1、高雄醫(yī)學大學藥學院藥學系暨藥學研究所吳 寶 珠 教授藥劑學及生物藥劑學 研究室 任教科目 - （A）大學部： （B）藥學研究所：藥劑學 藥劑學特論藥劑學實驗 高級藥劑學特論 最高學歷 - 高雄醫(yī)學院藥學研究所 藥學博士 經(jīng)歷 - 高雄醫(yī)學大學藥學系 副教授 (1998/8 -2004/7)高雄醫(yī)學院藥學系 講師 (1992/8-1998/7) 高雄醫(yī)學院藥學系 助教 (1987/8-1992/7)美國 北卡大學 研究學者 (2005/8-2005/12)美國 匹茲堡大學 研究學者 (2005/1-2005/7)日本星藥科大學 外國人員客座研究員 (1999/6-1999/9) 最新動態(tài) - 藥

2、學系導師 E-mail - .tw 聯(lián)絡(luò)電話 - (07)-3121101 ext. 2660傳 真 - (07)-3210683 研究室網(wǎng)頁： 研究專長 - 藥物輸送系統(tǒng)之研究 著作論文代表（2001年迄今）1. Jia-You Fang, Song-Yih Yu, Pao-ChuWu, Yaw-Bin Huang, and Yi-Hung Tsai. 2001. In vitro skin permeation of estradiol from various proniosome formulations. Int. J. Pharm., 215, 91-99

3、.2. Jia-You Fang, Ren-Jiunn Wang, Yaw-Bin, Huang, Pao-Chu Wu, and Yi-Hung Tsai, 2001. Influence of electrical and chemical factors on transdermal iontophoretic delivery of diclofenac salts. Biol. Pharm. Bull. 24 (4),390-394. 3. Yaw-Bin, Huang, Min-Jun Tsai, Pao-Chu Wu, Chia-Lin Tsai, Jui-I Chang, an

4、d Yi-Hung Tsai, 2001. Transdermal esterdiol delivery from volatile vehicles through excised rabbit skin: effect of lipophilic enhancers. N. Taipei J. Med. 3, 107-114.4. Pao-Chu Wu, Jui-Sheng Chang, Yaw-Bin Huang, Chee-Yin Chai, and Yi-Hung Tsai, 2001. Evaluation of percutaneous absorption and skin i

5、rritation of ketoprofen through rat skin : in vitro and in vivo study. Int J. Pharm. 222, 225-235. 5. Pao-Chu Wu, Yasuko Obata, Mikito Fujikawa, Chao Jie Li, Kimio Higashiyama, Kozo Takayama, 2001. Simultaneous optimization based on artificial neural networks in ketoprofen hydrol formula containing

6、o-ethyl-3-butylcyclohexanol as percutaneous absorption enhancer. J. Pharm. Sci. 90, 1004-1014. 6. Li-Fang Wang, How-N Chiang, and Pao-Chu Wu, 2002. Kinetics and hydrolysis mechanism of polymeric prodrug containing ibuprofen, ketoprofen and naproxen as pendent agents. J. Biomater. Sci. Polymer Edn. 1

7、3 (3) 287-299.7. Min-Jun Tsai , Yaw-Bin Huang, Pao-Chu Wu, Hui-Chuan Chen, and Yi-Hung Tsai*,2002, Monitoring Amino Acid Neurotransmitters in Plasma Profiles and Predicting Early Progression of Ischemic Stroke. Chin. Pharm. J. 54, 215-224.8. Yaw-Bin Huang, Yi-Hung Tsai, Jui-Sheng Chang, Jian-Chen Li

8、u, Min-Jun Tsai, and Pao-Chu Wu*, 2002. Effect of Antioxidants and Anti-irritants on the Stability, Skin Irritation and Penetration Capacity of Captopril Gel . Int. J. Pharm. 241, 345-351. 9. Pao-Chu Wu, Min-Jun Tsai, Yaw-Bin Huang, Jui-Sheng Chang, and Yi-Hung Tsai* , 2002. In vitro and in vivo eva

9、luation of potassium chloride sustained release formulation prepared with saturated polyglycolyed glycerides matrices. Int. J. Pharm. 243 (1-2) 119-124. 10. Pao-Chu Wu, Yaw-Bin Huang, Jui-Sheng Chang, Ming-Jun Tsai, and Yi-Hung Tsai*, 2003, Design and evaluation of sustained release microspheres of

10、potassium chloride prepared by Eudragit®. Eur. J. Pharm. Sci.19(2-3) 115-122.11. Pao-Chu Wu, Yaw-Bin Huang, Jui-I Chang, Ming-Jun Tsai, and Yi-Hung Tsai*, 2003, Preparation and evaluation of sustained release microspheres of potassium chloride prepared with Ethylcellulose Int. J. Pharm. 260, 11

11、5-121.12. Yaw-Bin Huang, Jia-You Fang, Pao-Chu Wu, Ysung-Hsien Chen, Ming-Jun Tsai, and Yi-Hung Tsai*, 2003, Noninvasive glucose monitoring by back diffusion via skin: chemical and physical and physical enhamcements. Biol. Pharm. Bull. 26 (7), 983-987.13. Jui-I Chang, Yaw-Bin Huang, Pao-Chu Wu, Chao

12、-Cheng Chen,Shun-Chen Huang, and Yi-Hung Tsaib,*2003, Characterization of human cervical precancerous tissue through the Fourier transform infrared microscopy with mapping method. Gynecologic Oncology 91 (2003) 577583.14. Ming-Jun Tsai*, Yaw-Bin Huang, Pao-Chu Wu, 2003. A novel clinical pattern of v

13、isual hallucination after zolpidem use. J. toxicol., Clin. toxicol. 41(6), 869-872. 15. Pao-Chu Wu, Yi-Hung Tsai, Chung-Cheng Liao, Jui-Sheng Chang, Yaw-Bin Huang*, 2004. The characterization and biodistribution of cefoxitin-loaded liposomes. Int. J. Pharm. 271, 31-39. 16. Yaw-Bin Huang, Jui-Sheng C

14、hang, Jian-Chen Liu, Min-Jun Tsai, Yi-Hung Tsai, and Pao-Chu Wu*. 2004. The influence of anti-irritants on captopril hydrophilic gel. Drug Dev. Ind. Pharm. 30, 163-169.17. Yaw-Bin Huang, Jui-Sheng Chang, Pao-Chu Wu, Yi-Hung Tsai*, 2004. Determination of Xanthonolol by High-performance Liquid Chromat

15、ography for Pharmacokinetic Studies in Rats. J. Food Drug Anal. 12 ( 2) 97-101. 18. Yaw-Bin Huang, Yi-Hung Tsai, Wan-Chiech Yang, Jui-Sheng Chang, Pao-Chu Wu, 2004. Influence of formulation variables and manufacturing process on propranolol extended release profile from HPMC matrices tablets. 2004,

16、J. Appl. Polym. Sci. 93, 1886-1890.19. Chih-Hui Yang, Pao-Chu Wu, Yaw-Bin Huang, Yi-Hung Tsai*. 2004. A new approach for determining the stability of recombinant human epidermal growth factor by thermal Fourier transform infrared (FTIR) microspectroscopy. J. Biomol. Struc. Dyn. 22, 101-109.20. Yaw-B

17、in Huang, Yi-Hung Tsai, Wan-Chiech Yang, Jui-Sheng Chang, Pao-Chu Wu, Kozo Takayama, 2004. Once-daily propranolol extended-release tablet dosage form: formulation design and in vitro/in vivo investigation. Eur. J. Pharm. Biopharm. 58 (3) 607-614.21. Yaw-Bin Huang, Yi-Hung Tsai, Wan-Chiech Yang, Jui-

18、Sheng Chang, Pao-Chu Wu,2004. Optimization of sustained-release propranolol dosage form using Factorial design and Response surface methodology. Biol. Pharm. Bull. 27(10): 1626-1629.22. Pao-Chu Wu, Yaw-Bin Huang, I Chain Lin, Yi-Hung Tsai* , 2004. A Rapid, Simple High-Performance Liquid Chromatograp

19、hy Method for Determination of Traditional Chinese Medicine Preparation Shiunko. J. Food Drug Anal. 12(4): 311-315.23. Pao-Chu Wu, Yaw-Bin Huang, Chih-Kai Chang, Yeh-Long Chen, Cherng-Chyi Tzeng, Yi-Hung Tsai*, 2005. Pharmacokinetics of a new antitumor agent, 1-3-(furo3,2-cquinolin- 4-ylamino)phenyl

20、-ethanoe o-methyl-oxime, in rat using a high-performance liquid chromatography method. J. Food Drug Anal. 13: 78-82. 24. Yaw-Bin Huang, Yi-Hung Tsai, Shu-Hui Lee, Jui-Sheng Chang, Pao-Chu Wu*, 2005. Optimization of pH-independent release of nicardipine hydrochloride extended-release matrix tablets u

21、sing response surface methodology. Int. J. Pharm. 289:87-95.25. Chih-Hui Yang, Yaw-Bin Huang, Pao-Chu Wu, Yi-Hung Tsai*, 2005. The evaluation of stability of recombinant human epidermal growth factor in burn-injured pigs. Process Biochem 40:1661-1665. 26. Yaw-Bin Huang, Pao-Chu Wu, Ming-Wei Hsu, Yeh-Long Chen, Cherng-Chyi Tzeng, Yi-Hung Tsai*, 2005. Highly sensitive analysis of the anti-tumor agent 1-4-(furo 2,3-b-quinolin-4-ylamino)phen