Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEMethylenebluehydrateCat.No.:HY-D0958CASNo.:122965-43-9Synonyms:BasicBlue9hydrate;CI-52015hydrate;Methylthioniniumchloridehydrate分?式:C??H??N?S.Cl.xH?O作?靶點(diǎn):GuanylateCyclase;MonoamineOxidase;NOSynthase;Microtubule/Tubulin作?通路:GPCR/GProtein;NeuronalSignaling;Immunology/Inflammation;CellCycle/DNADamage;Cytoskeleton儲(chǔ)存?式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY?物活性Methyleneblue(BasicBlue9)hydrate?種鳥(niǎo)苷酸環(huán)化酶(sGC)，單胺氧化酶A(MAO-A)和NO合酶(NOS)抑制劑。Methylenebluehydrate?種?管加壓劑，在醫(yī)療中通常?作染料。Methylenebluehydrate通過(guò)?氧化氮合成酶/鳥(niǎo)苷酸環(huán)化酶信號(hào)通路降低脈沖前抑制。Methylenebluehydrate?種氧化還原循環(huán)化合物，能夠穿過(guò)?腦屏障。MethylenebluehydrateTau聚集抑制劑。亞甲藍(lán)可減輕腦?腫，減弱?膠質(zhì)細(xì)胞活化，減少神經(jīng)炎癥。體外研究Methyleneblue(BasicBlue9)hydrate(4.5μM;BV2microglia)alterstheimmuneprofileofLPS-activatedBV2microgliaanddecreasedthelevelofCD14,IL-1β,TNF-α,andCCL2mRNA[3].體內(nèi)研究Methyleneblue(BasicBlue9)hydrate(50and100mg/kg;i.p.;once,for25min;maleNMRImice)reducesabsentprepulseinhibition[1].Methylenebluehydrate(20and40mg/kg;p.o.;daily,for6months;CaMKIIα-tTAtransactivatormice)preservescognitioninmiceexpressingfull-lengthpro-aggreganthumanTau[2].Methylenebluehydrate(2mg/kg;i.v.;once,for1d;TBI-treatedmaleBALB/cmice)reducesTBI-inducededemaandneuroinflammationandreducesacutedepression-likebehavior[3].Methylenebluehydrate(2mg/kg;i.v.;once,for1d;TBI-treatedmaleBALB/cmice)reducesthepercentageofinflammatoryfactor[3].AnimalModel:MaleNMRImice[1]1/3MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemEDosage:50and100mg/kgAdministration:Intraperitonealinjection;once,for25minutesResult:Reducedtheprepulseinhibitionandreducedtheincreaseinlocomotoractivitycausedbyphencyclidine(PCP).AnimalModel:CaMKIIα-tTAtransactivatormice[2]Dosage:20and40mg/kgAdministration:Oraladministration;daily,for6monthsResult:InhibitedTauaggregationinCaMKIIα-tTAtransactivatormice.AnimalModel:TBI-treatedmaleBALB/cmice[3]Dosage:2mg/kgAdministration:Intravenousinjection;once,for1dayResult:DecreasedthelevelofCD14,IL-1β,TNF-α,andCCL2mRNA.AnimalModel:TBI-treatedmaleBALB/cmice[3]Dosage:2mg/kgAdministration:Intravenousinjection;once,for1dayResult:Reducedthepercentageofmyeloid(CD11b+/GR1+)cells,reducedIL-1βandenhancedIL-10expressioninmicroglia.戶使?本產(chǎn)品發(fā)表的科研?獻(xiàn)?Theranostics.2021Oct17;11(20):9884-9903.?RedoxBiol.2020Sep;36:101601.?BiomedResInt.2021May15.?ExpTherMed.2019Nov;18(5):4049-4057.?EvidBasedComplementAlternatMed.2020Mar10;2020:3524641.Seemorecustomervalidationsonwww.MedChemEREFERENCES2/3MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemE[1].KlamerD,et,al.Phencyclidine-inducedbehaviourinmicepreventedbymethyleneblue.BasicClinPharmacolToxicol.2004Feb;94(2):65-72.[2].Hochgr?feK,et,al.Preventivemethylenebluetreatmentpreservescognitioninmiceexpressingfull-lengthpro-aggreganthumanTau.ActaNeuropatholCommun.2015May10;3:25.[3].FennAM,et,al.Methyleneblueattenuatestraumaticbraininjury-associatedneuroinflammationandacutedepressive-likebehaviorinmice.JNeurotrauma.2015Jan15;32(2):127-38.McePdfHeightCaution:Producthasnotbeen