1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemERiboflavin TetrabutyrateCat. No.: HY-B2239CAS No.: 752-56-7分式: CHNO分量: 656.72作靶點(diǎn): Reactive Oxygen Species作通路: Immunology/Inflammation; Metabolic Enzyme/Protease; NF-B儲(chǔ)存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C

2、 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 100 mg/mL (152.27 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲(chǔ)備液1 mM 1.5227 mL 7.6136 mL 15.2272 mL5 mM 0.3045 mL 1.5227 mL 3.0454 mL10 mM 0.1523 mL 0.7614 mL 1.5227 mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存式和期限。BIOLOGICAL ACTIVITY物

3、活性 Riboflavin Tetrabutyrate具有抗氧化和脂質(zhì)過氧化物去除活性的親脂性 素衍物。體外研究Riboflavin Tetrabutyrate inhibits oxygen uptake by lipid peroxidation. Riboflavin Tetrabutyrate is suppressiveagainst both NADPH-coupled and ascorbate-induced microsomal lipid peroxidation. Riboflavin Tetrabutyrateseems to exhibit its antioxida

4、tive action at or after the hydrogen atom is abstracted as a free radical from anactive methylene group of polyunsaturated fatty acids during the process of enzymic oxidation-reduction1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemEreaction 1.體內(nèi)研究 Riboflavin Tetrabutyrate might improve the metaboli

5、sm of lipids in patients suffering from atherosclerosis,diabetes, fatty liver and so on through the inhibition of lipid peroxide, resulting in the decrease of the elevatedserum lipid 1. Feeding of Riboflavin Tetrabutyrate results in an increase in the hepatic activity of 3-ketoacyl-CoA thiolase by 5

6、0% of the control level, while the activities of renal 3-ketoacyl-CoA thiolase and of hepaticand renal acyl-CoA synthetase and acyl-CoA dehydrogenase remain unaffected. The increase in hepatic 3-ketoacyl-CoA thiolase activity suggests that prolonged Riboflavin Tetrabutyrate administration results in

7、 anincreased beta-oxidation of fatty acid in the liver 2.PROTOCOLAnimal Rats: Riboflavin tetrabutyrate-14C (700 g, corresponding to 400 g of riboflavin; total radioactivity 2.19105Administration 3 cpm) is suspended in 0.2mL of soybean oil and given per os . In the case of injection, same amount ofRi

8、boflavin tetrabutyrate-14C is dissolved in 1mL of soybean oil and injected subcutaneously into the back ofrat 3.MCE has not independently confirmed the accuracy of these methods. They are for reference only.REFERENCES1. Tahara K, et al. Effect of riboflavin and riboflavin 2,3,4,5-tetrabutyrate on ra

9、t liver microsomallipid peroxidation. J Nutr Sci Vitaminol(Tokyo). 1974;20(2):81-8.2. Okuno E, et al. Effect of chronic administration of riboflavin 2,3,4,5-tetrabutyrate on the hepatic enzymes of fatty acid oxidation in therat. J Nutr Sci Vitaminol (Tokyo). 1983 Dec;29(6):637-42.3. Yagi K, et al. Studies on fatty acid esters of flavins. VI. Incorporation of riboflavin part of riboflavin tetrabutyrate-2-14C into flavinnucleotides in the organs of rat. J Vitaminol (Kyoto). 1969 Jun 10;15(2):155-9.McePdfHeightCaution: Product has not been fully validated