Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemE(S,R,S)-AHPC-Bocderivative1Cat.No.:HY-173097CASNo.:2086298-33-9Synonyms:VH032-Bocderivative1分?式:C??H??N?O?S分?量:560.71作?靶點(diǎn):MALT1作?通路:MetabolicEnzyme/Protease;NF-κB儲(chǔ)存?式:Powder-20°C3yearsInsolvent-80°C6months-20°C1month溶解性數(shù)據(jù)體外實(shí)驗(yàn)DMSO:50mg/mL(89.17mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制備儲(chǔ)備液1mM1.7835mL8.9173mL17.8345mL5mM0.3567mL1.7835mL3.5669mL10mM0.1783mL0.8917mL1.7835mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；?旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。儲(chǔ)備液的保存?式和期限：-80°C,6months;-20°C,1month。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)?內(nèi)使?，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)?內(nèi)使?。BIOLOGICALACTIVITY?物活性(S,R,S)-AHPC-Bocderivative1(Compound80-9;VH032-Bocderivative1)?種選擇性蛋?酶體降解物，靶向MALT1，招募E3泛素連接酶CRBN與MALT1形成三元復(fù)合物，導(dǎo)致MALT1泛素化并隨后蛋?酶體降解。(S,R,S)-AHPC-Bocderivative1通過(guò)破壞CBM復(fù)合體抑制NF-κB信號(hào)通路，顯?出在ABC-DLBCL細(xì)胞中誘導(dǎo)凋亡的潛?。(S,R,S)-AHPC-Bocderivative1有望?于MALT1依賴性癌癥的研究，如彌漫性?B細(xì)胞淋巴瘤(1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemEDLBCL)[1]。REFERENCES[1].QINH,etal.PROTEINDEGRADATIONCOMPOUNDTARGETINGMALT1.WO2023143249A1.2023-08-03.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792ax/p>