PharmaceuticalanalysisIdentificationofmicrosublimationofborneolinBezoarAntidotalTabletIdentificationofmicrosublimation

ofborneolinBezoarAntidotalTabletAuthor:(RanQiwen)Attentions1. Thisproductcannotbecompatiblewithalga,euphorbiapekinensis,euphorbiakansuianddaphnegenkwa.2. ThisproductcannotbecompatiblewithFangfengTongshengwan.3. Thisproductcannotbecombinedwithchloralhydrate,morphine,phenobarbitalandothermedicines,soastoavoidtheacutepoisoningsymptomsoflethargy,respiratorycenterdepressionandhypotensionofpatient.4. Thisproductcannotbecombinedwithtetracyclines,phosphates,sulfates,nitrates,nitrites,ferrousiron,isoniazid,etc.,soastopreventthetoxicityofrealgarfromincreasingduetothegenerationoftracenitricacidandsulfuricacidinthestomach.Ifrequiredtotaketheabovemedicinesaccordingtotreatmentneeds,thepatientmusttakethematanintervaltimeof2-3h.5. Thisproductcannotbecombinedwithcardiacglycosides,centraldepressant,sulfonamides,aminoglycosides,macrolideantibiotics,quinindium,vitaminB1andB6,enzymicpreparations,aspirins,antacids,thiazidediuretics,hypoglycemicmedicinesandotherChineseherbapreparationscontainingarsenite.6. Thisproductcannotbecombinedwithmedicinescontainingalkaloidandmetalions.7. Thisproductcannotbecombinedwithcalcicmilkanddairyproducts.AttentionsFunctionsandindicationsClearingheatandremovingtoxicitySuitableforseriousendogenousheatSwellingandpaininthroatSwellingandpainingingivaDentalulcerSwellingandpainineyesExplanationonprescriptionofBezoarAntidotalTabletAdversereactionPatientssufferingfromdeficiencyofspleenandstomach,thinsloppystool,andallergicconstitutionandkidsmayhaveadversereactionswhentakingthismedicineseveraltimesorinlargedosageContents1.Identificationbasis2.Identificationprinciple3.Instrumentandreagent4.Identificationcontent5.Identificationsteps6.IdentificationconclusionKeyanddifficultpointsMasterSublimationidentificationtechnologyFamiliarSublimationidentificationdeviceUnderstandMethodtoinnovateandexploresublimationidentificationCorrectlyjudgethemethodconfirmedbychemicalidentificationofborneol.Undertheprincipleofchemicalidentification1.IdentificationbasisThepharmaceuticalstandardofBezoarAntidotalTabletiscollectedinthetextofChinesePharmacopoeia(2020).[Pharmaceuticalingredients]calculusbovisfactitius,realgar,gypsum,rhubarb,radixscutellariae,platycodongrandiflorum,borneolandlicorice.[Identification](2)Take1tabletofthisproductandgrindittofinepowder.Conductmicrosublimationtoittoobtainthewhitesublimate.Next,add1-2dropsofnewlyprepared1%vanillinsulfuricacidsolution.Finally,theedgeofdropletturnsrosered.1.IdentificationbasisBorneolRhubarbLicoriceRhubarbRadixscutellariaeRadixscutellariaeLicoriceLicoricePlatycodongrandiflorumPlatycodongrandiflorumflowerBorneol1.Identificationbasis1)TaskAccordingtotheprovisionsinChinesePharmacopoeia,completetheidentificationofborneolinBezoarAntidotalTabletasastudentandatesterinthesimulatedworkingscenarioandprocess.Learnandmasterthemicrosublimationidentificationtechnology,understandtheidentificationprincipleandcompletelyandcorrectlywritetestrecordsandinspectionreports.(1)PartI1.Identificationbasis1)WorkingbasisMicrosublimationmethod:Takeaweighingbottleandputitontheasbestosedwiregauze.Putthepowderofbezoarantidotaltabletintheweighingbottle(equivalentto1/3ofthevolumeofthebottle),covertheweighingbottlewithawatchglass,andheattheweighingbottlewithanalcohollampundertheasbestosedwiregauzeuntilthepowderisburnt.Next,removethelampforcoolingandoverturnthewatchglassontheweighingbottle,withwhitesublimatebeingcondensated.Then,takethesublimateandadd1-2dropsofnewlyprepared1%vanillinsulfuricacidsolution.Finally,theedgeofdropletturnsrosered.(1)PartI1.Identificationbasis3)Preparationsfortestidentification1.Alcohollamp(alcoholforlampandmatchstick)2.Tripodal,asbestosedwiregauze,weighingbottleandwatchglass.3.Takeaweighingbottleandputitontheasbestosedwiregauzeoftripodal.Then,placeappropriateamountofsamplepowderandcoverthebottlewithwatchglass,andheatthebottlewithanalcohollampundertheasbestosedwiregauzeuntilthepowderisburnt.Next,removethelampforcoolingandgetthesublimateontheglassslide.Overturntheglassslideandobservethecrystalformandcolorofsublimatewithmicroscope(unshapedcolorlessflakycrystals).Takethesublimateandadd1-2dropsofnewlyprepared1%vanillinsulfuricacidsolution.Finally,theedgeofdropletturnsrosered.(1)PartI1.Identificationbasis(2)PartII-Microsublimationidentificationofborneol1)Reagentpreparation1%sulfuricacidvanillintestsolution:weighandanalyze0.1gpurifiedvanillinandadd10mlsulfuricacidfordissolution.Then,shakeitwellandcontainitwithadroppingbottleandstickthelabel.2)PreparationofinstrumentWashingandarrangementofweighingbottle,watchglassandmortar.Arrangementofalcohollamp.PreparationofBezoarAntidotalTablet(1)PartI1.Identificationbasis(2)PartII-Microsublimationidentificationofborneol3)IdentificationCrushsample.Extractborneolsublimate.Identifyborneolcrystal(condensation).(1)Propertyidentification(2)ColoridentificationJudgeresult.Writetestreportaccordingtoidentificationrecords.(1)PartIReferencemethodsformicrosublimationidentificationofborneol1.Identificationbasis1)Summarizetheprincipleofmicrosublimationidentification.2)Summarizethecharacteristicsofmicrosublimationidentification.3)Summarizetheoperationstepsofmicrosublimationidentification.(2)PartII-conclusionTreatmentofweighingbottleWashthemortarandweighingbottleanddrythemforlateruse.GrindtabletintopowderEnsurenoparticlesinthepowderHeatthepowderforsublimationHeatthepowderslowlyatapropertemperature.ControlthetemperaturebyadjustingthespacingbetweenalcohollampflameandasbestosedwiregauzeRemovethelampforcoolingTakedownthewatchglassuntilitcoolscompletely.Addsomewateronthewatchglasstolowerthetemperatureandfacilitatethecondensationofsublimate1.Identificationbasis4)Thecolorreactionmechanismofvanillin-sulfuricacidmaybetheborneol,afterdehydrogenationandoxidationinconcentratedsulfuricacid,(borneolorterpenoid)maygeneratepurple-redsubstanceafteraddedwithvanillin.5.Sublimationidentificationtechnologyalsoincludescruciblemethodandevaporatingdishmethod.However,thesetwomethodsarerarelyused.Forexample,theycanbeusedtoidentifytherealgarinXiaoerJingfengsan.(2)PartIII1.IdentificationbasisBorneolCarbocationRoseredcondensationChemicalidentificationExplanationonprinciple1.IdentificationbasisTestdate____________________Temperature__________Relativehumidity__________Nameoftestproduct__________Doseform____________Specification______________Manufacturer________________BatchNo.____________Validity__________________Testbasis__________________________________________Testpurpose______________[Identification]IdentificationofsublimateinterpenoidsStandardprovisionPhenomenon:Conclusions:StandardandregulationoncoloridentificationofterpenoidsPhenomenon:Conclusions:Testedby:Checkedby:Page:Report:microsublimationidentificationofborneolinBezoarAntidotalTablet1.IdentificationbasisEvaluationonmicrosublimationidentificationresultsofborneolinBezoarAntidotalTablet(percentagesystem)TestindicatorsContentandobservationpointScoreAssessmentlevelABCDE1.00.7