第1題WhichaspectsdoesNotchsignalingregulateoforganogenesis.?AneurogenesisBmyogenesisCvasculogenesisDhematopoiesis正確答案：ABCD第2題WhenwastheNotchmolecularanalysisandsequencingindependentlyundertaken?A1970B1980C1917D1973第3題Thenon-canonicalNotchsignalingisligand/CSL-independent第4題CanonicalNotchincludes？ANotchreceptorsBNotchligandsCtargetgenesDEGF-likerepeats正確答案：ABC第5題Howmanynotchreceptorsarethereincanonicalnotchsiganling?A1B2C4D5第6題Howmanynotchligandsarethereincanonicalnotchsiganling?A1B2C3D5第7題TheNotchreceptorisproducedintheendoplasmicreticulum(ER)第8題Notchtargetsgenesinclud?AhesBheyCNrarpDc-myc正確答案：ABCD第9題Inmostcasesthemediatorsofnon-canonicalNotchsignalingareunknown第10題Whatisthemostwellstudiedandconservedeffectofnon-canonicalNotchfunction？AregulationofWnt/β-cateninsignaling.BregulationofapoptosisCregulationofdifferentiationDregulationofproliferation第11題TheimportanceofNotchsignalinghasbeenassociatedwithbothnormalhematopoiesisandhematologicalmalignancies第1題Accordingtothecourseandcelldifferentiation,leukemiacanbedividedinto？AacuteleukemiaBchronicleukemiaCmyeloidleukemiaDlymphcyticleukemia正確答案：AB第2題accordingtothecelllineageinvolved,leukemiacanbedividedinto?AmyeloidleukemiaBlymphcyticleukemiaCacuteleukemiaDchronicleukemia正確答案：AB第3題Whatfactorsarerelatedtothepathogenesisofleukemia?APhysicalfactorsBChemicalfactorsCBiologicalfactorsDHereditaryfactors正確答案：ABCD第4題What'sthesymptomsofleukemia?AanemiaBbleedingCinfectionsDsplenomegaly正確答案：ABCD第5題FABmeas“French-American-British”.Establishedin1976,thissystemdefineseightsubtypesfromM0-M7第6題FABdefines3subtypesincludingAL1BL2CL3DL4正確答案：ABC第7題WHOsystemdifines3subtypesincludingPrecursorBcellALL(B-ALL)PrecursorTcellALL(T-ALL)andBurkittcellleukemiaAB-ALLBT-ALLCBurkittcellleukemiaDETP-ALL正確答案：ABC第8題Tomakeadiagnosisofleukemia,whatshallwetakeintoconsiderations?AcytopeniaBclinicalmanifestationsCthebonemarrowexaminationsDbloodexaminations正確答案：BCD第9題TheclinicalmanifestationsofleukemiaarecausedbyeitherFailureofnormalHematopoiesisandleukemiccellsinfiltrationAFailureofnormalHematopoiesisBinfectionCleukemiccellsinfiltrationDbleeding正確答案：AC第10題4.Bleedingisthepresentingfeatureinabout40%ofleukemiapatients第11題CentralnervoussystemisoftenattackedafterachievingCRinleukemia第12題Tomakeadiagnosisofleukemia,Whatexaminationsshallwedo?AmorphologyBimmunophenotypingCcytogeneticsDmolecularbiology正確答案：ABCDPart3Primaryimmunethrombocytopenia第1題WhichagegroupoftheITPpatientsismostlikelytohavebleedingsymptoms?APediatricITPBAdultyoungerthan40yCAgebetween40and60yDPatientsolderthan60y第2題WhichofthefollowingarethepathogenesisofITPALossofimmunetolerancetoplateletantigensBincreasedplateletdestructionCDecreasedplateletproduction正確答案：ABC第3題AllofITPpatientsneedtreatmentassoonaspossibleincaseofbleeding.第4題TheITPpatientshavelessmegakarycytesinbonemarrow.第5題PersistentITPdescribespatientswithITPlastingformorethan12months.第6題ITPpatientsfrequentlyhavefatiguesymptom.第7題Whatisthefirst-linetherapyofITP?ACorticosteroidBIVIGCTPO-RAsDRituximab正確答案：AB第8題IfITPstartedtakingpredisone,he/sheshouldkeepusingitforover3months.第9題Thesustainedresponserateofsplenectomyisover60%inITPpatients.第10題Rituximabisachimericantibodytargeting：ACD19BCD20CCD21DCD38第11題WhichofthefollowingbelongtoTPO-Ras?ARomiplostimBEltrombopagCrhTPODRituximab正確答案：ABC第12題EltrombopagandRomiplostimsharethesametargetonc-Mpl.第四章習(xí)題第1題Patientspreparingforabonemarrowtransplantneedabloodtransfusionduetoanemia,andthepreferredbloodproductisAWholebloodBErythrocytesuspensionCLeukocyte-poorRBCDWashedRBCEConcentratedredbloodcells第2題Whichofthefollowingstatementaboutthetreatmentofacuteleukemiabonemarrowtransplantationiswrong？AAllogeneicbonemarrowmatchedwithHLABShouldbecarriedoutafterthefirstchemotherapyremissionCItshouldbecarriedoutearly,regardlessofageandgenderDAutologousstemcelltransplantationisfeasibleEAllogeneicbonemarrowtransplantationmaycureacuteleukemia第3題AnemiathatcanbetreatedwithHSCTisAMegaloblasticanemiaBAplasticanemiaCAutoimmunehemolyticanemiaDChronicanemiaEIrondeficiencyanemia第4題ComparedwithautologousHSCT,therecurrenceratioofleukemiapatientsafterallogeneicHSCTisAHigherBLowerCSimilarDUncertainEAlloftheaboveisright第5題Whichofthefollowingstatementaboutlatecomplicationsafterhematopoieticstemcelltransplantationisright？ACataractBHypogonadismCHypothyroidismDSecondarymalignanciesEAlloftheaboveisright正確答案：E第6題AutologousHSCTdoesnotresultineitherofthefollowingconditions.AImmunosuppressionBTransplantfailureCRejectionDLeukoencephalopathyEHemorrhagiccystitis第7題TheappropriatetimeforallogeneicHSCTis,AAfterthefirstcompleteremissionofhigh-riskgroupsforALLandANLLBAfterthesecondCRoflow-riskgroupforALLCEarlystageofCML(within1year)DAcuteaplasticanemiashouldbetransplantedassoonaspossibleEAlloftheaboveisright正確答案：E第8題TheminimalamountofnucleatedstemcellsfortransplantationisA2×105/kgB2×106/kgC2×107/kgD2×108/kgE2×109/kg第9題Topreventgraftversushostdisease(GVHD)afterallogeneicHSCT,Whichofthefollowingdrugsiseffective?ACyclophosphamide(CTX)BCyclosporineA(CyA)CMethotrexate(MTX)DIntravenousinfusionofgammaglobulininlargedosesEAlloftheaboveisright正確答案：E第10題WhichofthefollowingstatementaboutdonorandrecipientinAllogeneicHSCTisright？ATransplantationoftwoidenticalindividualswithABO-compatibleBBasedontissuetypingof6-10HLAantigensCIthastobeaparentalorrelativetransplantDIthastobeasiblingtransplantEItisatransplantingbetweenpeopleofthesamesex第11題Whichdrugisusedtomobilizeperipheralbloodstemcells？AG-CSFBCyclophosphamideCCytarabineDDexamethasoneEAlloftheaboveisright正確答案：E第12題AftercordbloodHSCT,therecoverytimeofperipheralbloodneutrophilwasapproximatelyA2weeksB3weeksC4weeksD6weeksE8weeks第13題MobilizationagentofallogeneicHSCTisgenerallyselectedAG-CSFBCyclophosphamideCCytarabineDDexamethasoneEAlloftheaboveisright第14題WhichofthefollowingstatementsaboutGVHDiswrong?AAllogeneicHSCTwithHLAmatcheddonorshasalowincidenceofgraftrejectionBTherejectionrateofSAAishigherthanthatofleukemiaCRemovaloflymphocytesfromdonorhematopoieticstemcellsreducesgraftrejectionDTherejectionrateofSAAtransplantationwasindependentofmultipletransfusionsbeforetransplantationECordbloodHSCThasalowincidenceofrejection第15題WhichofthefollowingdonorsispreferredforallogeneicHSCT？AHLAidenticalDonorBBasicallythesameHLAasthedonorCOneortwoHLAsitesmatcheddonorDThreeHLAsitesmatcheddonorEFullydisparatedonor第五章習(xí)題第1題Whichgeneticabnormalityisrequiredtoascertainthediagnosisofburkittlymphoma?Ac-myc/IgHBbcl-2/IgHCc-myc/bcl-2Dc-myc/bcl-6第2題WhichcytogeneticanalysisarerequiredtoascertainthediagnosisofdiffuselargeBcelllymphoma(doublehitortriplehit)?AIgHBc-mycCbcl-2Dbcl-6正確答案：BCD第3題MYCtranslocationismostfrequentinwhichtypeoflymphoma?AdiffuselargeBcelllymphomaBfollicular

lymphomaCburkittlymphomaDMALT第4題WhicharepositivepredictivefactorsforgastriclymphomaremissionfollowingHPeradication?AabsenceofAP12MALTmutationBdistallocationinstomachCpresenceofAP12MALTmutationDneoplasiabeyondthesubmucosa正確答案：AB第5題WhichtypeofT-NHLhasthemostfavorableprognosis?AperipheralT-celllymphoma,nototherwisespecifiedBanaplasticlargecelllymphoma,ALK-Canaplasticlargecelllymphoma,ALK+Dnaturalkiller/T-celllymphoma第6題WhichmoleculeisnotincludedinHansalgorithm?ABcl-2BCD10CBcl-6DMUM-1第7題Whichtypeoflymphomaisindolent?AdiffuselargeBcelllymphomaBburkittlymphomaCmantlecelllymphomaDmarginalzonelymphoma第8題Whichcytogeneticabnormalityischaracteristicofmantlecelllymphoma?At(11,18)(q21;q21)Bt(14,18)(q21;q32)Ct(8,14)(q24;q32)Dt(11,14)(q13;q32)第9題WhichmoleculeisnotincludedinRMHimmunemarkerscoringsystemforCLL?ACD23BCD103CCD5DCD22第10題Which

gene

mutation

canbeusedtodifferentiatehairycellleukaemiafromotherBcellchroniclymphoproliferativedisease?ABRAFV600EBMYD88L256PCMAP2K1DCyclinD1第11題WhichdrugdramaticallychangedtheoutcomeofCML?AImatinibBRetinoidacidCArsenictrioxideDdecitabine第12題WhichisthepreferredchoiceofCMLinthefollowingdrugs？Aα-interferonBdasatinibCAra-cDChidamide第13題WhichmightbeseeninlaboratorytestsofCMLAIncreasedPLTBDecreasedPLTCDecreasedWBCnumbersDDecreasedRBCnumbers正確答案：ABD第14題WhatbiomarkersmightbepositiveinCML?APh+Bbcr-abl+CPML-RARaDt(15;17)正確答案：AB第15題WhichsymptomscanbeseeninCMLpatients？AFatigueBfeverCHugespleenDecchymosis正確答案：ABCD第16題WhichisincorrectindescribingCLL?ALymphoidmalignancyBIncreasewithagingCuEnlargedlymphnodesDoftenseeninyoungpatient第17題WhichbiomarkerssuggestpoorprognosisinCLL?A13q-B17p-Cbcr-abl+D11q-正確答案：BD第18題Whichdrugisthepreferredchoiceforrelapse/refractoryCLL?AIbrutinibBthrombopoietinCglucocorticoid

Drituximab

第19題WhichsymptomscanpresentinCLLpatients？Aenlargement

of

lymph

nodesBanemiaChemorrhageDsplenomegaly

正確答案：ABCD第20題Inthefollowingtherapies,whichcanbeappliedintreatingCLLAglucocorticoid

Bradiotherapy

Ctransplantation

Drituximab

正確答案：ABCD第六章習(xí)題第1題Whichofthefollowingfactorsmayworkonmechanismsoftumorescape?AA.antigenicmodulationBB.immuneinhibitorssecretedbytumorcellsCC.activationofmacrophagesDD.lackofco-stimulatorymoleculesonthetumorcells正確答案：ABD第2題

Anexampleofaknownoncogenicvirusis:AA

Herpeszoster.BB

HIV-2.CC

Epstein-Barrvirus.DD

Vesicularstomatitisvirus.第3題Boonandcolleaguesshowedthatsyngeneictransplantabletumorswhichmutatesuchthattheyexpressstrongtransplantationantigensarerejected.Theycalledthesevariants:AA

Non-immunogenicantigensBB

XenogeneicantigensCC

tumorantigensnegativeantigensDD

MCA.第4題Stronglyimmunogenictumorsappear:AA

Invirtuallyallcancers.BB

Onlyinlymphomaandleukemia.CC

Inimmunosuppressedpatients.DD

Inphysicallyorchemicallyinducedtumors第5題InBurkitt'slymphoma,avaccineagainstwhichofthefollowingmightproveuseful:AA

Epstein-Barrvirus.BB

Marek'sdiseasevirus.CC

Human

papillomavirus.DD

HTLV-1第6題

Adiagnosticmarkerfortumorsofthecolonis:AA

Alpha-fetoprotein.BB

Carcinoembryonicantigen(CEA).CC

ThepresenceofReed-Sternbergcells.:DD

EBV-relatedantigens.第7題Antigensnormallyexpressedonlyonembryoniccellsbutalsosometimesfoundontumorsareknownas:AA

Oncofetalantigens.BB

HTLV-1.CC

Maternal.DD

Neonatal.第8題Thenormalimmunologicalcontroloftumorsisreferredtoas:AA

Immunologicaltolerance.BB

Immunesurveillance.CC

TypeIIIhypersensitivity.DD

Immunologicalsilence.第9題Whichofthefollowingfactorsmayworkonmechanismsoftumorescape?AA.antigenicmodulationBB.immuneinhibitorssecretedbytumorcellsCC.activationofmacrophagesDD.lackofco-stimulatorymoleculesonthetumorcellsEE.absenceofMHCclassIImolecule正確答案：ABD第10題Abouttumorantigen,whichofthefollowingstatementsarecorrect?AA.AFPisatumor-specificantigensBBCEAisatumor-specificantigensCCAFPisaTAADDCEAisaTAAEEBothAFPandCEAareTSA正確答案：CD第11題Whichofthefollowingwaysofantibodyworkinimmunesurveillancearefalse?AACDCBBADCCCCOpsonizationofantibodytoantigensDDmediatingtypeⅠhypersensitivityEEmediatingtypeⅠVhypersensitivity正確答案：DE第七章習(xí)題第1題Whatmethodscanbeusedtodiagonseleukemiainclinicalparctice?AMorphologyBImmunologyCCytogeneticsDMolecularbiology正確答案：ABCD第2題WhataretheadvantagesofNGS(Nextgenerationofsequencing)?AhighsensitivityBlowexpenseChighthroughouDmutationabundance正確答案：ACD第3題WhatisthecharacteristicfusiongeneofCML?APML-RARαBBCR/ABLCFLT3-ITDDJAK2-V617F第4題WhatisthecharacteristicfusiongeneofAPL?APML-RARαBBCR/ABLCFLT3-ITDDJAK2-V617F第5題WhatisthecharacteristicgenechangeofMPN?APML-RARαBBCR/ABLCFLT3-ITDDJAK2-V617F第6題BCR/ABListhecharacteristicfusiongeneofCML,andthisfusiongenescanaffactkeukemiacells.WhichofthefollowingarecausedbyBCR/ABL?AEnhancecellapoptosisBInducecellproliferationCInhibitcellapoptosisDChangeadhesionpathway正確答案：BCD第7題WhichtypesarebelongingtoBCR/ABLfusiongene?AP190BP210CP230DP250正確答案：ABC第8題WhatisthechromosomaltranslocationofBCR/ABL?At(9;22)(q34;q11)Bt(15;17)(q22;q21)Ct(8;21)(q22;q22)Dt(9;11)(q22;q23)第9題WhatisthechromosomaltranslocationofPML-RARα?At(9;22)(q34;q11)Bt(15;17)(q22;q21)Ct(8;21)(q22;q22)Dt(9;11)(q22;q23)第10題Whichisthemostfrequentlyusedreferencegeneforleukemiageneexamination?AABLBGUSCBCRDGAPDH第11題WhichcanbeusedinthediagnosisandMRDmonitoringofM3？APML-RARαBBCR/ABLCFLT3-ITDDJAK2-V617F第12題WhichcanbeusedinthediagnosisandMRDmonitoringofCML？APML-RARαBBCR/ABLCFLT3-ITDDJAK2-V617F第13題FewerM3patientshaveotherRARαfusionpartnergenes.WhichofthefollowingoptionsarerareRARαfusiongenesinM3patients?APLZF-RARαBNPM-RARαCNuMA-RARαDSTAT5b-RARα正確答案：ABCD第14題FewerM3patientshaveotherRARαfusionpartnergenes.WhichofthefollowingoptionsarerarechromosomaltranslocationinM3patients?At(11;17)(q23;q21)Bt(5;17)(q35;q21)Ct(11;17)(q13;q21)Ddup(17)(q21.3;q23)正確答案：ABCD第15題FewerM3patientshaveotherRARαfusionpartnergenes.WhichofthefollowingoptionsarenotsensitivetoATRAtreatment?APLZF-RARαBNPM-RARαCNuMA-RARαDSTAT5b-RARα正確答案：AD第八章習(xí)題第1題Wheredoesbloodformationoccurindevelopingembryos?ASpleenBLiverCBonemarrowDyolksac第2題Wheredoesbloodformationoccurinchildren?AfemurBtibiaCBonemarrowDyolksac正確答案：ABC第3題Wheredoesbloodformationoccurinadult?ApelvisBcranium,CvertebraeDsternum正確答案：ABCD第4題Whatdoesbloodcellsinclude?AwhitebloodcellsBredbloodcellsCplateletsDplasma正確答案：ABC第5題Whatactonthebonemarrow,an