1、微信公眾號：醫(yī)學(xué)博士英語南京醫(yī)科大學(xué)小白老師大閱讀第 13 天 小白老師醫(yī)學(xué)考博英語網(wǎng)絡(luò)課程 AsthmaCertain bacteria protect against a disease that is a growing threatCAN you be too clean? That is the question posed by the hygiene hypothesis, which seeks to explain why, as many illnesses have become rarer in rich countries, some have become more

2、 common. The hygiene hypothesis posits that the rise of several of these diseases, including asthma, eczema and type-1 diabetes (all of which seem associated with malfunctions of the immune system), has been caused by improvements in hygiene of the sort that have helped get rid of other illnesses. E

3、xactly how that might happen is unclear. But at the AAAS meeting Brett Finlay of the University of British Columbia, in Vancouver, persuasively filled in some of the blanks in the case of asthma.Asthma is caused by chronic inflammation of the airways, and inflammation is an immune response. The thin

4、king behind the hygiene hypothesis is that a lack of exposure to parasites and pathogens in what has become an unnaturally clean environment means a childs immune system does not develop appropriately. Evidence that asthma is a consequence of overcleanliness includes the facts that farm-raised child

5、ren are less prone to it than city-raised ones (farms are full of bacteria and other critters that provoke immune responses), that those born by Caesarean section are more prone than others (they do not receive an initial bacterial inoculation from maternal faeces and vaginal fluids), and that those

6、 treated with antibiotics as babies are also more prone. Dr Finlay therefore wondered if he could find bacteria which might be involved in asthma protection in the guts of children.To this end he got in touch with the organisers of the Canadian Healthy Infant Longitudinal Development (CHILD) study,

7、which looks at the development of children from birth to the age of five. He asked if the studys organisers could include theregular collection of faeces as part of their protocol and he thus obtained stool samples taken at the ages of three months, 12 months and annually thereafter, the bacterial c

8、ontents of which he analysed.Asthma does not normally manifest itself before a child is five, but a tendency to wheeze and a reaction to a particular skin-prick test are good indicators that the child in question will eventually become asthmatic. Recording both of these are routine parts of CHILD. D

9、r Finlay was therefore able to correlate the composition of an infants gut flora with the presence or absence of these indicators. When he did so he found that children deficient, at the age of three months, in four relatively rare bacteria, Faecalibacterium, Lachnospira, Rothia and Veillonella, wer

10、e 20 times more likely than those playing host to these species to manifest the two predictive indicators.Armed with these results he joined forces with Philip Cooper, a researcher at St Georges Hospital in London, to try the same thing in Ecuador. This is a country which has a similar prevalence (2

11、0%) of asthma to that in Canada. The researchers found that in Ecuador, too, infantile gut bacteria predict susceptibility to asthmaexcept that in this case a completely different set of bugs are responsible.How the presence in three-month-olds of particular microorganisms protects against asthma re

12、mains unknown. But the fact that two different sets of them can do so provides a way to investigate further. It is all a question of finding out what the various bugs have in common.These discoveries, moreover, offer the possibility of treatment. If a newborn is found to be deficient in the relevant

13、 bacteria, an inoculation of them into that childs gut, perhaps in the form of an oral probiotic, might put matters right. Testing this idea would, naturally, require clinical trials, but it is a promising line of inquiry. Meanwhile, Dr Finlays advice to parents of young children is that, though cle

14、anliness may be next to godliness, it is possible to go too far.This article appeared in the Science and technology section of the print editionunder the headline “Four good bugs”1. prone 英 prn美 pronadj.易于的； 俯臥的； 有傾向的； 傾斜的，坡陡的 2. protocol 英 prtkl美 protkln.禮儀；（外交條約的）草案；（數(shù)據(jù)傳遞的）協(xié)議；科學(xué)實驗報告（或計劃） vt.把寫入議定書，在議定書中擬定（或頒布）； vi.擬定議定書，