第1題Whichoneofthefollowingbooksistheearliestmedicinebook?ATheYellowEmperor’sInnerClassic.BTheGrandCompendiumofMateriaMedica.CShenNong'sHerbalClassic.DMateriaMedicaArrangedAccordingtoPattern.第2題“Threeformulas

and

threemedicines”wereapprovedbyCFDAfortheCOVID-19indication.Choosethreeofthefollowingformulasbelongto“Threeformulas”.AQingfeiPaiduDecoction(清肺排毒湯)BHuashiBaiduformula(化濕敗毒方)CXuanfeiBaiduformula(宣肺敗毒方)DBuyangHuanwuDecoction(補(bǔ)陽還五湯)正確答案：ABC第3題“Threeformulas

and

threemedicines”wereapprovedbyCFDAfortheCOVID-19indication.Choosethreeofthefollowingmedicinesbelongto“Threemedicines”.AShuangHuangLianOralLiquid(雙黃連口服液)BLianhuaQingwenCapsule(連花清瘟膠囊)CJinhuaQingganGranule(金花清感顆粒)DXueBiJingIntravenous(血必凈注射液)正確答案：DCB第4題TherecoveryratewithTCMinCOVID-19treatmentinChinaismorethanA60%B70%C80%D90%第5題WhichoneisnotthecontentofQingfeiPaiduDecoction?AHuangQin(ScutellariaeRadix)BZeXie(AlismatisRhizoma)CChaiHu(BupleuriRadix)DHuangQi(AstragaliRadix)第6題InstituteforChineseMateriaMedica(ICMM)ofTsinghuauniversitywasformallyestablishedinA2016B2017C2018D2019第7題WhichstatementaboutISO/TC249isnotcorrect?AStandardizationinthefieldofmedicalsystemsderivedfromancientChinesemedicinewhichshallbeabletoshareonecommonsetofstandards.BInternationalorganizationforstandardization/traditionalChinesemedicinetechnicalcommittee.CThecommitteefocusesonqualityandsafetyofrawmaterials,manufacturedproductsandmedicaldevicesandofinformatics.DOnlytraditionalaspectsarecovered.第8題SkullcapherbismostprobablytakenfromAShanxiprovince.BShaanxiprovince.CHainanprovince.DGuangdongprovince.正確答案：AB第9題Whichapplicationofskullcapisnotcorrect?ATreatmentoffevercausedbytheflu.BReducesinflammation.CTreatmentofthereproductivesystemdiseases.DFightcancercells.第10題Whichoneofthefollowingcomponentsisthemarkerofskullcaps?ABaicalin.BWogonin.CScutellarein.DChrysin.第11題第1題WhatisthetargetofRemdesivir?ARdRpBSproteinCACE2DDNApolymerase第2題WhatwillbetheactiveformofRemdesivir?AalaninemetaboliteBmonophosphateCdiphosphateDtriphosphate第3題ChooseallthepotentialmechanismsofRibavirinAinhibitionofRNAreplicationBinhibitIMPDHCRNAmutagenesisDmodulateimmunesystem正確答案：DCBA第4題Whichoneistheadenineanalogue?ARemdesivirBFavipiravirCRibavirinDPenciclovir第5題Whichstatementaboutproteaseinhibitorisnotcorrect?APLproandMproaretwotypicalproteasethatcanbetargetedasthetherapeutictargetsforCOVID-19BDisulfiram,LopinavirandCamostatcanallbindtoPLproCDisulfiramworksasacompetitiveinhibitorforSARScoronavirusDDisulfiramworksasacompetitiveinhibitorforMERScoronavirus第6題Whatisnottheadvantageofvirus-targetinginhibitors?AveryspecificBlesstoxicCeasyforvirustogeneratemutantDbroadspectrum正確答案：CD第7題WhatisthedownstreamofdihydroorotatethatisinvolvedinRNAsynthesis?AorotateBUMPCUDPDUTP第8題WhereisDHODHinthecell?AcytosolBnucleusCmitochondriaDlysosome第9題Whichstatementiscorrect?AThalidomidecansuppressvirusreplication,overactivatedNF-ΚBandproinflammatorycytokinesBChloroquinecanreducetheproductionofpro-inflammatorycytokinesanddisruptviralSproteinCNiclosamidecaninhibitSKP2,enhanceautophagy,thereby,itcanstoptheMERS-CoVreplicationDCamostatandNafamostataretwoTMPRSS2inhibitorsthatcanblockcoronavirusspikeproteindrivenentryintothehostcell正確答案：DCBA第10題Whichmethodcouldfacilitatethediscoveryofnoveltargetsforcoronavirustreatment?AvirtualscreeningBmappingofprotein-proteininteractionCnucleotideanaloguesynthesisDvaccination第11題Lecture3homework第1題WhichisthefollowingAItechnologyisprimarilyusedinliteraturemining?()ANLPBBayesianNetworkCGameTheoryDTree-Search第2題Whattypeofdeeplearningalgorithmisbestformolecularpropertyprediction?()AGraph-CNNBRNNCGANDK-Means第3題Whichalgorithmisusedforgenomesequencealignmentandsimilarityranking?()ALSTMBEMCBLASTDKNN第4題WhichtargetoftheSARS-CoV-2isconservedatcatalyticalsitecomparedwithSARS-CoV?()ARdRpB3CLproCPLproDTransferase第5題WhichhumanreceptorissharedbetweenSARS-CoVandSARS-CoV-2?()AACE2BCLEC4MCCD209DCD147第6題WhattechnologyisusedinthecoursetosimulatetheinteractionbetweenSARS-CoV-2anditshumanreceptor?()AMMBQMCDFTDMD第7題Whichtypeofstatisticalmeasurementwasusedinthecoursetomeasuretheperformanceofligand-basedAIpredictionmodels?()AaccuracyBAUCCcorrelationcoefficientDR^2第8題Whichcompoundlibrarycanbeusedfordrugrepurposing?()AFDAapprovedlibraryBCommercialcompoundLibrariesCVirtualhypotheticalcompoundlibrariesDPubChemlibrary第9題Whatisthemainpurposeoftheproject“NextStrain”?()APredictthelocationofthenextoutbreakBPredictthegenomesequenceofthenextoutbreakCTracktimeandlocationsofSARS-CoV-2mutationsDPredictthetimeofthenextoutbreak第10題WhichofthefollowisNOTanadvantageofcurrentAItechnologyinDrugDiscovery?()AFastanalysisBBroadKnowledgeCObjectivejudgementDGeneratingHypothesis第11題第12題Lecture4homework第1題Howmanypathwaysarethereforcoronavirustoenterthehostcell?A1B2C3D4第2題Whatproteinsareusedtocleavepolyproteinstoproducenonstructuredproteins?ARdRpB3CLproteaseCPLproteaseDHelicase正確答案：BC第3題Whatapproachcanbeusedforidentificationofnewchemicalhits?ATargetidentificationBPK/PDpredictionCVirtualscreeningDADMETprediction第4題Whatcontributestoprotein-ligandinteraction?AHydrogenbondBhydrophobicinteractionCwaterreleaseDproteinsize正確答案：ABC第5題Whichbindingmodelindicatesprotein/receptorisrigid?ALock-keyBInduced-fitCConformationselectionDAllostericmodel第6題Whichfactorsareimportantinthesuccessofvirtualscreening?ALargeandDiversecompoundlibraryBproteinsizeCscoringaccuracyDwatermodel正確答案：AC第7題WhichonesareNOTcorrectregardinghomologymodeling?AHomologymodelingisatemplate-freemethodforstructurepredictionBItisstillchallengingtopredictthestructureforhardtargetsCHomologymodelcanbedirectlyusedforstructure-baseddrugdesignwithoutevaluationorrefinementDHomologymodelingrepliesonthegrowthofknownstructures正確答案：AC第8題WhichoneisNOTcorrectregardingSARS-CoV-23CLprotease?AItisattractivetargetduetotheexistenceofviralproteaseinhibitorsdevelopedforHIVandothervirusesBItisaserineproteaseCDimerconformationisneededforthein-silicomodelingagainstthistargetDThehomologymodelbasedontheSARS-CoV3CLproisreliableforrealapplication第9題WhatstrategyisNOTusedinthevirtualscreeningagainst3CLprotease?AEnsembledockingBforce-fieldbasedrescoringCMDsimulationDshapescreening第10題Whatareimportantfordesigningcovalentinhibitors?ASelectivewarheadBmicrosomestabilityCpeptide-likeDsolubility正確答案：DBALecture5homework第1題Whichofthefollowingarebiologics?

AOligonucleotidesBInsulinCPenicillinDEngineeredcells正確答案：DBA第2題Whichdescriptionaboutbiologicsiswrong?ABiologicscannotdiffusethroughthecellmembraneBBiologicscommonlyhavelargermolecularweightthanchemicaldrugsCBiologicsaremostlyadministeredbyinjectionDBiologicscanaccessanytherapeutictarget第3題WhatreceptoronhumancellsdirectlybindstoSARS-CoV-2?AADAM17BACE2CSpikeproteinDDPP4第4題ScientistaredevelopingtherapeuticantibodiesagainstwhichoftheSARS-CoV-2protein?ARNApolymeraseBProteaseCSpikeproteinDNucleoprotein第5題Whatpropertyisthemostcriticalforthetherapeuticanti-SARS-CoV-2antibody?

AHighstabilityBLongcirculationtimeCBindingtoSproteinDNeutralizingtheSARS-CoV-2virus第6題Whichmethod(s)areusedtodeveloptherapeuticanti-SARS-CoV-2antibody?AConvalescentplasmatherapyBScreeningforcross-reactivityinexistinganti-SARS-CoV-1antibodyCPhagedisplaytechnologyDSortingpatientBcellsandsingleBcellcloning正確答案：DCB第7題Whichdescription(s)aboutimmunomodulatoryantibodiesis/areincorrect?AImmunomodulatoryantibodiesblockthevirusentryinlungepithelialcellsBImmunomodulatoryantibodiessuppresstheimmunereactiontoSARS-CoV-2CImmunomodulatoryantibodiessynergizewithanti-viraltreatmentDTocilizumab(Actemra?)andsarilumab(Kevzara?)wereoriginallydevelopedforSARS正確答案：DA第8題WhattargetsareunderinvestigationtomanagetheimmunereactioninCOVID-19?AIL-6RBIL-6CGM-CSFDCCR5正確答案：DCBA第9題第10題第11題Lecture6homework第1題What

does

the

Red

Queen

hypothesis

tell

usintermsoftherelationshipbetweenhumanandvirus?

()AHuman

have

to

fight

against

virusBViruses

are

undefeatableCBoth

virus

and

their

host

arecontinuously

evolvedDVirus

and

their

host

remain

the

same第2題Whichis

the

first

step

of

the

virus

life

circle?

()Athe

release

of

new

virus

particlesBthebindingbetweentheSproteinandtheACE2receptorCthe

endocytosis

of

virus

particleDthe

translation

of

new

virus

protein第3題WhichinthefollowingdoesNOTbelongtotheinnateimmunity?()ABlymphocytes(Bcells)BPhagocyticcellsCInterferonDNaturalkillercells第4題Whichdescriptionaboutinterferoniscorrect?()AInterferonishostspecificaswellasvirusspecificBItcannotbeproducedbyvirtuallyanycellCTherearefourtypesofinterferon(IFN)knownsofarDInterferonisthefirstlineofdefenseagainstvirusesbeforeaspecificinmuuneresponseismounted第5題WhichtargetCANNOTactivateNaturalkiller()cells?()AAntibodycoatedcellsBCellsinfectedbyvirusesandsomeintracellularbacteriaCTcellsDCellslackingclassIMHCmolecules第6題WhatpercentageofhumangenomesincludingEndogenousRetrovirus()?()AAbout8%ofhumangenomeBAbout18%ofhumangenomeCAbout28%ofhumangenomeDAbout38%ofhumangenome第7題MHCClassIImoleculespresentpeptidesmadeoutsidethecellto()ACD8+helperTcellsBCD4+helperTcellsCCD8+CD4cellsDHelperTcells第8題MHCClassImoleculespresentpeptidesmadeinsidethecellto()ACD8+helperTcellsBCD4+helperTcellsCCD8+cytotoxicTcellsDCD4+cytotoxicTcells第9題Antiviraltherapycantargetthefollowingaspectsexcept().AVirusitselfBHostcellmetabolismCHostimmunesystemDAntibodiesinhosts第10題Whichresponseorcellisnotincludedininnateimmuneresponses?()ATcellresponsesBPhagocytosisCInterferonsDNKcells第11題第12題第13題WhatpercentageofhumangenomesincludingEndogenousRetrovirus(ERV)?()AAbout8%ofhumangenomeBAbout18%ofhumangenomeCAbout28%ofhumangenomeDAbout38%ofhumangenomeLecture7homework第1題WhichisnotthereasonforeffectivetrackingoftheCOVID-19spreadinglately?AThemassivenucleic-acidtestingwaspossibleBPositivesampleswerefoundinchopboardCPeoplehavegotexperiencesincontainingthevirusDTherewerelessconfirmedcases第2題Whichdescriptionaboutvirusiswrong?AVirusgenerallyhasanoutsideshellmadeofproteinBViruscancarryproteaseinsideCViruscanproliferateonitsownDSurfaceproteincanservethefunctionfordockingontoitshost第3題3Whichmethodcouldbeusedtoquicklyconfirmthesuccessfulcollectionofanunknownpathogenbeforenucleicacidsequencing?APhysicalmeasurementBCytopathiceffectCDetectionofproteinsDDetectionofgeneticmaterials第4題Whyantibodiesareusuallypreferredtotargetproteinsforquickat-home