Hotline:400-820-3792Inhibitors?Agonists?ScreeningLibrarieswww.MedChemENSC-60339Cat.No.:HY-119172CASNo.:70-09-7分?式:C??H??ClN?O?分?量:486.95作?靶點(diǎn):Bacterial作?通路:Anti-infection儲(chǔ)存?式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性數(shù)據(jù)體外實(shí)驗(yàn)DMSO:5mg/mL(10.27mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制備儲(chǔ)備液1mM2.0536mL10.2680mL20.5360mL5mM0.4107mL2.0536mL4.1072mL10mM0.2054mL1.0268mL2.0536mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存?式和期限。BIOLOGICALACTIVITY?物活性NSC-60339外排泵的抑制劑和AcrAB-TolC的底物，聚對(duì)苯?甲酸衍?物，?種潛在的癌癥化療化合物。體外研究NSC60339hasbeencorrelatedwiththesensitivity,resistance,orcross-resistanceof7tumorlinestophthalanilidetreatmentinvivo.Thesensitivetumors(L1210,L1210/MTX,L1210/ara-C,andP815)rapidlytakesupthedrugandretaineditprimarilyaslipid-bounddrugforthe24-hrexperimentalperiod.Theresistanttumor,L1210/NSC60339,and2cross-resistanttumors,P388/VCRandP815/VLB,tookupasmuchdrugas1/2MasterofSmallMolecules—您?邊的抑制劑?師www.MedChemEthesensitivetumorsdidby0.5hr,buttherewasaneffluxoflipid-bounddrugfromtheseresistanttumorsby24hr[3].REFERENCES[1].D.W.Yesair,etal.RelationshipofPhthalanilide-LipidComplexestoUptakeandRetentionof2-Chloro-4′,4″-di(2-imidazolin-2-yl)terephthalanilide(NSC60339)bySensitiveandResistantP388LeukemiaCells.CANCERRESEARCH26Part1:202-207,February1966.[2].YesairDW,etal.Theretentionoreffluxofphthalanilide(NSC60339)-lipidcomplexesbysensitiveorresistantmurinetumorcellsandEscherichiacoliB.CancerRes.1968Feb;28(2):314-9.[3].HaynesKM,etal.IdentificationandStructure-ActivityRelationshipsofNovelCompoundsthatPotentiatetheActivitiesofAntibioticsinEscherichiacoli.JMedChem.2017Jul27;60(14):6205-6219.[4].AbdaliN,etal.RevivingAntibiotics:EffluxPumpInhibitorsThatInteractwithAcrA,aMembraneFusionProteinoftheAcrAB-TolCMultidrugEffluxPump.ACSInfectDis.2017Jan13;3(1):89-98.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly