Hotline:400-820-3792Inhibitors ? ScreeningLibraries ? Proteinswww.MedChemEα-Amylase-IN-14Cat.No.:HY-178935CASNo.:1099611-82-1分子式:C??H?NO?分子量:243.21作用靶點:Amylases;ReactiveOxygenSpecies(ROS)作用通路:MetabolicEnzyme/Protease;Immunology/Inflammation;NF-κB儲存方式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY生物活性α-Amylase-IN-14是Nicotinic(HY-B0143)的衍生物，是一種α-淀粉酶(α-amylase)抑制劑，與α-淀粉酶蛋白具有良好的相互作用(-5.55kcal/mol)。α-Amylase-IN-14是一種具有雙重抗炎和降血糖作用的藥物。α-Amylase-IN-14對DPPH和ABTS自由基也表現(xiàn)出良好的清除效果。α-Amylase-IN-14可用于糖尿病的研究[1]。體外研究α-Amylase-IN-14(Compound2h)(20-100μM,30min)exhibitsahalf-maximalinhibitoryconcentrationIC50valueof12.88μMagainstDPPH[1].α-Amylase-IN-14(20-100μM)exhibitsahalf-maximalinhibitoryconcentrationIC50valueof16.35μMagainstABTS[1].α-Amylase-IN-14(2-10μg,10min)exhibitsahalf-maximalinhibitoryconcentrationIC50valueof1.516μgagainstα-Amylase[1].α-Amylase-IN-14(20-100μM,15min)showsanti-inflammatorywithIC50valueof21.69μMinhumanbloodsample[1].REFERENCESRamakrishnanK,etal.Discoveryofnewpyridine3-carboxylicacid-basedpharmacophoresasdualanti-inflammatoryandanti-hyperglycemicagents.SciRep.2025Oct3;15(1):34536.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792Fax:021-5