注：不含主觀題第1題單選題(1分)Thattheimmunecellssensingandeliminatingthealteredcellsiscalled().AImmunologicalbalancingBImmunologicalmemoryCImmunologicalsurveillanceDImmunologicalhomeostasisEImmunologicaldefense第2題單選題(1分)()hastheabilitytoproduceimmunememory.ABasophilBNeutrophilCEosinophilDMonocyteETcell正確答案：E第3題單選題(1分)Whathappenstoapathogenasitbecomesattenuated?()AItbecomesmoredangeroustothehost.BItgetssmaller.CItbecomestoooldtoinitiatetheimmuneresponse.DIthasweakenedvirulence.EItbecomesmoreinvasivetothehost.第4題單選題(1分)Thescientistwhodevelopedcowpoxasvaccinetoprotecthumanfromgettingsmallpoxis().AEdwardJennerBLouisPasteurCEmilvonBehringDRobertKochEElieMetchnikoffTestofPart2第1題單選題(1分)Variableregionsarelocatedonthe(

）.ABothlightchainsofimmunoglobulinBBothheavychainsofimmunoglobulinCOnelightchainandoneheavychainofimmunoglobulinDBothlightchainsandheavychainsofimmunoglobulinEOnlylightchainsofimmunoglobulin第2題單選題(1分)()aregeneratedwhenIgGisdigestedbypapain.ATwoFabandoneFcBOneF(ab’)2andoneFc’

COneF(ab’)2

DOneFabandoneFcETwoFab

第3題單選題(1分)IfapersonhadamutationinthegeneencodingJ(joining)chains,whichofthefollowingclassesofantibodiescouldNOTbeproduced?()AIgA

andIgMBIgA

andIgGCIgG

andIgEDIgD

andIgEEIgG

andIgM第4題單選題(1分)Oneofthedifferencesbetweenanormalimmuneresponseandallergicreactionisthelevelof()AIgMBIgECIgGDIgAEIgDTestofPart3第1題單選題(1分)TowhichofthefollowingsisMBLmoststructurallysimilar?()AC3bBBbCC1qDC5bEC1r第2題單選題(1分)WhichofthefollowingcomplementfixationpathwayscanbeinitiatedbyasolubleC3convertase?()AAlternativeBClassicalCLectinDAlternativeandclassicalEAlternativeandlectin第3題單選題(1分)WhichofthefollowingisINCORRECTinregardtotheclearingofthemicrobefromthehostmediatedbyCR1bindingofcomplement-opsonizedmicrobes?()AItpromotesthephagocytosisofopsonizedmicrobesbyleukocytesBItinitiatesthesecretionofproinflammatorycytokinesCItmediatesthephagocytosisofC3b-opsonizedpathogenbymacrophagesDItpromotesthecaptureofmicrobesbyredbloodcellsEItprovidesthesignalforTcellsactivation正確答案：E第4題單選題(1分)WhichofthefollowingsisNOTthebiologicalconsequenceofcomplementactivation?()ATargetcelllysisBRemovalofimmunecomplexCNeutralizationoftoxinDInflammationEOpsonizationTestofPart4第1題單選題(1分)()isimportantforBcellstosampletheantigensinthelymphnodes.ANaturalkillerBSubcapsularsinusmacrophagesCNa?veTcellsDActivatedTcellsEHelperTcells第2題單選題(1分)Whichofthefollowingsiscorrectinregardtothehumoralimmuneresponse?()AThehumoralimmuneresponseusuallyoccursintheinfectionlocation.BThehumoralimmuneresponsetoTDantigensdoesnotrequiretheinvolvementofTcells.CDuringaprimaryhumoralresponse,IgMissecretedinitially,oftenfollowedbyaswitchtoanincreasingproportionofIgG.DTheactivationofTcellsrequires

twosignals,whereasBcellsactivationdoesnot.ETandBcellsrecognizethesameepitopeonthesameantigen.第3題單選題(1分)DuringthehumoralimmuneresponsetoTD-Ag,ThareNOTinvolvedintheprocessof().AAffinitionofmaturationBSpecificcytotoxicitytoantigensCSurvivalofBcellsDActivationofBcellsEClassswitchingofIg第4題單選題(1分)WhichofthefollowingdescriptionsisINCORRECT?()ATheaffinitymutationofantibodyismainlytheresultofsomatichypermutationandselectioninthegeminalcenter.BClassswitchingallowstheselectedBcellstoproduceantibodieswithavarietyofeffectorfunctions.CFolliculardendriticcellsandTfollicularhelpersareimportantforBcellstoproduceamoreeffectiveantibodyresponse.DFolliculardendriticcellsarerichlyendowedwithbothFcreceptorsandcomplementreceptorstoaccumulatetheantigensforBcellsbinding.EThegenerationofantibodydiversitymainlyoccursinthegerminalcenter.正確答案：ETestofPart5第1題單選題(1分)WhichofthefollowingisNOTahumanMHCgene?____AABCCDPDDREK正確答案：E第2題單選題(1分)YourchancesofhavingthesameMHChaplotypeasyoursiblingare:____A1:1B1:2C1:4D1:8E1:16第3題單選題(1分)MHCImoleculesarefoundinallcellsofourbodyexcept____ADendriticcellsBTcellsCmaturalredbloodcellsDlivercells第4題單選題(1分)Atmost,howmanydifferentclassicalclassIMHCmoleculesarethereoneachnucleatedcellinahuman?____AOneBTwoCThreeDSix第5題單選題(1分)HLAdeterninantscanbeusedforonesetofmarkersinpaternitytesting.Giventhefollowingphenotypes,whichofthepotentialfathersismostlikelytheactualbiologicalfather____?ThephenotypefortheoffspringisHLA-A:A3,33;HLA-B:B54,59;HLA-C:C5,8ThephenotypeforthebiologicalmotherisHLA-A:A3,11;HLA-B:B59,78;HLA-C:C8,8AHLA-A:A3,33;HLA-B:B56,27;HLA-C:C5,5BHLA-A:A11,33;HLA-B:B54,27;HLA-C:C5,6CHLA-A:A11,33;HLA-B:B59,26;HLA-C:C6,8DHLA-A:A3,3;HLA-B:B54,27;HLA-C:C5,5TestofPart6第1題答題卡(綠色代表正確，紅色代表錯誤，無色代表未答）總分：{n}分試卷得分：{n}分未作答：個未批改：個第2題單選題(1分)WhichofthefollowingisNOTahumanMHCgene?____AABCCDPDDREK正確答案：E第3題單選題(1分)YourchancesofhavingthesameMHChaplotypeasyoursiblingare:____A1:1B1:2C1:4D1:8E1:16第4題單選題(1分)MHCImoleculesarefoundinallcellsofourbodyexcept____ADendriticcellsBTcellsCmaturalredbloodcellsDlivercells第5題單選題(1分)Atmost,howmanydifferentclassicalclassIMHCmoleculesarethereoneachnucleatedcellinahuman?____AOneBTwoCThreeDSixTestofPart7第1題單選題(1分)Whichofthefollowingstatementscorrectlydescribestheexogenouspathwayofantigenprocessing?____AEnablestheactivationofCD4+TcellsBGeneratesantigensfromcytoplasmicpathogensCInvolvesthegenerationofpeptidesbyproteasomeactivityDRequirestheactionofTransporterassociatedwithantigenprocessing(TAP)tomobilisesmallcytosolicpeptidesintotheERlumen第2題單選題(1分)Whichofthefollowingisanexampleofcross-presentation?____AAnendogenouspeptidebeingpresentedonMHCclassIBAnexogenouspeptidebeingpresentedonMHCclassICAnendogenouspeptidebeingpresentedonMHCclassIIDAnexogenouspeptidebeingpresentedonMHCclassIIEAB-cellantigenbeingpresentedtoaTcell第3題單選題(1分)Forpathogenpeptidestobeseenasforeign,theymustbedisplayedonaTcellinthecontextofa/an:____AB-cellmarkerBCDmoleculeCIgMmoleculeDMHCpeptideEpattern-recognitionreceptormolecule第4題單選題(1分)ThecellsthatdisplaypeptidesassociatedwithclassIIMHCmoleculestoCD4+thecellsarecalledantigenpresentationcells.Inthefollowingcells,____arethenon-professionalantigenpresentingcells?AMacrophagesBDendriticcellsCFibroblastsDBlymphocytes第5題單選題(1分)IthasbeenlearnedinseveralexperimentalsystemsthatproliferationanddifferentiationofTlymphocytesinresponsetotumorcellsislowbecausetumorcellslackthenecessaryco-stimulatorymoleculesforlymphocyteactivation.Ifmelanomacellsfromapatientwereinducedtoexpresstheseco-stimulatorymoleculesbytransfection,productionofaneffectiveanti-tumorresponsemightoccur.Whichofthefollowingmolecules____wouldbethebestcandidatefortransfectionoftumorcellstoachievethisend?AB7BCD2CCD4DCD28ELFA-1TestofPart8第1題單選題(1分)Theroleofcell-mediatedimmunityis:____AtoeliminatetheoutercellularpathogensBtof