1、地區(qū)差別Forman D, et al. Lancet 1994;343:243-244Correa P, et al. Cancer Res. 1990;50:47374740.Fukase K,et al. Lancet 2008; 372: 39297幽門螺桿菌感染對(duì)胃黏膜上皮細(xì)胞增殖的影響Ma JL, et al. J Natl Cancer Inst 2012;104:1539 (12118)months35 (12109) monthsTakenaka R, et al. Aliment Pharmacol Ther 2011; 25:805812Lee YC. Gut 2013;

2、62:676682胃癌高發(fā)區(qū)(媽祖島)人群干預(yù)根除治療Matsuo T, et al. Helicobacter 2011;16: 415419Ernst PB, et al. Gastroenterology 2006;130:188206幽門螺桿菌感染率與胃癌發(fā)病率背離的“非洲之謎”Bhandari A. Curr Gastroenterol Rep. 2012;14:489-96Correa P, et al. Lancet 1975;2:5860. Correa P, et al. Cancer Res. 1990;50:47374740.100%50% 40% 8% Ernst PB

3、, et al. Gastroenterology 2006;130:188206 1%Bhandari A. Curr Gastroenterol Rep. 2012;14:489-96根除幽門螺桿菌逆轉(zhuǎn)胃黏膜變化實(shí)施中存在困難!日本根除幽門螺桿菌預(yù)防胃癌的新策略J Gastroenterol 2014: 49:18Nardone G, et al. Dig Dis 2007;25:214217JAMA. 2013;309(6):578-586Helicobacter. 2007;12(5):575-578Proc Jpn Acad Ser B Phys Biol Sci. 2011;87:

4、405-14Jpn J Clin Oncol. 2012;42:987-94血清胃蛋白酶原和幽門螺桿菌抗體聯(lián)合檢測(cè)預(yù)測(cè)胃癌發(fā)生風(fēng)險(xiǎn)“正?！蔽阜俏s性胃炎輕、中度萎縮性胃炎重度萎縮性胃炎,廣泛腸化ABCD胃癌高危人群篩查：ABC法Proc Jpn Acad Ser B Phys Biol Sci. 2011;87:405-14Jpn J Clin Oncol. 2012;42:987-94Seminars in Cancer Biology 23P (2013) 492-501高效的根除方案中必須包含高效的質(zhì)子泵抑制劑 在推薦的所有根除幽門螺桿菌方案中均含有質(zhì)子泵抑制劑（PPI）20mg bid20mg bidMcNicholl AG, et al. Aliment Pharmacol Ther 2012; 36: 414-425Lee VW, et al. J Clin Pharm Ther. 2010;35:343-50.(WHO