、高穩(wěn)定性、低內(nèi)毒素的特色細(xì)胞因子產(chǎn)品，特別適用于免疫細(xì)胞、干細(xì)胞、類器官等體外培養(yǎng)應(yīng)用場(chǎng)景。另外，為滿足新藥研發(fā)的不同階段的各個(gè)環(huán)節(jié)，我們提供GMP級(jí)、RUO級(jí)細(xì)胞因子，全面加速生物藥的研發(fā)上市進(jìn)程。純度大于95%，經(jīng)SDS

&

SEC-HPLC驗(yàn)證高活性，經(jīng)ELISA、cell-based

assays驗(yàn)證

高批間一致性無(wú)標(biāo)簽或小標(biāo)簽表達(dá)資質(zhì)證書(shū)2024年值得關(guān)注的生長(zhǎng)因子供應(yīng)商CNAS證書(shū)FDA

DMF備案ISO

9001:2015證書(shū)ISO

13485:2016證書(shū)GMP證書(shū)制劑不含載體蛋白低內(nèi)毒素水平：<5?10

EU/mg經(jīng)過(guò)類器官、免疫細(xì)胞、干細(xì)胞等培養(yǎng)驗(yàn)證

ISO9001/ISO13485/GMP質(zhì)量控制體系產(chǎn)品優(yōu)勢(shì)高質(zhì)量細(xì)胞培養(yǎng)用細(xì)胞因子北京義翹神州科技股份有限公司高質(zhì)量細(xì)胞培養(yǎng)用細(xì)胞因子02細(xì)胞因子功能介紹細(xì)胞因子生物學(xué)作用培養(yǎng)類型EGF調(diào)節(jié)和促進(jìn)表皮細(xì)胞的生長(zhǎng)與增殖促進(jìn)角膜、皮膚等傷口修復(fù)干細(xì)胞：ESC/iPSC、NSC、MSC類器官：腸道、胃、腦、肝臟、肺、胰腺、前列腺、乳腺、內(nèi)耳、血 管、甲狀腺FGF2誘導(dǎo)內(nèi)皮細(xì)胞生長(zhǎng)和增殖促進(jìn)血管新生維持多能干細(xì)胞的自我更新和未分化狀態(tài)干細(xì)胞：ESC/iPSC、NSC、MSC免疫細(xì)胞：T細(xì)胞類器官：腸道、心臟、腦、肝臟、肺、腎臟、胰腺、前列腺、乳腺、內(nèi)耳、血管FGF10促進(jìn)上皮細(xì)胞的增殖和遷移調(diào)節(jié)肺、胃和皮膚等組織的發(fā)育和修復(fù)過(guò)程參與細(xì)胞分化、血管生成和神經(jīng)細(xì)胞生長(zhǎng)促進(jìn)傷口愈合調(diào)節(jié)肢體和肺等多器官發(fā)育干細(xì)胞：ESC/iPSC、NSC

類器官：胃、心臟、肝臟、肺、胰腺、前列腺、乳腺、甲狀腺VEGF165增強(qiáng)內(nèi)皮細(xì)胞的增殖和存活促進(jìn)血管生成增強(qiáng)血管通透性干細(xì)胞：ESC/iPSC、NSC、HSC免疫細(xì)胞：NK細(xì)胞、樹(shù)突細(xì)胞、粒細(xì)胞類器官：血管Activin

A促進(jìn)下丘腦、垂體和性腺激素的合成與分泌調(diào)節(jié)細(xì)胞增殖、分化、傷口修復(fù)以及組織和器官 形成干細(xì)胞：ESC/iPSC類器官：腸道、胃、心臟、肝臟、肺、前列腺GM-CSF促進(jìn)粒細(xì)胞和巨噬細(xì)胞的生長(zhǎng)和發(fā)育促進(jìn)骨髓細(xì)胞的產(chǎn)生和分化參與傷口愈合干細(xì)胞：HSC免疫細(xì)胞：?jiǎn)魏思?xì)胞/巨噬細(xì)胞、樹(shù)突細(xì)胞、粒細(xì)胞FGF4調(diào)節(jié)胚胎發(fā)育、細(xì)胞增殖和細(xì)胞分化促進(jìn)心肌血管生成，脊椎動(dòng)物肢體發(fā)育促進(jìn)再上皮化和傷口愈合與胃癌發(fā)展相關(guān)干細(xì)胞：ESC/iPSC、NSC、MSC類器官：腸道、胃、心臟、腦、肝臟、腎、甲狀腺I(mǎi)FN-γ調(diào)節(jié)和增強(qiáng)機(jī)體的免疫反應(yīng)抗病毒和抗腫瘤作用調(diào)控細(xì)胞生長(zhǎng)和分化促進(jìn)炎癥反應(yīng)干細(xì)胞：HSC免疫細(xì)胞：T細(xì)胞、NK細(xì)胞、單核細(xì)胞/巨噬細(xì)胞、樹(shù)突細(xì)胞、

B細(xì)胞說(shuō)明：

ESC/iPSC：胚胎干細(xì)胞/誘導(dǎo)性多能干細(xì)胞；NSC：神經(jīng)干細(xì)胞；MSC：間充質(zhì)干細(xì)胞；HSC：造血干細(xì)胞。北京義翹神州科技股份有限公司03高質(zhì)量細(xì)胞培養(yǎng)用細(xì)胞因子Human

FGF-10

Protein,

HPLC-verified

(Cat#:

10573-HNAE)經(jīng)肺、腎、胃、肝癌、腎癌、乳腺癌、胃癌等9種類器官培養(yǎng)驗(yàn)證人小腸類器官 人胃類器官產(chǎn)品驗(yàn)證數(shù)據(jù)Human

small

intestinal

organoids

werecultured

with

IL22

(Cat#:

13059-HNAE),FGF10

(Cat#:

10573-HNAE),EGF

(Cat#:

50482-MNCH),NOG

(Cat#:

50688-M02H).Data

provided

by

D1

Medical

Technology.Human

stomach

organoids

were

culturedwith

EGF

(Cat#:

50482-MNCH),FGF10

(Cat#:

10573-HNAE),NOG

(Cat#:

50688-M02H),RSPO1

(Cat#:

11083-HNAS).Data

provided

by

D1

Medical

Technology.Human

gastric

cancer

organoids

werecultured

with

EGF

(Cat#:

50482-MNCH),FGF10

(Cat#:

10573-HNAE),NOG

(Cat#:

50688-M02H),RSPO1

(Cat#:

11083-HNAS).Data

provided

by

D1

Medical

Technology.Human

R-Spondin

1/RSPO1

Protein,

HPLC-verified

(Cat#:

11083-HNAS)結(jié)直腸癌類器官LM-P2Day

7 Day

10 Day

14(B)不同形態(tài)的mCRC類器官培養(yǎng)過(guò)程；(C）原發(fā)腫瘤和患者衍生類器官的組織病理學(xué)特征。來(lái)源:/10.3389/fbioe.2023.1190637Day

1Day

3BFH&ETissue Organoid

OrganoidCRC-

PDO5CRC-

PDO30B

cOM-P6CRC-P10CRC-P14人胃癌類器官Human

FGF-10

Protein,

HPLC-verified

(Cat#:

10573-HNAE)人肺類器官 人肺癌類器官Human

lung

organoids

were

cultured

withFGF2

(Cat#:

10014-HNAE),FGF4(Cat#:

16043-HNAE),FGF7

(Cat#:

10210-H07E),EGF

(Cat#:

50482-MNCH),FGF10

(Cat#:

10573-HNAE),NOG

(Cat#:

50688-M02H),RSPO1

(Cat#:

11083-HNAS).Data

provided

by

D1

Medical

Technology.Human

lung

cancer

organoids

werecultured

with

FGF2

(Cat#:

10014-HNAE),FGF4

(Cat#:

16043-HNAE),FGF7

(Cat#:

10210-H07E),EGF

(Cat#:

50482-MNCH),FGF10

(Cat#:

10573-HNAE),NOG

(Cat#:

50688-M02H),RSPO1

(Cat#:

11083-HNAS).Data

provided

by

D1

Medical

Technology.Human

kidney

organoids

were

culturedwith

FGF7

(Cat#:

10210-H07E),EGF

(Cat#:

50482-MNCH),FGF10

(Cat#:

10573-HNAE),NOG

(Cat#:

50688-M02H),RSPO1

(Cat#:

11083-HNAS),HGF

(Cat#:

10463-HNAS),FGF4

(Cat#:

16043-HNAE).Data

provided

by

D1

Medical

Technology.人腎類器官北京義翹神州科技股份有限公司高質(zhì)量細(xì)胞培養(yǎng)用細(xì)胞因子04產(chǎn)品驗(yàn)證數(shù)據(jù)Human

EGF

Protein,

HPLC-verified

(Cat#:

10605-HNAE)Three

independent

batches

of

human

EGFprotein

(Cat#:

10605-HNAE)

have

i

dentical

bioactivity.160140120100806040200-20Proliferation,%1E-4

1E-3

0.01

0.1

1

10

100Human

EGF

(ng/mL)高批間一致性Batch

1Batch

2Batch

3iPSC-derived

human

vascular

organoids

werecultured

with

FGF2

(Cat#:

10014-HNAE),

VEGF165(Cat#:

11066-HNAH),

EGF

(Cat#:

10605-HNAE).Red

arrows

represent

vascular

organoids.Human

basic

FGF/FGF2

Protein

(Cat#:

10014-HNAE)人肝癌類器官 人膽管癌類器官Human

liver

cancer

organoids

werecultured

with

FGF2

(Cat#:

10014-HNAE),HGF

(Cat#:

10463-HNAS),FGF7

(Cat#:

10210-H07E),EGF

(Cat#:

50482-MNCH),FGF10

(Cat#:

10573-HNAE),TGFB1

(Cat#:

10804-HNAC),NOG

(Cat#:

50688-M02H),RSPO1

(Cat#:

11083-HNAS).Data

provided

by

D1

Medical

Technology.Human

cholangiocarcinoma

organoidswere

cultured

withFGF2

(Cat#:

10014-HNAE),HGF

(Cat#:

10463-HNAS),FGF7

(Cat#:

10210-H07E),EGF

(Cat#:

50482-MNCH),FGF10

(Cat#:

10573-HNAE),NOG

(Cat#:

50688-M02H),RSPO1

(Cat#:

11083-HNAS).Data

provided

by

D1

Medical

Technology.Human

kidney

cancer

organoids

werecultured

with

FGF2

(Cat#:

10014-HNAE),FGF7

(Cat#:

10210-H07E),EGF

(Cat#:

50482-MNCH),FGF10

(Cat#:

10573-HNAE),NOG

(Cat#:

50688-M02H),RSPO1

(Cat#:

11083-HNAS).Data

provided

by

D1

Medical

Technology.人腎癌類器官高純度HUVEC成管實(shí)驗(yàn)高純度人血管類器官5

10

15

20

25

min≥

95%

as

determined

by

SDS-PAGE.≥

95%

as

determined

by

SEC-HPLC.mAU

400350300250200150100500kDa

M

11666.245.035.025.018.414.4Human/Cynomolgus

VEGF165

Protein

(Cat#:

11066-HNAH)Measured

in

a

cell

proliferation

assayusing

human

umbilical

vein

endothelialcells

(HUVEC).Induction

of

tube

formation

in

human

umbilicalvein

endothelial

cells

(HUVECs)

in

vitro.5

10

15

20 25

min≥

95%

as

determined

by

SDS-PAGE.≥

95%

as

determined

by

SEC-HPLC.mAU05101520kDa

M

11666.245.035.025.018.414.4Proliferation%0.01

0.1110

100VEGF165

Conc.

(ng/mL)活性驗(yàn)證義翹神州ED50=1.4

(ng/mL)10090

進(jìn)口品牌ED50=4.0

(ng/mL)80706050403020100北京義翹神州科技股份有限公司05高質(zhì)量細(xì)胞培養(yǎng)用細(xì)胞因子Human

IFN

gamma

Protein(Cat#:

11725-HNAE)Activin

A

Protein(Cat#:

10429-HNAH)Human

IL-2

Protein(Cat#:

11848-HNAE2)Human

Flt3

Ligand

Protein(Cat#:

10315-HNAE)Human

IL-21

Protein(Cat#:

10584-HNAE)Human

SCF

Protein(Cat#:

10451-HNAE)產(chǎn)品驗(yàn)證數(shù)據(jù)≥

95%

as

determined

by

SDS-PAGE.≥

95%

as

determined

by

SEC-HPLC.Measured

in

anti-viral

assays

using

WISHcells

infected

with

vesicular

stomatitisvirus(VSV).Measured

by

its

ability

to

inhibit

proliferationof

MPC-11

cells.5

10

15

20 25

min≥

95%

as

determined

by

SDS-PAGE.≥

95%

as

determined

by

SEC-HPLC.Measured

in

a

cell

proliferation

assay

usingTF-1

human

erythroleukemic

cells.Measured

in

a

cell

proliferation

assay

usingCTLL2.5

10

15

20 25

min≥

95%

as

determined

by

SDS-PAGE.≥

95%

as

determined

by

SEC-HPLC.Measured

in

a

cell

proliferation

assay

usingM-NFS-60

mouse

myelogenous

leukemialymphoblast

cells.5

1015

20 25

minmAU

12010080604020011666.245.035.025.018.414.4kDa

M0.800.750.700.650.600.550.50ED50=8-80

pg/mL0.1

1

10

100Human

IFN

gamma

Conc.

(pg/mL)OD-Blank2040601008001E-41E-3

0.01

0.1

1 10

100

1000Activin

A

Conc.(ng/mL)Inhibition

%50ED

=0.5-5

ng/mLmAU

10080604020011666.245.035.025.018.414.4kDa

MmAU250200150100500kDa

M

11666.245.035.025.018.414.41E-5

1E-4

1E-3

0.01

0.1 1

10

100-500300025002000150010005000Proliferation

%Human

GM-CSF

Conc.

(ng/mL)Human

GM-CSF

Protein(Cat#:

10015-HNAH)3500

ED50=0.06-0.3ng/mL25002000150010005000-5000.1

1

10Human

IL-2

Conc.

(ng/mL)3000

ED50=1-8

ng/mLProliferation,%120010008006004002000-200-4001E-4

1E-3

0.01

0.1

1 10

100Human

IL-21

Conc.

(ng/mL)Measured

by

its

ability

to

induce

Interfer-on-gamma

secretion

by

human

naturalkiller

lymphoma

NK-92

cells.1400

ED

=0.4-2ng/mL50Proliferation,%0.01

0.1

1

10

100Human

Flt3

Ligand

Conc.

(ng/mL)Measured

in

a

cell

proliferation

assay

usingBaF3

mouse

proB

cells

transfected

withmouse

Flt3.5004003002001000Proliferation,%50ED

=1-6

ng/mL5

10

15

20 25

min≥

95%

as

determined

by

SDS-PAGE.≥

95%

as

determined

by

SEC-HPLC.Measured

in

a

cell

proliferation

assay

usingTF-1

human

erythroleukemic

cells.18.4mAU

kDa

M60

11666.250

45.040

35.030

25.020

14.41001E-3

0.01

0.1

1 10

100

1000Human

SCF

Conc.

(ng/mL)50040040030020020010000Proliferation,%ED50=1-8

ng/mL1400120010008006004002000-200Proliferation

%0.01

0.1

1

10 100

1000Human

M-CSF

Conc.

(ng/mL)Human

M-CSF

Protein(Cat#:

11792-HNAH1)1600

ED50=3-15

ng/mL北京義翹神州科技股份有限公司高質(zhì)量細(xì)胞培養(yǎng)用細(xì)胞因子06細(xì)胞因子貨號(hào)種屬SEC-HPLC純度內(nèi)毒素宿主Activin

A10429-HNAHHuman,Mouse,

Rat,Cynomolgus,

Rhesus≥

95%<

10

EU/mgHEK293

CellsBMP-210426-HNAE1Human,Mouse,

Rat,Rhesus,

Canine≥

95%

(SDS)<

10

EU/mgE.

coliBMP410609-HNAE2Human≥

95%

(SDS)<

1.0

EU/μgE.coliDKK-110170-H08HHuman≥

95%<

10

EU/mgHEK293

CellsEGF10605-HNAEHuman≥

95%<

5

EU/mgE.

coliFGF210014-HNAEHuman≥

95%

(SDS)<

10

EU/mgE.

coliFGF-416043-HNAEHuman≥

95%<

10

EU/mgE.

coliFGF-910262-HNAEHuman≥

95%<

10

EU/mgE.

coliFGF-1010573-HNAEHuman≥

95%<

5

EU/mgE.

coliFGF-2110911-HNAEHuman≥

95%

(SDS)<

10

EU/mgE.

coliFlt3

Ligand10315-HNAEHuman≥

95%<

10

EU/mgE.

coliG-CSF10007-HNAHHuman≥

95%<

10

EU/mgHEK293

CellsGDNF10561-HNAEHuman≥

95%<

10

EU/mgE.

coliGM-CSF10015-HNAHHuman≥

95%<

10

EU/mgHEK293

CellsHGF10463-HNASHuman≥

95%<

10

EU/mgCHO

Stable

CellsIFN

gamma11725-HNAEHuman≥

95%<

5

EU/mgE.

coli11725-H08HHuman≥

95%<

1.0

EU/μgHEK293

CellsIL-1

beta10139-HNAEHuman≥

95%<

5

EU/mgE.

coliIL-211848-HNAE2Human≥

95%<

5

EU/mgE.

coliIL-311858-HNAEHuman≥

95%<

5

EU/mgE.

coliIL-411846-HNAEHuman≥

95%<

5

EU/mgE.

coliIL-610395-HNAEHuman≥

95%

(SDS)<

10

EU/mgE.

coliIL-711821-HNAEHuman≥

95%<

10

EU/mgE.

coliIL-1010947-HNAEHuman≥

90%<20

EU/mgE.

coliIL-12CT011-H08HHuman≥

95%<

5

EU/mgHEK293

CellsCT050-HNAHHuman≥

95%<

5

EU/mgHEK293

Cells高活性細(xì)胞因子產(chǎn)品列表GMP-grade

availableAnimal-free

available北京義翹神州科技股份有限公司07高質(zhì)量細(xì)胞培養(yǎng)用細(xì)胞因子高活性細(xì)胞因子產(chǎn)品列表細(xì)胞因子貨號(hào)種屬SEC-HPLC純度內(nèi)毒素宿主IL-1510360-HNCEHuman≥

95%

(SDS)<20

EU/mgE.

coliIL-1810119-HNCEHuman>

95%<

10

EU/mgE.

coliIL-2110584-HNAEHum