1、,無機(jī)化學(xué),有機(jī)化學(xué),金屬有機(jī),碳（氫)金屬鍵的形成和反應(yīng),A. Yamamoto: 有趣和有用 多樣性與意外性,A. Yamamoto (1967):,Ziegler-Natta catalyst: Transition metal complex + Main group metal compound TiCl4 + AlEt3 in Ar Co(acac)3 + AlR3 + PPh3 CoH(N2)(PPh3)3,N2,MS of the gas from thermolysis: N2, H2, no O2. Excluded from the possibility of air

2、leakage.,Peal Harbor complex !,A. Yamamoto: Organotransition Metal Chemistry p. 140.,The Nobel Prize in Chemistry 2001 for their work on chirally catalysed hydrogenation reactions William S. Knowles Ryoji Noyori St. Louis, MO, USA Nagoya University, Chikusa, Nagoya, Japan 1938 for his work on chiral

3、ly catalysed oxidation reactions K. Barry Sharpless 1941 The Scripps Research Institute La Jolla, CA, USA,1917 -,www.nobel.se,基于金屬有機(jī)化學(xué)的化學(xué)工藝 (1) 鈀催化的從乙烯出發(fā)合成乙醛(Wacker process) (2) Ziegler-Natta催化劑催化烯烴聚合; (3) Rh催化的烯烴氫化； (4) 美國(guó)孟山都公司Rh催化從MeOH和CO出發(fā)制備醋酸的工藝 (5) 聯(lián)合碳化公司的Rh催化的氫甲酰化生產(chǎn)醛的工藝; (6) 孟山都公司從合成氣出發(fā)合成乙二醇的生

4、產(chǎn)流程； (7) DuPont公司的尼龍-66前體合成工藝； (8) BASF、Rohm (9) 日本高沙香料公司的薄荷醇的不對(duì)稱合成 (10) 金屬催化的不對(duì)稱合成技術(shù)在藥物合成工業(yè)的實(shí)際應(yīng)用,W. Schlenk 2 Li + R2Hg,1951年發(fā)現(xiàn)二茂鐵: 合成(P. L. Pauson, T. J. Kealy of Duquesene University) Nature 1951, 168, 1039.,1952: S. A. Miller et al. at British Oxygen Co. (already has this compound for three year

5、) J. Chem. Soc. 1952, 632. 1952: R. B. Woodward, G. Wilkinson (Harvard Univ) E. O. Fischer (Univ. Munich) ferrocene structure based on physical measurement fell short of proof Shortly after: X-ray (Penn. State College and Oxford Univ.),C & EN News 2001, Dec. 3, P. 37,烯烴金屬鍵理論 Dewar (1951)：Bull. Soc. Chim. France Chatt, Duncanson (1953): J. Chem. Soc. 用于說明Zeises salt 的結(jié)構(gòu) 影響Hoechst-Wacker process,Wacker Process,Monsanto Acetic Acid Process,Hydrof