Hotline:400-820-3792Inhibitors ? ScreeningLibraries ? Proteinswww.MedChemEα-Amylase-IN-13Cat.No.:HY-178363CASNo.:3085413-64-2分子式:C??H??F?N?O?S?分子量:426.44作用靶點:Amylases作用通路:MetabolicEnzyme/Protease儲存方式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY生物活性α-Amylase-IN-13是一種具有口服活性、選擇性、可穿透血腦屏障的α-淀粉酶(α-amylase)抑制劑(IC50=0.71μM)。α-Amylase-IN-13通過混合抑制機制抑制α-淀粉酶。α-Amylase-IN-13可顯著降低糖尿病大鼠的血糖水平。α-Amylase-IN-13可導致腎臟、肝臟和胰腺的組織病理學顯著改善。α-Amylase-IN-13可用于糖尿病并發(fā)癥的研究[1]。體內研究α-Amylase-IN-13(Compound5r)(10mg/kg,oralgavage,oncedailyfor14days)caneffectivelycontrolStreptozotocin(HY-13753)-induceddiabetesinratsandreducecomplications[1].AnimalModel:MaleWistarrats(200–250gbodyweight)aftera12-hfastingperiod,type1diabetesmellituswasinducedintraperitoneallybyIPinjectionofstreptozotocin(STZ)atadoseof55mg/kg[1].Dosage:10mg/kgAdministration:Oralgavage,oncedailyfor14daysResult:Exhibitedanotabledecreaseinbloodglucoselevels,indicatingenhancedglycemiccontrol.Significantlyimprovedtheserumlevelsofurea,creatinine,HbA1c,AST,ALT,andALP.Demonstratedremarkablerecoverywiththemildcongestivehepaticsinusoids,significantlyreducedlipiddroplets,andfewerballoonedhepatocytes.Showedremarkablyreducedsignsofpathologicaltissuedamage.Enhancedtheisletcellintegrityandfunction.1/2 MasterofBioactiveMolecules—您身邊的抑制劑大師www.MedChemEREFERENCESRaviA,etal.Synthesis,invitroandinvivoevaluation,andcomputationalmodelinganalysisofthioxothiazolidinederivativesashighlypotentandselectiveα-amylaseinhibitors.EurJMedChem.2025Jul5;291:117584.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;0