1、Age-related diseases and cancer Age-related diseases COENZYME IP-1CONTENTSA. NAD biosynthetic pathways and metabolismB. NAD consuming enzymes in health and diseaseC. Age-related diseases and cancerD. Mechanisms of NAD Precursors in humans and animal modelsE. NAD and the hallmarks of agingP-2A.NAD bi

2、osynthetic pathways and metabolismP-3NAD biosynthetic pathways and metabolismEric Verdin. (2015). Special Section 350（6265）: 1208-1213.P-4NAD biosynthetic pathways and metabolism in different cellular compartments.B.NAD consuming enzymes in health and diseaseP-5NAD consuming enzymes in health and di

3、seaseE F. Fang,. (2017). NAD+: a key metabolic regulator with great therapeutic potential: 1120-1143.P-6NAD availability can influence the activity of three groups of master regulator enzymesthe sirtuins, the PARPs and cyclic ADP-ribose synthases. Each group of enzymes regulate many biological proce

4、sses and can thus couple changes in NAD levels with a wide range of physiological responses.C.Age-related diseases and cancerP-71980s1930sP-8Age-related diseases and cancer could be the consequence of a decline in NAD+ concentrationsAmanda Garrido (2017). Trend in cancer 181: 181-199.Age-related dis

5、eases and cancer Metabolic syndrome including cardiovascular disorders, type 2 diabetes and obesity, Neurodegenerative diseases such as Alzheimer and Parkinsondiseases, arthritis, and osteoporosis, and cancer are some of the diseases that commonly affect human health during aging.D.Benefits and mech

6、anisms of NAD precursors in humans and animal modelsP-9Benefits and mechanisms of NAD precursors in humans and animal modelsGSultani. (2017). Trends in Molecular Medicine23（10）: 900-918P-10Benefits and mechanisms of NAD precursors in humans and animal modelsGSultani. (2017). Trends in Molecular Medi

7、cine23（10）: 900-918P-11Benefits and mechanisms of NAD precursors inhumans and animal modelsGSultani. (2017). Trends in Molecular Medicine23（10）: 900-918P-12E.NAD and the hallmarks of agingP-13NAD and the hallmarks of agingGSultani. (2017). Trends in Molecular Medicine23（10）: 900-918P-14NAD and the hallmarks of agingGSultani. (2017). Trends in Molecular Medicine23（10）: 900-918P-15NAD and the hallmarks of agingGSultani. (2017). Trends in Molecular Medicine23（10